High-resolution structures of scytalone dehydratase-inhibitor complexes crystallized at physiological pH

Proteins: Structure, Function and Genetics

Volumn 35, Issue 4, 1999, Pages 425-439

  Wawrzak, Zdzislaw ^a,e   Sandalova, Tatyana ^b,c   Steffens, James J ^a   Basarab, Gregory S ^a   Lundqvist, Tomas ^d   Lindqvist, Ylva ^b   Jordan, Douglas B ^a  

^a DUPONT COMPANY   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c INSTITUTE OF BIOPHYSICS   (Russian Federation)

^d ASTRAZENECA R AND D   (Sweden)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Enzyme inhibitors; Fungicides; Melanin biosynthesis; Structure based design; X ray crystallography

Indexed keywords

HYDROLYASE; SCYTALONE DEHYDRATASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME STRUCTURE; FUNGUS; MELANOGENESIS; NONHUMAN; PH; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

BASE SEQUENCE; BINDING SITES; CALCIUM; CRYSTALLOGRAPHY, X-RAY; DNA PRIMERS; ENZYME INHIBITORS; HYDRO-LYASES; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 0033152666     PISSN: 08873585     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0134(19990601)35:4<425::AID-PROT6>3.0.CO;2-1     Document Type: Article

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