메뉴 건너뛰기




Volumn 28, Issue 11, 1998, Pages 3506-3513

Re-expression of RAG-1 and RAG-2 genes and evidence for secondary rearrangements in human germinal center B lymphocytes

Author keywords

B lymphocyte; Germinal center; RAG 1; RAG 2; Somatic hypermutation

Indexed keywords

IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LYMPHOCYTE MEMBRANE IMMUNOGLOBULIN;

EID: 0031768520     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199811)28:11<3506::AID-IMMU3506>3.0.CO;2-J     Document Type: Article
Times cited : (46)

References (37)
  • 2
    • 0028198052 scopus 로고
    • Regulation of gene expression at early stages of B-cell differentiation
    • Hagman, J. and Grosschedl, R., Regulation of gene expression at early stages of B-cell differentiation. Curr. Opin. Immunol. 1994. 6: 222-230.
    • (1994) Curr. Opin. Immunol. , vol.6 , pp. 222-230
    • Hagman, J.1    Grosschedl, R.2
  • 3
    • 0028256203 scopus 로고
    • Two waves of recombinase gene expression in developing thymocytes
    • Wilson, A., Held, W. and MacDonald, H. R., Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 1994. 179: 1355-1360.
    • (1994) J. Exp. Med. , vol.179 , pp. 1355-1360
    • Wilson, A.1    Held, W.2    MacDonald, H.R.3
  • 4
    • 0025301095 scopus 로고
    • RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination
    • Oettinger, M. A., Schatz, D. G., Gorka, C. and Baltimore, D., RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990. 248: 1517-1523.
    • (1990) Science , vol.248 , pp. 1517-1523
    • Oettinger, M.A.1    Schatz, D.G.2    Gorka, C.3    Baltimore, D.4
  • 5
    • 0028828269 scopus 로고
    • Down-regulation of RAG-1 and RAG-2 gene expression in preB cells after functional immunglobulin heavy chain rearrangement
    • Grawunder, U., Leu, T. M., Schatz, D. G., Werner, A., Rolink, A. G., Melchers, F. and Winkler, T. H., Down-regulation of RAG-1 and RAG-2 gene expression in preB cells after functional immunglobulin heavy chain rearrangement. Immunity 1995. 3: 601-608.
    • (1995) Immunity , vol.3 , pp. 601-608
    • Grawunder, U.1    Leu, T.M.2    Schatz, D.G.3    Werner, A.4    Rolink, A.G.5    Melchers, F.6    Winkler, T.H.7
  • 6
    • 0030006070 scopus 로고    scopus 로고
    • Clonal selection and learning in the antibody system
    • Rajewsky, K., Clonal selection and learning in the antibody system. Nature 1996. 381: 751-758.
    • (1996) Nature , vol.381 , pp. 751-758
    • Rajewsky, K.1
  • 8
    • 0027499537 scopus 로고
    • Receptor editing: An approach by autoreactive B cells to escape tolerance
    • Gay, D., Saunders, T., Camper, S. and Weigert, M., Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 1993. 177: 999-1008.
    • (1993) J. Exp. Med. , vol.177 , pp. 999-1008
    • Gay, D.1    Saunders, T.2    Camper, S.3    Weigert, M.4
  • 9
    • 0027478391 scopus 로고
    • Receptor editing in self-reactive bone marrow B cells
    • Tiegs, S. L., Russel, D. M. and Nemazee, D., Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 1993. 177: 1009-1019.
    • (1993) J. Exp. Med. , vol.177 , pp. 1009-1019
    • Tiegs, S.L.1    Russel, D.M.2    Nemazee, D.3
  • 10
    • 0027532192 scopus 로고
    • B lymphocytes may escape tolerance by revising their antigen receptors
    • Radic, M. Z., Erikson, J., Litwin, S. L. and Weigert, M., B lymphocytes may escape tolerance by revising their antigen receptors. J. Exp. Med. 1993. 177: 1165-1173.
    • (1993) J. Exp. Med. , vol.177 , pp. 1165-1173
    • Radic, M.Z.1    Erikson, J.2    Litwin, S.L.3    Weigert, M.4
  • 11
    • 0026060620 scopus 로고
    • Intraclonal generation of antibody mutants in germinal centers
    • Jacob, J., Kelsoe, G., Rajewsky, K. and Weiss, U., Intraclonal generation of antibody mutants in germinal centers. Nature 1991. 354: 389-392.
    • (1991) Nature , vol.354 , pp. 389-392
    • Jacob, J.1    Kelsoe, G.2    Rajewsky, K.3    Weiss, U.4
  • 12
    • 0026331458 scopus 로고
    • Maturation of the immune response in germinal centers
    • Berek, C., Berger, A. and Apel, M., Maturation of the immune response in germinal centers. Cell 1991. 67: 1121-1129.
    • (1991) Cell , vol.67 , pp. 1121-1129
    • Berek, C.1    Berger, A.2    Apel, M.3
  • 14
    • 0026586045 scopus 로고
    • The molecular and cellular basis of affinity maturation in the antibody response
    • Nossal, G. J., The molecular and cellular basis of affinity maturation in the antibody response. Cell 1992. 68: 1-2.
    • (1992) Cell , vol.68 , pp. 1-2
    • Nossal, G.J.1
  • 15
    • 0030460833 scopus 로고    scopus 로고
    • Neoteny in lymphocytes. Rag1 and Rag2 expression in germinal center B cells
    • Han, S., Zheng, B., Schatz, D. G., Spanopoulou, E. and Kelsoe, G., Neoteny in lymphocytes. Rag1 and Rag2 expression in germinal center B cells. Science 1996. 274: 2094-2097.
    • (1996) Science , vol.274 , pp. 2094-2097
    • Han, S.1    Zheng, B.2    Schatz, D.G.3    Spanopoulou, E.4    Kelsoe, G.5
  • 16
    • 0030475466 scopus 로고    scopus 로고
    • Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells
    • Hikida, M., Mori, M., Takai, T., Tomochika, K., Hamatani, K. and Ohmori, H., Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 1996. 274: 2092-2094.
    • (1996) Science , vol.274 , pp. 2092-2094
    • Hikida, M.1    Mori, M.2    Takai, T.3    Tomochika, K.4    Hamatani, K.5    Ohmori, H.6
  • 17
    • 0030764978 scopus 로고    scopus 로고
    • V(D)J recombinase activity in a subset of germinal center B lymphocytes
    • Han, S., Zheng, B., Shimoda, M., Schlissel, M. S. and Kelsoe, G., V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 1997. 278: 301-305.
    • (1997) Science , vol.278 , pp. 301-305
    • Han, S.1    Zheng, B.2    Shimoda, M.3    Schlissel, M.S.4    Kelsoe, G.5
  • 20
    • 0004886564 scopus 로고
    • The influence of somatic mutation on the immune response
    • Weigert, M., The influence of somatic mutation on the immune response. Prog. Immunol. 1986. 6: 139-143.
    • (1986) Prog. Immunol. , vol.6 , pp. 139-143
    • Weigert, M.1
  • 21
    • 0025955528 scopus 로고
    • Mutation and selction during the secondary response to 2-phenyloxazolone
    • Rada, C., Gupta, S. K., Cherardi, E. and Milstein, C., Mutation and selction during the secondary response to 2-phenyloxazolone. Proc. Natl. Acad. Sci. USA 1991. 88: 5508-5512.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5508-5512
    • Rada, C.1    Gupta, S.K.2    Cherardi, E.3    Milstein, C.4
  • 22
    • 0027165531 scopus 로고
    • Up-regulated recombination-activating gene expression in slg-variant of a human mature B cell line undergoing secondary lg lambda rearrangements in cell culture
    • Stiernholm, N. B. and Berinstein, N. L., Up-regulated recombination-activating gene expression in slg-variant of a human mature B cell line undergoing secondary lg lambda rearrangements in cell culture. Eur. J. Immunol. 1993. 23: 1501-1507.
    • (1993) Eur. J. Immunol. , vol.23 , pp. 1501-1507
    • Stiernholm, N.B.1    Berinstein, N.L.2
  • 23
    • 0028986325 scopus 로고
    • + dual receptor B cells are present in the human peripheral repertoire
    • + dual receptor B cells are present in the human peripheral repertoire. J. Exp. Med. 1995. 181: 1245-1250.
    • (1995) J. Exp. Med. , vol.181 , pp. 1245-1250
    • Giachino, C.1    Radovan, E.2    Lanzavecchia, A.3
  • 24
    • 0023818720 scopus 로고
    • The human V(greek small letter script kappa) locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes
    • Straubinger, B., Huber, E., Lorenz, W., Osterholzer, E., Pargent, W., Pech, M., Pohlenz, H. D., Zimmer, J. and Zachau, H. G., The human V(greek small letter script kappa) locus. Characterization of a duplicated region encoding 28 different immunoglobulin genes. J. Mol. Biol. 1988. 199: 23-34.
    • (1988) J. Mol. Biol. , vol.199 , pp. 23-34
    • Straubinger, B.1    Huber, E.2    Lorenz, W.3    Osterholzer, E.4    Pargent, W.5    Pech, M.6    Pohlenz, H.D.7    Zimmer, J.8    Zachau, H.G.9
  • 25
    • 0022432374 scopus 로고
    • Subgroup IV of human immunoglobulin (greek small letter script kappa) light chains is encoded by a single germline gene
    • Klobeck, H. G., Bornkamm, G. W., Combriato, G., Mocikat, R., Pohlenz, H. D. and Zachau, H. G., Subgroup IV of human immunoglobulin (greek small letter script kappa) light chains is encoded by a single germline gene. Nucleic Acid Res. 1988. 13: 6515-6529.
    • (1988) Nucleic Acid Res. , vol.13 , pp. 6515-6529
    • Klobeck, H.G.1    Bornkamm, G.W.2    Combriato, G.3    Mocikat, R.4    Pohlenz, H.D.5    Zachau, H.G.6
  • 26
    • 0025730554 scopus 로고
    • V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism
    • Combriato, G. and Klobeck, H. G., V lambda and J lambda-C lambda gene segments of the human immunoglobulin lambda light chain locus are separated by 14 kb and rearrange by a deletion mechanism. Eur. J. Immunol. 1991. 21: 1513-1522.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 1513-1522
    • Combriato, G.1    Klobeck, H.G.2
  • 28
    • 0020503988 scopus 로고
    • Clusters of point mutations are found exclusively around rearranged antibody variable genes
    • Gearhart, P. J. and Bogenhagen, D. F., Clusters of point mutations are found exclusively around rearranged antibody variable genes. Proc. Natl. Acad. Sci. USA 1983. 80: 3439-3443.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3439-3443
    • Gearhart, P.J.1    Bogenhagen, D.F.2
  • 29
    • 0020569881 scopus 로고
    • Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene
    • Gorski, J., Rollini, P. and Mach, B., Somatic mutations of immunoglobulin variable genes are restricted to the rearranged V gene. Science 1983. 220: 1179-1181.
    • (1983) Science , vol.220 , pp. 1179-1181
    • Gorski, J.1    Rollini, P.2    Mach, B.3
  • 30
    • 0019794854 scopus 로고
    • Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation
    • Pech, M., Hoechtl, J., Schnell, H. and Zachau, H. G., Differences between germ-line and rearranged immunoglobulin V kappa coding sequences suggest a localized mutation. Nature 1981. 291: 668-670.
    • (1981) Nature , vol.291 , pp. 668-670
    • Pech, M.1    Hoechtl, J.2    Schnell, H.3    Zachau, H.G.4
  • 32
    • 0023161406 scopus 로고
    • Mutation drift and repertoire shift in the maturation of the immune response
    • Berek, C. and Milstein, C., Mutation drift and repertoire shift in the maturation of the immune response. Immunol. Rev. 1987. 96: 23-41.
    • (1987) Immunol. Rev. , vol.96 , pp. 23-41
    • Berek, C.1    Milstein, C.2
  • 33
    • 0026647158 scopus 로고
    • Natural occurrence and origin of somatically mutated memory B cells in mice
    • Schittek, B. and Rajewsky, K., Natural occurrence and origin of somatically mutated memory B cells in mice. J. Exp. Med. 1992. 176: 427-438.
    • (1992) J. Exp. Med. , vol.176 , pp. 427-438
    • Schittek, B.1    Rajewsky, K.2
  • 36
    • 0025119206 scopus 로고
    • Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: The role of somatic mutation and heavy/light chain pairing in the maturation of an immune response
    • Alzari, P. M., Spinelli, S., Mariuzza, R. A., Boulot, G., Poljak, R. J., Jarvis, J. M. and Milstein, C., Three-dimensional structure determination of an anti-2-phenyloxazolone antibody: the role of somatic mutation and heavy/light chain pairing in the maturation of an immune response. EMBO J. 1990. 9: 3807-3814.
    • (1990) EMBO J. , vol.9 , pp. 3807-3814
    • Alzari, P.M.1    Spinelli, S.2    Mariuzza, R.A.3    Boulot, G.4    Poljak, R.J.5    Jarvis, J.M.6    Milstein, C.7
  • 37
    • 0021202986 scopus 로고
    • Frequency of expressed immunoglobulin light chain genes in lipopolysaccharide-stimulated BALB/c spleen cells
    • Zhou, D., Lefkovits, I. and Kohler, G., Frequency of expressed immunoglobulin light chain genes in lipopolysaccharide-stimulated BALB/c spleen cells. J. Exp. Med. 1984. 160: 971-986.
    • (1984) J. Exp. Med. , vol.160 , pp. 971-986
    • Zhou, D.1    Lefkovits, I.2    Kohler, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.