Structures of trihydroxynaphthalene reductase-fungicide complexes: Implications for structure-based design and catalysis

Structure

Volumn 9, Issue 1, 2001, Pages 19-27

  Liao, Der Ing ^a   Basarab, Gregory S ^a,b   Gatenby, Gregory S ^a   Valent, Barbara ^a   Jordan, Douglas B ^a  

^a DUPONT COMPANY   (United States)

^b ASTRAZENECA   (United Kingdom)

Author keywords

Catalysis; Fungal melanin biosynthesis; Inhibitors; Magnaporthe grisea; Short chain dehydrogenase; Structure based design; Substrate specificity

Indexed keywords

FUNGICIDE; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIHYDROXYNAPHTHALENE REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SPECIFICITY; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HYDROGEN BOND; PRIORITY JOURNAL; STEREOSPECIFICITY;

ANTIFUNGAL AGENTS; BINDING SITES; CATALYSIS; CATIONS; CRYSTALLOGRAPHY, X-RAY; FUNGAL PROTEINS; HYDROGEN; MAGNAPORTHE; MELANINS; MODELS, CHEMICAL; MODELS, MOLECULAR; NADP; NAPHTHALENES; OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; OXYGEN; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 0035152282     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00548-7     Document Type: Article

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