Tight binding inhibitors of scytalone dehydratase: Effects of site- directed mutations

Biochemistry

Volumn 39, Issue 29, 2000, Pages 8593-8602

  Jordan, Douglas B ^a   Basarab, Gregory S ^a   Steffens, James J ^a   Schwartz, Rand S ^a   Doughty, James G ^a  

^a DUPONT COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLYASE; HYDROLYASE INHIBITOR; MUTANT PROTEIN; SCYTALONE DEHYDRATASE; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME INHIBITION; ENZYME MECHANISM; HYDROGEN BOND; MAGNAPORTHE GRISEA; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDRO-LYASES; HYDROGEN BONDING; KINETICS; MAGNAPORTHE; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED;

MAGNAPORTHE GRISEA;

EID: 0034713887     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi000467m     Document Type: Article

References (39)

1. Bell, A. A., and Wheeler, M. H. (1986) Annu. Rev. Phytopath. 24, 411-451.
2. Chumley, F. G., and Valent, B. (1990) Mol. Plant-Microbe Interact. 3, 135-143.
3. Thompson, J. E., Basarab, G. S., Pierce, J., Hodge, C. N., and Jordan, D. B. (1998) Anal. Biochem. 256, 1-6.
4. Thompson, J. E., and Jordan, D. B. (1998) Anal. Biochem. 256, 7-13.
5. Jordan, D. B., Basarab, G. S., Steffens, J. J., Lundqvist, T., Pfrogner, B. R., Schwartz, R. S., and Wawrzak, Z. (1999) Pestic. Sci. 55, 277-280.
6. Basarab, G. S., Steffens, J. J., Wawrzak, Z., Schwartz, R. S., Lundqvist, T., and Jordan, D. B. (1999) Biochemistry 38, 6012-6024.
7. Steffens, J. J., Basarab, G. S., Schwartz, R. S., Lundqvist, T., Wawrzak, Z., and Jordan, D. B. (1999) in Modern Fungicides and Antifungal Compounds II (Lyr, H., Russell, P. E., Dehne, H.-W., and Sisler, H. D., Eds.) pp 121-130, Intercept Ltd., Andover, Hampshire, U.K.
8. Jordan, D. B., Zheng, Y.-J., Locket, B. A., and Basarab, G. S. (2000) Biochemistry 39, 2276-2282.
9. Howard, R. J., and Ferrari, M. A. (1989) Exp. Mycol. 13, 403-418.
10. Howard, R. J., and Valent, B. (1996) Annu. Rev. Microbiol. 50, 491-512.
11. Ou, S. H. (1985) in Rice Diseases, 2nd ed., pp 109-201, C. A. B. International, Slough, U.K.
12. Andersson, A., Jordan, D. B., Schneider, G., and Lindqvist, Y. (1996) Structure (London) 4, 1161-1170.
13. Thompson, J. E., Basarab, G. S., Andersson, A., Lindqvist, Y., and Jordan, D. B. (1997) Biochemistry 36, 1852-1860.
14. Liao, D.-I., Basarab, G. S., Gatenby, A. A., and Jordan, D. B. (2000) Bioorg. Med. Chem. Lett. 10, 491-494.
15. Jornvall, H., Persson, B., Krook, M., Atrian, S., Gonzalez-Duarte, R., Jeffrey, J., and Ghosh, D. (1995) Biochemistry 34, 6003-6013.
16. Kurahashi, Y., Sakawa, S., Kinbara, T., Tanaka, K., and Kagabu, S. (1997) Nippon Noyaku Gakkaishi 22, 108-112.
17. Tsuji, G., Takeda, T., Furusawa, I., Horino, O., and Kubo, Y. (1997) Pestic. Biochem. Physiol., 57, 211-219.
18. Agrow (1997) Vol. 287, pp 21-22, PJP Publications Ltd.
19. Sieverding, E., Hirooka, T., Nishiguchi, T., Yamamoto, Y., Spadafora, V. J., and Hasui, H. (1998) in Proceedings of the 1998 Brighton Conference - Pests and Diseases, Vol. 2, pp 359-366, British Crop Protection Council, Brighton, England.
20. Chen, J. M., Xu, S. L., Wawrzak, Z., Basarab, G. S., and Jordan, D. B. (1998) Biochemistry 37, 17735-17744.
21. Wawrzak, Z., Sandalova, T., Steffens, J. J., Basarab, G. S., Lundqvist, T., Lindqvist, Y., and Jordan, D. B. (1999) Proteins: Struct., Funct., Genet. 35, 425-439.
22. Jordan, D. B., Lessen, T., Wawrzak, Z., Bisaha, J. J., Gehret, T. C., Hansen, S. L., Schwartz, R. S., and Basarab, G. S. (1999) Bioorg. Med. Chem. Lett. 9, 1607-1612.
23. Basarab, G. S., Jordan, D. B., Gehret, T. C., Schwartz, R. S., and Wawrzak, Z. (1999) Bioorg. Med. Chem. Lett. 9, 1613-1618.
24. Jennings, L. D., Wawrzak, Z., Amorose, D., Schwartz, R. S., and Jordan, D. B. (1999) Bioorg. Med. Chem. Lett. 9, 2509-2514.
25. Jennings, L. D., Rayner, D. R., Jordan, D. B., Okonya, J., Basarab, G. S., Amorose, D. K., Anacelerio, B. M., Gehret, T. C., Lee, J. K., Schwartz, R. S., and Whitmore, K. A. (2000) Bioorg. Med. Chem. 8, 897-907.
26. Gerlt, J. A., Kozarich, J. W., Kenyon, G. L., and Gassman, P. G. (1991) J. Am. Chem. Soc. 113, 9667-9669.
27. Gerlt, J. A., and Gassman, P. G. (1992) J. Am. Chem. Soc. 114, 5928-5934.
28. Gerlt, J. A., and Gassman, P. G. (1993) Biochemistry 32, 11943-11952.
29. Anderson, V. E. (1998) in Comprehensive Biological Catalysts, Vol. 2, pp 115-133, Academic Press, New York.
30. Basarab, G. S., Jordan, D. B., and Zheng, Y.-J. (2000) Org. Lett. 2, 1541-1544.
31. Lundqvist, T., Rice, J., Hodge, C. N., Basarab, G. S., Pierce, J., and Lindqvist, Y. (1994) Structure (London) 2, 937-944.
32. Lundqivst, T., Weber, P. C., Hodge, C. N., Braswell, E. H., Rice, J., and Pierce, J. (1993) J. Mol. Biol. 232, 999-1002.
33. Sambrook, J., Fritsch, E. F., and Maniatis, T. (1989) Molecular Cloning. A Laboratory Manual, 2nd ed., Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
34. Aiyar, A., and Leis, J. (1993) BioTechniques 14, 366-368.
35. Basarab, G. S., and Jordan, D. B. (1999) Biochem. Biophys. Res. Commun. 263, 617-620.
36. Genetic Computer Group (1994) in Program Manual for the Wisconsin Package, version 8, Genetic Computer Group, Madison, WI.
37. Hodge, C. N., and Pierce, J. (1993) Bioorg. Med. Chem. Lett. 3, 1605-1608.
38. Jordan, D. B., and Basarab, G. S. (2000) Bioorg. Med. Chem. Lett. 10, 23-26.
39. Gomez, J., and Freire, E. (1995) J. Mol. Biol. 252, 337-350.