Cell-cycle checkpoints that ensure coordination between nuclear and cytoplasmic events in Saccharomyces cerevisiae

Current Opinion in Genetics and Development

Volumn 10, Issue 1, 2000, Pages 47-53

  Lew, Daniel J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CYTOSKELETON PROTEIN; FUNGAL PROTEIN;

CELL CYCLE; CELL NUCLEUS; CYTOKINESIS; CYTOPLASM; CYTOSKELETON; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TARGETING; REVIEW; SACCHAROMYCES;

SACCHAROMYCES CEREVISIAE;

EID: 0034000976     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(99)00051-9     Document Type: Review

References (49)

1. Hartwell L.H., Weinert T.A. Checkpoints: controls that ensure the order of cell cycle events. Science. 246:1989;629-634.
2. Elledge S.J. Cell cycle checkpoints: preventing an identity crisis. Science. 274:1996;1664-1672.
3. Lillie S.H., Brown S.S. Immunofluorescence localization of the unconventional myosin, Myo2p, and the putative kinesin-related protein, Smy1p, to the same regions of polarized growth in Saccharomyces cerevisiae. J Cell Biol. 125:1994;825-842.
4. Chowdhury S., Smith K.W., Gustin M.C. Osmotic stress and the yeast cytoskeleton: phenotype-specific suppression of an actin mutation. J Cell Biol. 118:1992;561-571.
5. Delley P.A., Hall M.N. Cell wall stress depolarizes cell growth via hyperactivation of RHO1. J Cell Biol. 147:1999;163-174. This paper shows that actin depolarization in response to mild heat shock requires a signaling pathway involving the putative plasma membrane sensor Wsc1p, the Rho guanine nucleotide exchange factor Rom2p, and the protein kinase C homologue Pkc1p. These same proteins are suggested to be responsible for the subsequent repolarization of actin, in this case acting through the MAPK Mpk1p. Depolarization and subsequent repolarization of actin are shown to drive a similar relocalization on the part of glucan synthase, responsible for synthesizing a major cell wall polysaccharide, and it is suggested that this behavior constitutes a stress response that helps the cell to survive cell wall damage.
6. Lew D.J., Reed S.I. A cell cycle checkpoint monitors cell morphogenesis in budding yeast. J Cell Biol. 129:1995;739-749.
7. McMillan J.N., Sia R.A.L., Lew D.J. A morphogenesis checkpoint monitors the actin cytoskeleton in yeast. J Cell Biol. 142:1998;1487-1499.
8. 2 cyclins. EMBO J. 12:1993;3417-3426.
9. Sia R.A.L., Herald H.A., Lew D.J. Cdc28 tyrosine phosphorylation and the morphogenesis checkpoint in budding yeast. Mol Biol Cell. 7:1996;1657-1666.
10. Sia R.A.L., Bardes E.S.G., Lew D.J. Control of Swe1p degradation by the morphogenesis checkpoint. EMBO J. 17:1998;6678-6688.
11. Kaiser P., Sia R.A.L., Bardes E.S.G., Lew D.J., Reed S.I. Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1. Genes Dev. 12:1998;2587-2597.
12. Deshaies R.J. Phosphorylation and proteolysis: partners in the regulation of cell division in budding yeast. Curr Opin Genet Dev. 7:1997;7-16.
13. Ma X-J., Lu Q., Grunstein M. A search for proteins that interact genetically with histone H3 and H4 amino termini uncovers novel regulators of the Swe1 kinase in Saccharomyces cerevisiae. Genes Dev. 10:1996;1327-1340.
14. Tanaka S., Nojima H. Nik1: a Nim1-like protein kinase of S. cerevisiae interacts with the Cdc28 complex and regulates cell cycle progression. Genes Cells. 1:1996;905-921.
15. Coleman T.R., Tang Z., Dunphy W.G. Negative regulation of the Wee1 protein kinase by direct action of the nim1/cdr1 mitotic inducer. Cell. 72:1993;919-929.
16. Parker L.L., Walter S.A., Young P.G., Piwnica-Worms H. Phosphorylation and inactivation of the mitotic inhibitor Wee1 by the nim1/cdr1 kinase. Nature. 363:1993;736-738.
17. Tang Z., Coleman T.R., Dunphy W.G. Two distinct mechanisms for negative regulation of the Wee1 protein kinase. EMBO J. 12:1993;3427-3436.
18. Pollack B.P., Kotenko S.V., He W., Izotova L.S., Barnoski B.L., Pestka S. The human homologue of the yeast proteins skb1 and hsl7p interacts with jak kinases and contains protein methyltransferase activity. J Biol Chem. 274:1999;31531-31542. This paper provides data suggesting that JBP1, a human homologue of Hsl7p, is a protein arginine methyltransferase. JBP1 was identified as a JAK-interacting protein, and immunoprecipitated JBP1 methylates histones and myelin basic protein in vitro.
19. 2 arrest. The authors suggest that the morphogenesis checkpoint operates through bifurcated pathways promoting both Swe1p stabilization and inhibition of Mih1p.
20. Shulewitz M.J., Inouye C.J., Thorner J. Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol. 19:1999;7123-7137. This paper shows that Hsl7p is localized to the daughter side of the mother-bud neck in a manner that depends on Hsl1p, and that Hsl7p interacts physically with both Hsl1p and Swe1p. The authors suggest that Hsl7p acts as an adaptor to link Hsl1p and Swe1p.
21. Longtine M.S., Fares H., Pringle J.R. Role of the yeast Gin4p protein kinase in septin assembly and the relationship between septin assembly and septin function. J Cell Biol. 143:1998;719-736.
22. 2 delay. The authors suggest that Hsl1p forms part of a septin-monitoring checkpoint in yeast.
23. Okuzaki D., Tanaka S., Kanazawa H., Nojima H. Gin4 of S. cerevisiae is a bud neck protein that interacts with the Cdc28 complex. Genes Cells. 2:1997;753-770.
24. Hunter T., Plowman G.D. The protein kinases of budding yeast: six score and more. Trends Biochem Sci. 22:1997;18-22.
25. 2 delays associated with the generation of elongated buds. Perturbations that affect actin organization, however, do not cause delocalization of this module from the neck. We suggest that the location of the module serves to couple Swe1p degradation to bud formation.
26. Longtine M.S., DeMarini D.J., Valencik M.L., Al-Awar O.S., Fares H., De Virgilio C., Pringle J.R. The septins: roles in cytokinesis and other processes. Curr Opin Cell Biol. 8:1996;106-119.
27. Longtine M.S., Pringle J.R. Septins. Kreis T., Vale R. Guidebook to the Cytoskeletal and Motor Proteins. 1999;359-363 Oxford University Press, Oxford.
28. Field C.M., al-Awar O., Rosenblatt J., Wong M.L., Alberts B., Mitchison T.J. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. J Cell Biol. 133:1996;605-616.
29. Chant J., Mischke M., Mitchell E., Herskowitz I., Pringle J.R. Role of Bud3p in producing the axial budding pattern of yeast. J Cell Biol. 129:1995;767-778.
30. Sanders S.L., Herskowitz I. The Bud4 protein of yeast, required for axial budding, is localized to the mother/bud neck in a cell cycle-dependent manner. J Cell Biol. 134:1996;413-427.
31. DeMarini D.J., Adams A.E.M., Fares H., De Virgilio C., Valle G., Chuang J.S., Pringle J.R. A septin-based hierarchy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. J Cell Biol. 139:1997;75-93.
32. Bi E., Maddox P., Lew D.J., Salmon E.D., McMillan J.N., Yeh E., Pringle J.R. Involvement of an actomyosin contractile ring in Saccharomyces cerevisiae cytokinesis. J Cell Biol. 142:1998;1301-1312.
33. Lippincott J., Li R. Sequential assembly of myosin II, an IQGAP-like protein, and filamentous actin to a ring structure involved in budding yeast cytokinesis. J Cell Biol. 140:1998;355-366.
34. Byers B., Goetsch L. A highly ordered ring of membrane-associated filaments in budding yeast. J Cell Biol. 69:1976;717-721.
35. Yeh E., Skibbens R.V., Cheng J.W., Salmon E.D., Bloom K. Spindle dynamics and cell cycle regulation of dynein in the budding yeast, Saccharomyces cerevisiae. J Cell Biol. 130:1995;687-700.
36. Palmer R.E., Sullivan D.S., Huffaker T., Koshland D. Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae. J Cell Biol. 119:1992;583-593.
37. Muhua L., Adames N.R., Murphy M.D., Shields C.R., Cooper J.A. A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein. Nature. 393:1998;487-491.
38. 1-specific dynamics of microtubules. J Cell Biol. 145:1999;993-1007. This paper provides a detailed analysis of astral microtubule behavior in bim1 mutants, showing that such microtubules are shorter and less dynamic than those in wild-type cells. In addition, the authors show that, at endogenous levels of expression, Bim1p is concentrated at the presumed plus ends of astral microtubules.
39. Jaspersen S.L., Charles J.F., Tinker-Kulberg R.L., Morgan D.O. A late mitotic regulatory network controlling cyclin destruction in Saccharomyces cerevisiae. Mol Biol Cell. 9:1998;2803-2817.
40. Morgan D.O. Regulation of the APC and the exit from mitosis. Nat Cell Biol. 1:1999;E47-E53.
41. Bahler J., Steever A.B., Wheatley S., Wang Y., Pringle J.R., Gould K.L., McCollum D. Role of polo kinase and Mid1p in determining the site of cell division in fission yeast. J Cell Biol. 143:1998;1603-1616.
42. Sohrmann M., Schmidt S., Hagan I., Simanis V. Asymmetric segregation on spindle poles of the Schizosaccharomyces pombe septum-inducing protein kinase Cdc7p. Genes Dev. 12:1998;84-94.
43. Sparks C.A., Morphew M., McCollum D. Sid2p, a spindle pole body kinase that regulates the onset of cytokinesis. J Cell Biol. 146:1999;777-790.
44. Cerutti L., Simanis V. Asymmetry of the spindle pole bodies and spg1p GAP segregation during mitosis in fission yeast. J Cell Sci. 112:1999;2313-2321.
45. Li R. Bifurcation of the mitotic checkpoint pathway in budding yeast. Proc Natl Acad Sci USA. 96:1999;4989-4994. This paper shows that Bub2p and Byr4p are localized to the spindle pole bodies in S. cerevisiae and function in the same pathway to inhibit exit from mitosis.
46. Fraschini R., Formenti E., Lucchini G., Piatti S. Budding yeast Bub2 is localized at spindle pole bodies and activates the mitotic checkpoint via a different pathway from Mad2. J Cell Biol. 145:1999;979-991. This paper provides evidence that Bub2p acts in parallel to the other spindle-assembly-checkpoint proteins (rather than in the same pathway) to inhibit exit from mitosis. In addition, Bub2p is localized to the spindle pole bodies.
47. Huang S., Ingber D.E. The structural and mechanical complexity of cell growth control. Nat Cell Biol. 1:1999;E131-E138.
48. Feucht A., Daniel R.A., Errington J. Characterization of a morphological checkpoint coupling cell-specific transcription to septation in Bacillus subtilis. Mol Microbiol. 33:1999;1015-1026.
49. Le Goff X., Woollard A., Simanis V. Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe. Mol Gen Genet. 262:1999;163-172.