Polyomavirus T antigens: Molecular chaperones for multiprotein complexes

Journal of Virology

Volumn 72, Issue 7, 1998, Pages 5329-5334

  Brodsky, Jeffrey L ^a   Pipas, James M ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CHAPERONE; VIRUS T ANTIGEN;

DNA REPLICATION; DNA TRANSCRIPTION; NONHUMAN; POLYOMA VIRUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; SHORT SURVEY; VIRION; VIRUS INFECTION; VIRUS TRANSFORMATION;

EID: 0031746554     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.72.7.5329-5334.1998     Document Type: Short Survey

References (57)

1. Alfano, C., and R. McMacken. 1989. Heat shock protein-mediated disassembly of nucleoprotein structures is required for the initiation of bacteriophage λ replication. J. Biol. Chem. 264:10709-10718.
2. Brodsky, J. L. 1996. Post-translational protein translocation: not all Hsp70s are created equal. Trends Biochem. Sci. 21:121-126.
3. Campbell, K. S., K. P. Mullane, I. A. Aksoy, H. Stubdal, J. Zalvide, J. M. Pipas, P. A. Silver, T. M. Roberts, B. S. Schaffhausen, and J. A. DeCaprio. 1997. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 11:1098-1110.
4. Cheetham, M. E., J. P. Brion, and B. H. Anderton. 1992. Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons. Biochem. J. 284:469-476.
5. Chen, J., G. J. Tobin, J. M. Pipas, and T. Van Dyke. 1992. T antigen mutant activities in vivo: roles of p53 and pRB binding in tumorigenesis of the choroid plexus. Oncogene 7:1167-1175.
6. Cole, C. N. 1996. Polyomavirinae: the viruses and their replication, p. 1997-2026. In B. Fields et al. (ed.), Virology, 3rd ed. Lippincott-Raven, New York, N.Y.
7. Collins, B. S., and J. M. Pipas. 1995. T antigens encoded by replication-defective SV40 mutants dl1135 and 5080. J. Biol. Chem. 270:15377-15384.
8. Conzen, S. D., and C. N. Cole. 1995. The three transforming regions of SV40 T antigen are required for immortalization of primary mouse embryo fibroblasts. Oncogene 11:2295-2302.
9. Damania, B., and J. C. Alwine. 1996. TAF-like function of SV40 large T antigen. Genes Dev. 10:1369-1381.
10. Flaherty, K. M., C. DeLuca-Flaherty, and D. B. McKay. 1990. Three dimensional structure of the ATPase fragment of a 70K heat shock cognate protein. Nature 346:623-628.
11. Gaitanaris, G. A., A. G. Papavassiliou, P. Rubock, S. J. Silverstein, and M. E. Gottesman. 1990. Renaturation of denatured λ repressor requires heat shock proteins. Cell 61:1013-1020.
12. 32. Cell 69:833-842.
13. Georgopoulos, C., K. Liberek, M. Zylicz, and D. Ang. 1994. Properties of the heat shock proteins of Escherichia coli and the autoregulation of the heat shock response, p. 209-249. In R. I. Morimoto, A. Tessieres, and C. Georgopoulos (ed.), The biology of heat shock proteins and molecular chaperones. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
14. Gluzman, Y., and B. Ahrens. 1982. SV40 early mutants that are defective for viral DNA synthesis but competent for transformation of cultured rat and simian cells. Virology 22:78-92.
15. Gottesman, S., S. Wickner, and M. R. Maurizi. 1997. Protein quality control: triage by chaperones and proteases. Genes Dev. 11:815-823.
16. Hartl, F. U. 1996. Molecular chaperones in cellular protein folding. Nature 381:571-580.
17. 15N magnetic resonance assignments, secondary structure, and tertiary fold of Escherichia coli DnaJ(1-78). Biochemistry 34:5587-5596.
18. Johnston, S. D., X. M. Yu, and J. E. Mertz. 1996. The major transcriptional transactivation domain of simian virus 40 large T antigen associates nonconcurrently with multiple components of the transcriptional preinitiation complex. J. Virol. 70:1191-1202.
19. Kelley, W. L., and S. J. Landry. 1994. Chaperone power in a virus? Trends Biochem. Sci. 19:277-278.
20. Kelley, W. L., and C. Georgopolous. 1997. The T/t common exon of SV40, JCV, and BK polyomavirus T antigens can functionally replace the J-domain of the Escherichia coli DnaJ molecular chaperone. Proc. Natl. Acad. Sci. USA 94:3679-3684.
21. Langer, T., C. Lu, H. Echols, J. Flanagan, M. K. Bayer, and F. U. Hartl. 1992. Successive action of dnaK, dnaJ and GroEL along the pathway of chaperone-mediated folding. Nature 356:683-689.
22. Liberek, K., J. Marszalek, D. Ang, C. Georgopoulos, and M. Zylicz. 1991. Escherichia coli dnaJ and grpE heat shock proteins jointly stimulate ATPase activity of dnaK. Proc. Natl. Acad. Sci. USA 88:2874-2878.
23. Lill, N. I., M. J. Tevethia, R. Eckner, D. M. Livingston, and N. Modjtahedi. 1997. p300 family members associate with the carboxy terminus of simian virus 40 large tumor antigen. J. Virol. 71:129-137.
24. Liu, J.-S., S.-R. Kuo, D. M. Cyr, T. R. Broker, and L. T. Chow. Personal communication.
25. Maulbecker, C., I. Mohr, Y. Gluzman, J. Bartholomew, and M. Botchan. 1992. A deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen. J. Virol. 66:2195-2207.
26. McCarty, J. S., A. Buchberger, J. Reinstein, and B. Bukau. 1995. The role of ATP in the functional cycle of the DnaK chaperone system. J. Mol. Biol. 249: 126-137.
27. Messerschmitt, A. S., N. Dunant, and K. Ballmer-Hofer. 1997. DNA tumor viruses and src family tyrosine kinases, an intimate relationship. Virology 227:271-280.
28. Munger, K. Personal communication.
29. Peden, K. W. C., and J. M. Pipas. 1992. Simian virus 40 mutants with amino-acid substitutions near the amino-terminus of large T antigen. Virus Genes 6:107-118.
30. Pellecchia, M., T. Szyperski, D. Wall, C. Georgopolous, and K. Wüthrich. 1996. NMR structure of the J-domain and the Gly/Phe-rich region of the Escherichia coli DnaJ chaperone. J. Mol. Biol. 260:236-250.
31. Pipas, J. M. 1992. Common and unique features of T antigens encoded by the polyomavirus group. J. Virol. 66:3979-3985.
32. Pipas, J. M., K. W. C. Peden, and D. Nathans. 1983. Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene. Mol. Cell. Biol. 3:203-213.
33. Porras, A., J. Bennett, A. Howe, K. Tokos, N. Bouck, B. Henglein, S. Sathyamangalam, B. Thimmapaya, and K. Rundell. 1996. A novel simian virus 40 early-region domain mediates transactivation of the cyclin A promoter by small-t antigen and is required for transformation in small-t antigen-dependent assays. J. Virol. 70:6902-6908.
34. Qian, Y. Q., D. Patel, F.-U. Hartl, and D. J. McColl. 1996. Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain. J. Mol. Biol. 260:224-235.
35. Quartin, R. S., C. N. Cole, J. M. Pipas, and A. J. Levine. 1994. The amino-terminal functions of the simian virus 40 large T-antigen are required to overcome wild-type p53-mediated growth arrest of cells. J. Virol. 68:1334-1341.
36. Riley, M. I., W. Yoo, N. Y. Mda, and W. R. Folk. 1997. Tiny T antigen: an autonomous polyomavirus T antigen amino-terminal domain. J. Virol. 71: 6068-6074.
37. Sawai, E. T., and J. S. Butel. 1989. Association of a cellular heat shock protein with simian virus 40 large T antigen in transformed cells. J. Virol. 63: 3961-3973.
38. Sawai, E. T., G. Rasmussen, and J. S. Butel. 1994. Construction of SV40 deletion mutants and delimitation of the binding domain for heat shock protein to the amino terminus of large T-antigen. Virus Res. 31:367-378.
39. Schröder, H., T. Langer, F.-U. Hartl, and B. Bukau. 1993. DnaK, DnaJ, and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage. EMBO J. 12:4137-4144.
40. Sheng, Q., D. Denis, M. Ratnofsky, T. M. Roberts, J. A. DeCaprio, and B. Schaffhausen. 1997. The DnaJ domain of polyomavirus large T antigen is required to regulate Rb family tumor suppressor function. J. Virol. 71: 9410-9416.
41. Skowyra, D., C. Georgopoulos, and M. Zylicz. 1990. The E. coli dnaK gene product, the hsp70 homolog, can reactivate heat-inactivated RNA polymerase in an ATP hydrolysis-dependent manner. Cell 62:939-944.
42. Spence, S. L., and J. M. Pipas. 1994. SV40 large T antigen functions at two distinct steps in viron assembly. Virology 204:200-209.
43. Srinivasan, A., A. J. McClellan, J. Vartikar, I. Marks, P. Cantalupo, Y. Li, P. Whyte, K. Rundell, J. L. Brodsky, and J. M. Pipas. 1997. The amino-terminal transforming region of simian virus 40 large and small T antigens function as a J-domain. Mol. Cell. Biol. 17:4761-4773.
44. Stubdal, H., J. Zalvide, K. S. Campbell, C. Schweitzer, T. M. Roberts, and J. A. DeCaprio. 1997. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol. Cell. Biol. 17:4979-4990.
45. Stubdal, H., J. Zalvide, and J. A. DeCaprio. 1996. Simian virus 40 large T antigen alters the phosphorylation state of the RB-related proteins p130 and p107. J. Virol. 70:2781-2788.
46. Symonds, H. S., S. A. McCarthy, J. Chen, J. M. Pipas, and T. Van Dyke. 1993. Use of transgenic mice reveals cell-specific transformation by a simian virus 40 T-antigen amino-terminal mutant. Mol. Cell. Biol. 13:3255-3265.
47. Szyperski, T., M. Pellecchia, D. Wall, C. Georgopolous, and K. Wüthrich. 1994. NMR structure determination of the Escherichia coli DnaJ molecular chaperone: secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain. Proc. Natl. Acad. Sci. USA 91:11343-11347.
48. Tevethia, M. J., H. A. Lacko, T. D. Kierstead, and D. L. Thompson. 1997. Adding an Rb-binding site to an N-terminally truncated simian virus 40 T antigen restores growth to high cell density, and the T common region in trans provides anchorage-independent growth and rapid growth in low serum concentrations. J. Virol. 71:1888-1896.
49. Van Dyke, T. Personal communication.
50. Weisshart, K., M. K. Bradley, B. M. Weiner, C. Schneider, I. Moarefi, E. Fanning, and A. K. Arthur. 1996. An N-terminal deletion mutant of simian virus (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase alpha and replicate SV40 DNA in vitro. J. Virol. 70:3509-3516.
51. Wickner, S., J. Hoskins, and K. McKenney. 1991. Function of DnaJ and DnaK as chaperones in origin-specific DNA binding by RepA. Nature 350: 165-167.
52. Yaciuk, P., M. C. Carter, J. M. Pipas, and E. Moran. 1991. Simian virus 40 large T antigen expresses a biological activity complementary to the p300-associated transforming function of the adenovirus E1A gene products. Mol. Cell. Biol. 11:2116-2124.
53. Zalvide, J., H. Stubdal, and J. A. DeCaprio. 1998. The J domain of simian virus 40 large T antigen is required to functionally inactivate RB family proteins. Mol. Cell. Biol. 18:1408-1415.
54. Zerrahn, J., U. Knippschild, T. Winkler, and W. Deppert. 1993. Independent expression of the transforming amino-terminal domain of SV40 large T antigen from an alternatively spliced third SV40 early mRNA. EMBO J. 12: 4739-4746.
55. Zhu, J., P. W. Rice, L. Gorsch, M. Abate, and C. N. Cole. 1992. Transformation of a continuous rat embryo fibroblast cell line requires three separate domains of simian virus 40 large T antigen. J. Virol. 66:2780-2791.
56. Zhu, X., X. Zhao, W. F. Burkholder, A. Gragerov, C. M. Ogata, M. E. Gottesman, and W. A. Hendrickson. 1996. Structural analysis of substrate binding by the molecular chaperone DnaK. Science 272:1606-1614.
57. Zylicz, M., D. Ang, K. Liberek, and C. Georgopoulos. 1989. Initiation of λ DNA replication with purified host and bacteriophage encoded proteins: the role of the dnaK, dnaJ, and grpE heat shock proteins. EMBO J. 8:1601-1608.