HBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1)

European Journal of Immunology

Volumn 28, Issue 9, 1998, Pages 2839-2853

  Verkoczy, Laurent K ^a   Marsden, Philip A ^b   Berinstein, Neil L ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b ST MICHAEL'S HOSPITAL   (Canada)

^c DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

Author keywords

B cell development; Chromosomal localization; Differential display reverse transcription PCR; RAG1; Type II transmembrane protein

Indexed keywords

COMPLEMENTARY DNA; DNA; GLYCOPROTEIN; MEMBRANE PROTEIN; MESSENGER RNA;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; B LYMPHOCYTE; CARBOXY TERMINAL SEQUENCE; CHROMOSOME 10Q; DNA RECOMBINATION; DNA TRANSFECTION; GENE; GENE EXPRESSION REGULATION; GENE MAPPING; HUMAN; HUMAN CELL; MOLECULAR WEIGHT; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ADULT; AMINO ACID SEQUENCE; B-LYMPHOCYTES; BASE SEQUENCE; CELL LINEAGE; CLONING, MOLECULAR; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, RAG-1; HOMEODOMAIN PROTEINS; HUMANS; MEMBRANE GLYCOPROTEINS; MOLECULAR SEQUENCE DATA;

EID: 0031717164     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199809)28:09<2839::AID-IMMU2839>3.0.CO;2-6     Document Type: Article

References (59)

1. Schatz, D., Oettinger, M. and Baltimore, D., The V(D)J recombination activating gene (RAG-1). Cell 1989. 59: 1035-1048.
2. Oettinger, M., Schatz, D., Gorka, C. and Baltimore, D., RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science 1990. 248: 1517-1523.
3. Gellert, M., Molecular analysis of V(D)J recombination. Annu. Rev. Genet. 1992. 22: 425-446.
4. Mombaerts, P., Iacomini, J., Johnson, R., Herrup, K., Tonegawa, S. and Papaioannou, V., RAG-1-deficient mice have no mature B and T lymphocytes. Cell 1992. 68: 869-877.
5. Shinkai, Y., Rathbun, G., Lam, K., Oltz, E., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A. and Alt, F., RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 1992. 68: 855-867.
6. van Gent, D. C., McBlane, J. F., Ramsden, D. A., Sadofsky, M. J., Hesse, J. E. and Gellert, M., Initiation of V(D)J recombination in a cell-free system. Cell 1995. 81: 925-934.
7. McBlane, J. F., van Gent, D. C., Ramsden, D. A., Romeo, C., Cuomo, C. A., Gellert, M. and Oettinger, M. A., Cleavage at a V(D)J recombination signal requires only RAG-1 and RAG-2 proteins and occurs in two steps. Cell 1995. 83: 387-395.
8. Ramsden, D. A., Paull, T. T. and Gellert, M., Cell-free V(D)J recombination. Nature 1997. 388: 488-491.
9. Alt, F., Oltz, E., Young, F., Gorman, J., Taccioli, G. and Chen, J., VDJ recombination. Immunol. Today 1992. 13: 306-314.
10. Alt, F. W., Rathbun, G., Oltz, E., Taccioli, G. and Shinkai, Y., Function and control of recombination-activating gene activity. Ann. NY Acad. Sci. 1992. 652: 277-294.
11. Wilson, A., Held, W. and MacDonald, H. R., Two waves of recombinase gene expression in developing thymocytes. J. Exp. Med. 1994. 179: 1355-1360.
12. Grawunder, U., Leu, T. M., Schatz, D. G., Werner, A., Rolink, A. G., Melchers, F., and Winkler, T. H., Down-regulation of RAG1 and RAG2 gene expression in preB cells after functional immunoglobulin heavy chain rearrangement. Immunity 1995. 3: 5601-5610.
13. Ma, A., Fischer, P., Dildrop, R., Oltz, E., Rathburn, G., Achacoso, P., Stall, A. and W., A. F., Surface IgM mediated regulation of RAG gene expression in Eμ-N-myc B cell lines. EMBO J. 1992. 11: 2727-2734.
14. Stiernholm, B. J. N. and Berinstein, N. L., Upregulated RAG expression in slg-variants of a human mature B cell line undergoing secondary Igλ. rearrangements in cell culture. Eur. J. Immunol. 1993. 23: 1501-1507.
15. Verkoczy, L. K., Stiernholm, N. B. J. and Berinstein, N. L., Up-regulation of recombination activating gene expression by signal transduction through the slg receptor. J. Immunol. 1995. 154: 5136-5173.
16. Han, S., Zheng, B., Schatz, D. G., Spanopoulou, E. and Kelsoe, G., Neoteny in lymphocytes: RAG-1 and RAG-2 expression in germinal centre B cells. Science 1996. 274: 2094-2097.
17. Hikida, M., Mori, M., Takai, T., Tomochika, K., Hamatani, K. and Ohmori, H., Reexpression of RAG-1 and RAG-2 genes in activated mature mouse B cells. Science 1996. 274: 2092-2094.
18. Han, S., Dillon, S. R., Zheng, B., Shimoda, M., Schlissel, M. S. and Kelsoe, G., V(D)J recombinase activity in a subset of germinal center B lymphocytes. Science 1997. 278: 301-305.
19. Borgulya, P., Kishi, H., Uematsu, Y. and von Boehmer, H., Exclusion and inclusion of α and β T cell receptor alleles. Cell 1992. 69: 529-537.
20. Brandle, D., Muller, C., Rulicke, T., Hengartner, H. and Pircher, H., Engagement of the T-cell receptor during positive selection in the thymus down-regulates RAG-1 expression. Proc. Natl. Acad. Sci. USA 1992. 89: 9529-9533.
21. Desiderio, S. V., Yancoupoulos, G. D., Paskind, M., Thomas, E., Boss, M. A., Landau, N., Alt, F. W. and Baltimore, D., Insertion of N regions into heavy chain genes is correlated with expression of terminal deoxytransferase in B cells. Nature 1984. 311: 752-755.
22. Smider, V., Rathmell, W. K., Liber, M. R. and Chu, G., Restoration of x-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Science 1994. 266: 258-261.
23. Taccioli, G. E., Gottlieb, T. M., Blunt, T., Priestley, A., Demengeot, J., Mizuta, R., Lehmann, A. R., Alt, F. W., Jackson, S. P. and Jeggo, P. A., Ku 80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination. Science 1994. 265: 1442-1445.
24. Kirchgessner, C. U., Patil, C. K., Evans, J. W., Cuomo, C. A., Fried, L. M., Carter, T., Oettinger, M. A. and Brown, J. M., DNA-dependent kinase (p350) as a candictate gene for the murine scid defect. Science 1995. 267: 1178-1183.
25. Lees-Miller, S. P., Godbout, R., Chan, D. G., Weinfeld, M., Day III, R. S., Barron, G. M. and Allalunis-Turner, J., Absence of p350 subunit of a DNA-activated protein kinase from a radiosensitive human cell line. Science 1995: 1183-1185.
26. Li, Z., Otevrel, T., Gao, Y., Cheng, H.-L., Seed, B., Stamato, T. D., Taccioli, G. E. and Alt, F. W., The XRCC4 gene encodes a novel protein involved in DNA Double-strand break repair and V(D)J recombination. Cell 1995. 83: 1079-1089.
27. Roth, D. B., Lindahl, T. and Gellert, M., How to make ends meet. Curr. Biol. 1995. 5: 496-499.
28. Altschul, S. F., Gish, W., Miller, W., Myers, E. and Lipmann, D. J., Basic local alignment search tool. J. Mol. Biol. 1990. 215: 403-410.
29. Kozak, M., Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 1986. 44: 283-291.
30. Kyte, J. and Doolittle, R. F., A simple method for displaying the hydropathic character of a protein. J. Mol. Biol. 1982. 157: 105-114.
31. Chou, P. Y. and Fasman, G. D., Conformational parameters for amino acids in helical, β-sheet and random coils calculated from proteins. Biochemistry 1974. 13: 211-245.
32. Williams, A. F. and Barclay, A. N., The immunoglobulin superfamily-domains for cell surface recognition. Ann. Rev. Immunol. 1988. 6: 381-405.
33. Drickamer, K., The CRD domain of type II membrane proteins. Curr. Opin. Struc. Biol. 1993. 3: 393-401.
34. Smith, C. A., Gruss, H.-J., Davis, T. et al., CD30 antigen, a marker for hodgkin's lymphoma, is a receptor whose ligand defines an emerging family of cytokines with homology to TNF. Cell 1993. 73: 1349-1360.
35. Reithmeier, R. A. F., Intrinsic membrane protein structure: principles and prediction. In Structure of Biological Membranes. Curr. Opin. Struc. Biol. 1995. 5: 491-500.
36. Smith, C. A., Davis, T., Anderson, D., Solam, L., Beckmann, M. P., Jerzy, R., Dower, S. K., Cosman, D. and Goodwin, R. J., A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 1990. 248: 1019-1023.
37. Wong, S., Freeman, J. D., Kelleher, C., Mager, D. and Takei, F., LY-49 multigene family: new members of a super-family of type II membrane proteins with lectin-like domains. J. Immunol. 1991. 147: 1417-1423.
38. Wu, Q., Lahti, J. M., Air, G. M., Burrows, P. D. and Cooper, M. D., Molecular cloning of the murine BP-1/ 6C3 antigen: a member of the zinc-dependent mettalopeptidase family. Proc. Natl. Acad. Sci. USA 1990. 87: 993-997.
39. Orellana, A. and Hirschberg, C. B., Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line. J. Biol. Chem. 1994. 269: 2270-2276.
40. Bretscher, M. S. and Munro, S., Cholesterol and the Golgi apparatus. Science 1993. 261: 1280-1281.
41. Searle, A. G., Peters, J., Lyon, M. F., Hall, J. G., Evans, E. P., Edwards, J. H. and Buckle, V. J., Chromosome maps of man and mouse. IV. Ann. Hum. Genet. 1989. 53: 89-140.
42. Yang-Feng, T. L., Xue, F., Zhong, W., Cotecchia, S., Frielle, T., Caron, M. G., Lefkowitz, R. J. and Francke, U., Chromosomal organization of adregenergic receptor genes. Proc. Natl. Acad. Sci. USA 1990. 87: 1516-1520.
43. Cappellen, D., Frequent loss of heterozygosity on chromosome 10q in muscle-invasive transitional carcinomas of the bladder. Oncogene 1997. 14: 3059-3066.
44. Ittman, M., Allelic loss on chromosome 10 in prostate adenocarcinoma. Cancer Res. 1996. 56: 2143-2147.
45. Steck, P. A., Two tumor suppressive loci on chromosome 10 involved in human glioblastomas. Genes Chromosomes Cancer 1995. 12: 255-261.
46. Hikida, M., Mori, M., Kawabata, T., Takai, T. and Ohmori, H., Characterization of B cells expressing recombination activating genes in germinal centers of immunized mouse lymph nodes. J. Immunol. 1997. 158: 2509-2512.
47. Turka, L. A., Schatz, D. G., Oettinger, M. A., Chun, J. J. M., Gorka, C., Lee, K., McCormack, W. T. and Thompson, C. B., Thymocyte expression of RAG-1 and RAG-2: Termination by T cell receptor cross-linking. Science 1991. 253: 778-781.
48. Hertz, M. and Nemazee, D., BCR ligation induces receptor editing in IgM+IgD-bone marrow B cells in vitro. Immunity 1997. 6: 429-436.
49. Menetski, J. and Gellert, M., V(D)J recombination activity in lymphoid cell lines is increased by agents that elevate cAMR Proc. Natl. Acad. Sci. USA 1990. 87: 9324-9328.
50. Casillas, A. M., Thompson, A. D., Cheshier, S., Hernandez, S. and Aguilera, R. J., RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines. Mol. Immunol. 1995. 32: 167-175.
51. Zhuang, Y., Soriano, P. and Weintraub, H., The helix-loop-helix gene E2A is required for B cell formation. Cell 1994. 79: 875-884.
52. Tweedale, M. E., Lim, B., Jamal, N., Robinson, J., Zalcberg, J., Lockwood, G., Minden, M. and Messner, H. A., The presence of clonogeneic cells in high-grade lymphoma: a prognostic factor. Blood 1987. 69: 1307-1314.
53. Chomczynski, P. and Sacchi, N., Single-step method of RNA isolation by acid guanidium thiocyanate-phenolchloform extraction. Anal. Bioch 1987. 162: 156-159.
54. Liang, P. and Pardee, A. B., Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 1992. 257: 967-971.
55. Liang, P., Averboukh, L. and Pardee, A. B., Distribution and cloning of eukaryotic mRNAs by means of differential display: refinements and optimization. Nucl. Acids. Res. 1993. 21: 3269-3275.
56. Ioannou, P. A., Amemiya, C. T., Garnes, J., Kroisel, P. M., Hiroaki, S., Chen, C., Batzer, M. A. and de Jong, P. J., A new bacteriophage P1-derived vector for the propagation of large human DNA fragments. Nature Genet. 1994. 6: 84-89.
57. Lichter, P., Tang, C. J., Call, K., Hermanson, G., Evans, G. A., Housman, D. and Ward, D. C., High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. Science 1990. 247: 64-69.
58. Heng, H. and Tsui, L.-C., Modes of DAPI banding and simultaneous in situ hybridization. Chromosoma 1993. 102: 325-332.
59. Francke, U., Modes of DAPI banding and simultaneous in situ hybridization. Cytogenet. and Cell. Genet. 1994. 65: 206-219.