Catalytic mechanism of scytalone dehydratase: Site-directed mutagenisis, kinetic isotope effects, and alternate substrates

Biochemistry

Volumn 38, Issue 19, 1999, Pages 6012-6024

  Basarab, Gregory S ^a   Steffens, James J ^a   Wawrzak, Zdzislaw ^a,c   Schwartz, Rand S ^a   Lundqvist, Tomas ^b   Jordan, Douglas B ^a  

^a DUPONT COMPANY   (United States)

^b ASTRAZENECA R AND D   (Sweden)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROLASE; SCYTALONE DEHYDRATASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; REACTION ANALYSIS; SITE DIRECTED MUTAGENESIS; STEADY STATE; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION;

BENZOPYRANS; BINDING SITES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HYDRO-LYASES; HYDROGEN-ION CONCENTRATION; KINETICS; MAGNAPORTHE; MUTAGENESIS, SITE-DIRECTED; NAPHTHOLS; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY;

FELIS CATUS;

EID: 0033545895     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982952b     Document Type: Article

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