Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme’s catalytic mechanism and regulation by GDP-fucose

Structure

Volumn 8, Issue 2, 2000, Pages 123-135

  Somoza, John R ^a   Menon, Saurabh ^a   Schmidt, Holly ^a   Joseph Mccarthy, Diane ^a   Dessen, Andréa ^a   Stahl, Mark L ^a   Somers, William S ^a   Sullivan, Francis X ^a  

^a PFIZER INC   (United States)

Author keywords

Dehydratase; GDP fucose; GDP mannose; NADP; Short chain dehydrogenase reductase

Indexed keywords

GUANOSINE DIPHOSPHATE FUCOSE; GUANOSINE DIPHOSPHATE MANNOSE; HYDROLYASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0034651725     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00088-5     Document Type: Article

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