Identification of regions in HIV-1 Nef required for efficient downregulation of cell surface CD4

Virology

Volumn 231, Issue 2, 1997, Pages 231-238

  Hua, Jian ^a   Blair, Wade ^a   Truant, Ray ^a   Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEF PROTEIN; VIRUS PROTEIN;

AMINO TERMINAL SEQUENCE; ARTICLE; DOWN REGULATION; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ACTIVITY RELATION; VIRION;

EID: 0030958508     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8517     Document Type: Article

References (30)

1. Aiken C., Konner J., Landau N. R., Lenburg M. E., Trono D. Nef induces CD4 endocytosis: Requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain. Cell. 76:1994;853-864.
2. Aiken C., Krause L., Chen Y.-L., Trono D. Mutational analysis of HIV-1 Nef: Identification of two mutants that are temperature-sensitive for CD4 downregulation. Virology. 217:1996;293-300.
3. Aiken C., Trono D. Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis. J. Virol. 69:1995;5048-5056.
4. Anderson S., Shugars D. C., Swanstrom R., Garcia J. V. Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells. J. Virol. 67:1993;4923-4931.
5. Bandres J. C., Ratner L. Human immunodeficiency virus type 1 Nef protein down-regulates transcription factors NF-κB and AP-1 in human T cellsin vitro. J. Virol. 68:1994;3243-3249.
6. Baur A. S., Sawai E. T., Dazin P., Fantl W .J., Cheng-Mayer C., Peterlin B. M. HIV-1 Nef leads to inhibition of activation of T cells depending on its intracellular localization. Immunity. 1:1994;373-384.
7. Benson R. E., Sanfridson A., Ottinger J. S., Doyle C., Cullen B. R. Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection. J. Exp. Med. 177:1993;1561-1566.
8. Chowers M. Y., Spina C. A., Kwoh T. J., Fitch N. J. S., Richman D. D., Guatelli J. C. Optimal infectivityin vitronef. J. Virol. 68:1994;2906-2914.
9. Cullen B. R. Trans. Cell. 46:1986;973-982.
10. Cullen B. R. The role of Nef in the replication cycle of the human and simian immunodeficiency viruses. Virology. 205:1994;1-6.
11. Cullen B. R., Podlaski F. J., Peffer N. J., Hosking J. B., Greene W. C. Sequence requirements for ligand binding and cell surface expression of the Tac antigen, a human interleukin-2 receptor. J. Biol. Chem. 263:1988;4900-4906.
12. De Ronde A., Klaver B., Keulen W., Smit L., Goudsmit J. Natural HIV-1 Nef accelerates virus replication in primary human lymphocytes. Virology. 188:1992;391-395.
13. Du Z., Lang S. M., Sasseville V. G., Lackner A. A., Ilyinskii P. O., Daniel M. D., Jung J. U., Desrosiers R. C. Identification of anef. Cell. 82:1995;665-674.
14. Garcia J. V., Miller A. D. Serine phosphorylation-independent downregulation of cell-surface CD4 bynef. Nature. 350:1991;508-511.
15. Goldsmith M. A., Warmerdam M. T., Atchison R. E., Miller M. D., Greene W. C. Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef. J. Virol. 69:1995;4112-4121.
16. Grzesiek S., Bax A., Clore G. M., Gronenborn A. M., Hu J.-S., Kaufman J., Palmer I., Stahl S. J., Wingfield P. T. The solution structure of HIV-1 Nef reveals an unexpected fold and permits delineation of the binding surface for the SH3 domain of Hck tyrosine protein kinase. Nature Struct. Biol. 3:1996;340-345.
17. Hammes S. R., Dixon E. P., Malim M. H., Cullen B. R., Greene W. C. Nef protein of human immunodeficiency virus type 1: Evidence against its role as a transcriptional inhibitor. Proc. Natl. Acad. Sci. USA. 86:1989;9549-9553.
18. Jamieson B. D., Aldrovandi G. M., Planelles V., Jowett J. B. M., Gao L., Bloch L. M., Chen I. S. Y., Zack J. A. Requirement of human immunodeficiency virus type 1nefin vivo. J. Virol. 68:1994;3478-3485.
19. Kestler H. W. III, Ringler D. J., Mori K., Panicali D. L., Sehgal P. K., Daniel M. D., Desrosiers R. C. Importance of thenef. Cell. 65:1991;651-662.
20. Lee C.-H., Saksela K., Mirza U. A., Chait B. T., Kuriyan J. Crystal structure of the conserved core of HIV-1 Nef complexed with a Src family SH3 domain. Cell. 85:1996;931-942.
21. Mariani R., Skowronski J. CD4 down-regulation bynef. Proc. Natl. Acad. Sci. USA. 90:1993;5549-5553.
22. Miller M. D., Warmerdam M. T., Gaston I., Greene W. C., Feinberg M. B. The human immunodeficiency virus-1nef. J. Exp. Med. 179:1994;101-113.
23. Rhee S. S., Marsh J. W. Human immunodeficiency virus type 1 Nef-induced downmodulation of CD4 is due to rapid internalization and degradation of surface CD4. J. Virol. 68:1994;5156-5163.
24. -. Virology. 213:1995;158-168.
25. +. EMBO J. 14:1995;484-489.
26. Sawai E. T., Baur A. S., Peterlin B. M., Levy J. A., Cheng-Mayer C. A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity. J. Biol. Chem. 270:1995;15307-15314.
27. Shugars D. C., Smith M. S., Glueck D. H., Nantermet P. V., Seillier-Moiseiwitsch F., Swanstrom R. Analysis of human imunodeficiency virus type 1nefin vivo. J. Virol. 67:1993;4639-4650.
28. Spina C. A., Kwoh T. J., Chowers M. Y., Guatelli J. C., Richman D. D. The importance ofnef. J. Exp. Med. 179:1994;115-123.
29. Wiskerchen M., Cheng-Mayer C. HIV-1 Nef association with cellular serine kinase correlates with enhanced virion infectivity and efficient proviral DNA synthesis. Virology. 224:1996;292-301.
30. Zazopoulos E., Haseltine W. A. Mutational analysis of the human immunodeficiency virus type 1 Eli Nef function. Proc. Natl. Acad. Sci. USA. 89:1992;6634-6638.