The mahogany mouse mutation: Further links between pigmentation, obesity and the immune system

Trends in Genetics

Volumn 15, Issue 11, 1999, Pages 429-431

  Jackson, Ian J ^a  

^a WESTERN GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERMEDIN; MELANOCORTIN RECEPTOR; PROOPIOMELANOCORTIN; PROTEIN DERIVATIVE;

ADRENAL INSUFFICIENCY; DRUG TARGETING; FEEDING BEHAVIOR; GENE EXPRESSION; GENETIC DISORDER; HAIR COLOR; HUMAN; HYPOTHALAMUS; MOUSE; MUTATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; SHORT SURVEY; SKIN PIGMENTATION;

ANIMALS; ENERGY METABOLISM; FEEDING BEHAVIOR; FRAMESHIFT MUTATION; GLYCOPROTEINS; HAIR COLOR; IMMUNOLOGIC DEFICIENCY SYNDROMES; INFLAMMATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANINS; MELANOCYTE-STIMULATING HORMONES; MELANOCYTES; MICE; MICE, MUTANT STRAINS; MOTOR ACTIVITY; OBESITY; PHENOTYPE; PIGMENTATION DISORDERS; PRO-OPIOMELANOCORTIN; PROTEINS; RECEPTORS, PITUITARY HORMONE;

SWIETENIA;

EID: 0033229992     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(99)01824-7     Document Type: Short Survey

References (21)

1. Krude, H. et al. (1998) Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat Genet. 19, 155-157
2. Robbins, L.S. eT al. (1993) Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter receptor function. Cell 72, 827-834
3. Valverde, P. et al. (1995) Variants of the melanocytestimulating hormone-receptor gene are associated with red hair and fair skin in humans. Nat Genet. 11, 328-330
4. Smith, R. et al. (1998) Melanocortin 1 receptor variants in an Irish population J. Invest. Dermatol. 111, 119-122
5. Huszar, D. et al. (1997) Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141
6. Vaisse, C. et al. (1998) Aframeshift mutation in human MC4R is associated with a dominant form of obesity. Hat. Genet. 20, 113-114
7. Yeo, G.S.H. et al. (1998) A frameshift mutation in MC4R associated with dominantly inherited obesity. Hat. Genet. 20, 111-112
8. Bultman, S.P. et al. (1992) Molecular characterisation of the mouse agouti locus. Ce//71,1-20
9. Ollmann, M.M. et al. (1998) Interaction of agouti protein with the melanocortin 1 receptor in vitro and in vivo. Genes Dev. 12, 316-330
10. Duhl, D.M. et al. (1994) Neomorphic agouti mutations in obese yellow mice. Hat Genet. 8, 59-65
11. Ollmann, M.M. et al. (1997) Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278, 135-138
12. Shutter, J.R. et al. (1997) Hypothalamic expression of ART, a novel gene related to agouti is up-regulated in obese and diabetic mutant mice. Genes Dev. 11, 593-602
13. Miller, K.A. et al. (1997) Genetic studies of the mouse mutations mahogany and mahoganoid. Genetics 146, 1407-1415
14. Dinulescu, D.M. et al. (1998) Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti. Proc. Natl. Acad. Sci. U. S. A. 95, 12707-12712
15. Nagle, D. L. et al. (1999) The mahogany protein is a receptor involved in suppression of obesity. Nature 398, 148-152
16. Gunn, T.M. et al. (1999) The mouse mahogany locus encodes a transmembrane form of human attractin. Nature 398, 152-156
17. Duke-Cohan, J.S. et al. (1998) Attractin (DPPT-L), a member of the CUB family of cell adhesion and guidance proteins, is secreted by activated human T lymphocytes and modulates immune cell interactions. Proc. Natl. Acad. Sci U. S. A. 95, 11336-11341
18. Duke-Cohan, J.S. et al. (1995) A novel form of dipeptidylpeptidase IV found in human serum. J. Biol. Chem. 270, 14107-14114
19. Proost, P. et al. (1999) Truncation of macrophage-derived chemokine by CD26/dipeptidyl-peptidase IV beyond its predicted cleavage site affects chemotactic activity and CC chemokine receptor 4 interaction. J. Biol. Chem. 274, 3988-3993
20. Catania, A. et al. (1996) The neuropeptide aMSH has specific recptors on neutrophils and reduces chemotaxis in vitro. Peptides 17, 675-679
21. Star, R.A. et al. (1995) Evidence of automne modulation of macrophage nitric-oxide synthase by alpha-melanocyte-stimulating hormone. Proc. Natl. Acad. Sci. U. S. A. 92, 8016-8020