Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide

Journal of Biological Chemistry

Volumn 274, Issue 20, 1999, Pages 14163-14169

  Middleton, Steven A ^a   Barbone, Francis P ^a   Johnson, Dana L ^a   Thurmond, Robin L ^a   You, Yun ^b   McMahon, Frank J ^a   Jin, Renzhe ^a   Livnah, Oded ^d,e   Tullai, Jennifer ^a   Farrell, Francis X ^a   Goldsmith, Mark A ^c,d   Wilson, Ian A ^d   Jolliffe, Linda K ^a  

^a R W JOHNSON PHARMACEUTICAL RES I   (United States)

^b GLADSTONE INSTITUTE OF VIROLOGY AND IMMUNOLOGY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

^e HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; BINDING PROTEIN; ERYTHROPOIETIN; ERYTHROPOIETIN MIMETIC PEPTIDE; ERYTHROPOIETIN RECEPTOR; HORMONE ANALOG; METHIONINE; MUTANT PROTEIN; PHENYLALANINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIMERIZATION; ESCHERICHIA COLI; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STABILITY; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ERYTHROPOIETIN; ESCHERICHIA COLI; HUMANS; KINETICS; MODELS, MOLECULAR; MOLECULAR MIMICRY; MUTAGENESIS, SITE-DIRECTED; PEPTIDES, CYCLIC; PROTEIN BINDING; RECEPTORS, ERYTHROPOIETIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0033553469     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.20.14163     Document Type: Article

References (47)

1. Miyake, T., Kung, C. K.-H., and Goldwasser, E. (1977) J. Biol. Chem. 252, 5558-5564
2. Krantz, S. B. (1991) Blood 77, 419-434
3. Witthuhn, B. A., Quelle, F. W., Silvennoinen, O., Yi, T., Tang, B., Miura, O., and Ihle, J. N. (1993) Cell 74, 227-236
4. Quelle, F. W., Wang, D., Nosaka, T., Thierfelder, W. E., Stravopodis, D., Weinstein, Y., and Ihle, J. N. (1996) Mol. Cell. Biol. 16, 1622-1631
5. Klingmuller, U., Bergelson, S., Hsiao, J. G., and Lodish, H. F. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 8324-8328
6. Darnell, J. E. (1997) Science 277, 1630-1635
7. Broudy, V. C., Lin, N., Brice, M., Nakamoto, B., and Papyannopoulou, T. (1991) Blood 77, 2583-2590
8. Swada, K., Krantz, S. B., Sawyer, S. T., and Civin, C. T. (1988) J. Cell. Physiol. 137, 337-445
9. Hermine, O., Dong, Y. J., and Goldwasser, E. (1994) Blood 84, 811-814
10. Nagao, M., Matsumoto, S., Masuda, S., and Sasaki, R. (1993) Blood 81, 2503-2510
11. Dong, Y. J., and Goldwasser, E. (1993) Exp. Hematol. 21, 483-486
12. Philo, J. S., Aoki, K. H., Arakawa, T., Owers Narhi, L., and Wen, J. (1996) Biochemistry 35, 1681-1691
13. Jones, S. S., D'Andrea, A. D., Haines, L. L., and Wong, G. G. (1990) Blood 76, 31-35
14. Bazan, J. F. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 6934-6938
15. Bazan, J. F. (1990) Immunol. Today 11, 350-354
16. Johnson, D. L., Middleton, S. A., McMahon, F, Barbone, F. P., Kroon, D., Tsao, E., Lee, W.-H., Mulcahy, L. S., and Jolliffe, L. K. (1996) Protein Exp. Purif. 7, 104-113
17. Livnah, O., Stura, E. A., Johnson, D. L., Middleton, S. A., Mulcahy, L. S., Wrighton, N. C., Dower, W. J., Jolliffe, L. K., and Wilson, I. A. (1996) Science 273, 464-471
18. Livnah, O., Johnson, D. L., Stura, E. A., Farrell, F. X., Barbone, F. P., You, Y., Liu, K. D., Goldsmith, M. A., He, W., Krause, C. D., Pestka, S., Jolliffe, L. K., and Wilson, I. A. (1998) Nat. Struct. Biol. 5, 993-1003
19. Wrighton, N. C., Farrell, F., X., Chang, R., Kashyap, A., K., Barbone, F. P., Mulcahy, L. S., Johnson, D. L., Barrett, R. W., Jolliffe, L. K., and Dower, W. J. (1996) Science 273, 458-463
20. Syed, R. S., Reid, S. W., Li, C., Cheetham, J. C., Aoki, K. H., Liu, B., Zhan, H., Osslund, T. D., Chirino, A. J., Zhang, J., Finer-Moore, J., Elliott, S., Sitney, K., Katz, B. A., Matthews, D. J., Wendoloski, J. J., Egrie, J., and Stroud, R. M. (1998) Nature 395, 511-516
21. de Vos, A. M., Ultsch, M., and Kossiakoff, A. A. (1992) Science 255, 306-312
22. Somers, W., Ultsch, M., de Vos, A. M., and Kossiakoff, A. A. (1994) Nature 372, 478-481
23. Yamasaki, K., Naito, S., Anaguchi, H., Ohkubo, T., and Ota, Y. (1997) Nat. Struct. Biol. 4, 498-504
24. Bravo, J., Staunton, D., Heath, J. K., and Jones, E. Y. (1998) EMBO J. 17, 1665-1674
25. Muller, Y. A., Ultsch, M. H., and de Vos, A. M. (1996) J. Mol. Biol. 256, 144-159
26. Harlos, K., Martin, D. M. A., O'Brien, D. P., Jones, E. Y., Stuart, D. I., Polikarpov, I., Miller, A., Tuddenham, E. G. D., and Boys, C. W. G. (1994) Nature 370, 662-666
27. Walter, M. R., Windsor, W. T., Nagabhushan, T. L., Lundell, D. J., Lunn, C. A., Zauodny, P. J., and Narula, S. K. (1995) Nature 376, 230-235
28. Fan, Q. R., Mosyak, L., Winter, C. C., Wagtmann, N., Long, E. O., Wiley, D. C. (1997) Nature 389, 96-100
29. Middleton, S. A., Johnson, D. L., Jin R., McMahon, F. J., Collins, A., Tullai, J., Gruninger, R. H., Jolliffe, L. K., and Mulcahy, L. S. (1996) J. Biol. Chem. 271, 14045-14054
30. Johnson, D. L., Farrell, F. X., Barbone, F. P., McMahon, F. J., Tullai, J., Hoey, K., Livnah, O., Wrighton, N. C., Middleton, S. A., Loughney, D. A. Stura, E. A., Dower, W. J., Mulcahy, L. S., Wilson, I. A., and Jolliffe, L. K. (1998) Biochemistry 37, 3699-3710
31. Gaffen, S., Lai, S. Y., Xu, W., Gouillex, F., Groner, B., Goldsmith, M. A., and Greene, W. C. (1995) Proc. Natl Acad. Sci. U. S. A. 92, 7192-7196
32. Ward, W. H. J., Timms, D., and Fersht, A. R. (1990) Trends Pharmacol Sci. 11, 280-284
33. Wells, J. A. (1991) Methods Enzymol. 202, 390-411
34. Kitamura, T., Tange, T., Terasawa, T., Chiba, S., Kuwaki, T., Miyagawa, K., Piao, Y.-F., Miyazono, K., Urabe, A., and Takaku, F. (1989) J. Cell. Physiol. 140, 323-334
35. Woodcock, J. M., Bagley, C. J., Zacharakis, B., and Lopez, A. (1996) J. Biol. Chem. 271, 25999-26006
36. Rajotte, D., Cadieux, C., Haman, A., Wilkes, B. C., Clark, S. C., Hercus, T., Woodcock, J. A., Lopez, A., and Hoang, T. (1997) J. Exp. Med. 185, 1939-1950
37. Layton, J. E., Iaria, J, Smith, D. K., and Treutlein, H. R. (1997) J. Biol. Chem. 272, 29735-29741
38. Horsten, U., Müller-Newen, G., Gerhartz, C., Wollmer, A., Wijdenes, J., Heinrich, P. C., and Grötzinger, J. (1997) J. Biol. Chem. 272, 23748-23757
39. Yawata, H., Yasukawa, K., Natsuka, S., Murakami, M., Yamasaki, K., Hibi, M., Taga, T., and Kishimoto, T. (1993) EMBO J. 12, 1705-1712
40. Klein, B. K., Feng, Y., McWherter, C. A., Hood, W. F., Paik, K., and McKearn, J. P. (1997) J. Biol. Chem. 272, 22630-22641
41. Kalai, M., Montero-Julian, F. A., Grötzinger, J., Fontaine, V., Vandenbuasche, P., Deschuyteneer, R., Wollmer, A., Brailly, H., and Content, J. (1997) Blood 89, 1319-1333
42. Zdanov, A., Schalk-Hihi, C., and Wlodawer, A. (1996) Protein Sci. 5, 1955-1962
43. Barbone, F. P., Middleton, S. A., Johnson, D. L., McMahon, F. J., Tullai, J., Gruninger, R. H., Schilling, A. E., Jolliffe, L. K., and Mulcahy, L. S. (1997) J. Biol. Chem. 272, 4985-4992
44. Clackson, T., and Wells, J. A. (1995) Science 267, 383-386
45. Wells, J. A. (1995) Bio/Technology 13, 647-651
46. Wells, J. A., and de Vos, A. M. (1996) Annu. Rev. Biochem. 65, 609-634
47. Bass, S. H., Mulkerrin, M. G., and Wells, J. A. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 4498-4502