Role of IL-6 in the pleurisy and lung injury caused by carageenan

Journal of Immunology

Volumn 163, Issue 9, 1999, Pages 5094-5104

  Cuzzocrea, Salvatore ^a   Sautebin, Lidia ^b   De Sarro, Giovambattista ^c   Costantino, Giuseppina ^a   Rombolà, Laura ^b   Mazzon, Emanuela ^a   Ialenti, Armando ^b   De Sarro, Angela ^a   Ciliberto, Gennaro ^d   Di Rosa, Massimo ^b   Caputi, Achille P ^a   Thiemermann, Christoph ^e  

^a UNIVERSITY OF MESSINA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^d Inst di Richerche di Biol Molec   (Italy)

^e ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARRAGEENAN; INTERLEUKIN 6;

ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL MIGRATION; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; KNOCKOUT MOUSE; LIPID PEROXIDATION; LUNG INJURY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PLEURA FLUID; PLEURISY; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE SECTION;

ANIMALS; CARRAGEENAN; CELLS, CULTURED; CYTOKINES; DINOPROSTONE; DNA DAMAGE; ENZYME INDUCTION; INTERLEUKIN-6; LEUKOTRIENE B4; LUNG; MACROPHAGES; MALE; MALONDIALDEHYDE; MICE; MICE, KNOCKOUT; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PEROXIDASE; PLEURA; PLEURISY; POLY(ADP-RIBOSE) POLYMERASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS F; TYROSINE;

EID: 0032737345     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Vane, J., and R. Botting. 1987. Inflammation V and the mechanism of action of antiinflammatory drugs. FASEB J. 1:89.
2. Baumann, H., G. Jahreis, D. N. Sander, and A. Koj. 1984. Human keratinocytes and monocytes release factors which regulate the synthesis of major acute phase plasma proteins in hepatic cells from man, rat, and mouse. J. Biol. Chem. 262:9756.
3. Jirik, F. R., T. J. Podor, T. Hirano, T. Kishimoto, D. J. Loskutoff, D. A. Carson, and M. Lotz. 1989. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J. Immunol. 142:144.
4. Nijsten, M. W., E. R. de Groot, H. J. ten Duis, H. J. Klasen, C. E. Hack, and L. A. Aarden. 1987.Serum levels of interleukin-6 and acute phase responses. Lancet 17:2.
5. Nishimoto, N., K. Yoshizaki, H. Tagoh, M. Monden, S. Kishimoto, T. Hirano, and T. Kishimoto. 1989. Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation. Clin. Immunol. Immuno-pathol. 50:399.
6. Helfgott, D. C., S. B. Tatter, U. Santhanam, R. H. Clarick, N. Bhardwaj, L. T. May, and P. B. Sehgal. 1989. Multiple forms of IFN-β2/IL-6 in serum and body fluids during acute bacterial infection. J. Immunol. 142:948.
7. Nishimoto, N., K. Yoshizaki, H. Tagoh, M. Monden, S. Kishimoto, T. Hirano, and T. Kishimoto. 1985. Elevation of serum interleukin 6 prior to acute phase proteins on the inflammation by surgical operation. Clin. Immunol. Immunopathol. 50:399.
8. Hirano, T., T. Matsuda, M. Turner, N. Jiyasaka, G. Buchan, B. Tang, K. Sato, M. Shimizu, R. Maini, M. Feldmann, et al. 1988. Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur. J. Immunol. 18:1797.
9. Waage, A., A. Halstensen, R. Shalaby, P. Brandtzaeg, P. Kierulf, and T. Espevik .1989. Local production of tumor necrosis factor a, interleukin 1, and interleukin 6 in meningococcal meningitis: relation to the inflammatory response. J. Exp. Med. 170:1859.
10. Gilhar, A., M. David, R. S. Kalish, and G. Weisinger. In vivo effects of cytokines on psoriatic skin grafted on nude mice: involvement of the tumour necrosis factor (TNF) receptor. Clin. Exp. Immunol. 106:134.
11. Alonzi, T., E. Fattori, M. Cappelletti, G. Ciliberto, and V. Poli. 1998. Impaired stat3 activation following localized inflammatory stimulus in IL-6 deficient mice. Cytokine 10:13.
12. Romano, M., M. Sironi, C. Toniatti, N. Polentarutti, P. Fruscella, P. Ghezzi, R. Faggioni, W. Luini, V. van Hinsbergh, S. Sozzani, et al. 1997. Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6:315.
13. Alonzi, T., E. Fattori, D. Lazzaro, P. Costa, L. Probert, G. Kollias, F. De Benedetti, V. Poli, and G. Ciliberto. 1998. Interleukin-6 is required for the development of collagen-induced arthritis. J. Exp. Med., 187:461.
14. Poli, V., R. Balena, E. Fattori, A. Markatos, M. Yamamoto, H. Tanaka, G. Ciliberto, G. A. Rodan, and F. Costantini. 1994. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion. EMBO 13:1189.
15. Tilg, H., C. A. Dinarello, and J. W. Mier. 1997. II-6 and APPs: anti-inflammatory and immunosuppressive mediators. Immunology 18:428.
16. Van De Loo, F. A. J., L. A. B. Joosten, P. L. E. M. Van Lent, O. J. Arntz, and W. B. Van Den Berg. 1995.Role of interleukine-1, tumor necrosis factor, and interleukine-6 in cartilage proteoglycan metabolism and destruction. Arthritis Rheum. 38:164.
17. Van de Loo, F. A., O. J. Arntz, and W. B. Van den Berg. 1997. Effect of interleukin 1 and leukaemia inhibitory factor on chondrocyte metabolism in articular cartilage from normal and interleukin-6-deficient mice: role of nitric oxide and IL-6 in the suppression of proteoglycan synthesis. Cytokine 9:453.
18. Cuzzocrea, S., B. Zingarelli, G. Costantino, and A. P. Caputi. 1999. Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in carrageenan-induced pleurisy. Free Radical Biol. Med. 23:25.
19. Cuzzocrea, S., B. Zingarelli, L. Sautebin, A. Rizzo, G. Crisafulli, G. M. Campo, G. Costantino, G. Calapai, F. Nava, M. Di Rosa, et al. 1997. Multiple organ failure following zymosan-induced peritonitis is mediated by nitric oxide. Shock 4:268.
20. Sautebin, L., A. Ialenti, A. Ianaro, and M. Di Rosa. 1995. Modulation by nitric oxide of prostaglandin biosynthesis in the rat. Br. J. Pharmacol. 114:323.
21. Bradford, M. M.1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248.
22. Tomlinson, A., I. Appleton, A. L. Moore, D.W. Gilroy, D. Willis, J. A. Mitchell, and D. A. Willoughby. 1994. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenan-induced pleurisy. Br. J. Pharmacol. 113:693.
23. Mullane, K. M., W. Westlin, and R. Kraemer. 1988. Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion. Ann. NY Acad. Sci. 524:103.
24. Ohkawa, H., N. Ohishi, and K. Yagi. 1979.Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 95:351.
25. Utsunomiya, I., S. Nagai, and S. Oh-ishi. Sequential appearance of IL-1 and IL-6 activities in rat carrageenan-induced pleurisy. J. Immunol. 147:1803.
26. Oh-Ishi, S., I. Hayashi, M. Hayashi, K. Yamaki, and I. Utsunomiya. 1989. Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: rat pleurisy induced by carrageenan and phorbol myristate acetate. Dermatologica 179(Suppl. 1):68.
27. Salvemini, D., Z. Q. Wang, P. Wyatt, D. M. Bourdon, M. H. Marino, P. T. Manning, and M. G. Currie. 1996. Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation. Br. J. Pharmacol. 118:829.
28. Da Motta, J. I., F. G. Cunha, B. B.Vargaftig, and S. H. Ferreira. 1994. Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletion. Br. J. Pharmacol. 112:111.
29. Cuzzocrea, S., B. Zingarelli, E. Gilard, P. Hake, A. L. Salzman, and C. Szabò. 1997d. Protective effect of melatonin in carrageenan-induced models of local inflammation. J. Pineal Res. 23:106.
30. Tracey, W. R., M. Nakane, J. Kuk, G. Budzik, V. Klinghofer, R. Harris, and G. Carter. 1995. The nitric oxide synthase inhibitor, L-NG-monomethylarginine, reduces carrageenan-induced pleurisy in the rat. J. Pharmacol. Exp. Ther. 273:1295.
31. Wei, X. Q., I. G. Charles, A. Smith, J. Ure, G. H. Feng, F. P. Huang, D. Xu, W. Muller, S. Moncada, and F. Y. Liew. 1995. Altered immune responses in mice lacking inducible nitric oxide synthase. Nature 375:408.
32. Cuzzocrea, S., B. Zingarelli, E. Gilard, P. Hake. A. L. Salzman, and C. Szabó. 1998a. Anti-inflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammation. Free Radical Biol. Med. 24:450.
33. Thiemermann, C., C. Wu, C. C. Szabo, C. Perretti, M. Vane, and J. R. 1993. Role of tumour necrosis factor in the induction of nitric oxide synthase in a rat model of endotoxin shock. Br. J. Pharmacol. 110:177.
34. Szabo, C., C. C. Wu, S. S. Gross, C. Thiemermann, and J. R. Vane. 1993. Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo. Eur. J. Pharmacol. 250:157.
35. Salvemini, D., P. Z. Manning, B. S. Zweifel, K. Seibert, J. Connor, M. G. Currie, P. Needleman, and J. L. Masferrer. 1995. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J. Clin. Invest. 1 96:307.
36. Sautebin, L., A. Ialenti, and M. Di Rosa. 1998. Relationship between nitric oxide and prostaglandins in carrageenan pleurisy. Biochem. Pharmacol. 55:1113.
37. Mitchell, J. A., P. Akarasereenont, C. Thiemermann, R. J. Flower, and J. R. Vane. 1993. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 24:11693.
38. 2 formation in rat carrageenan-induced pleurisy. Prostaglandin 51:19.
39. Futaki, N., I. Aral, Y. Hamasaka, S. Takahashi, S. Higuchi, and S. Otomo. 1993. Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation. J. Pharm. Pharmacol. 45:753.
40. Beckman, J. S., T. W. Beckman, J. Chen, P. A. Marshall, and B. A. Freman. 1990. Apparent hydroxyl radical production by peroxynitrite: implication for endothelial injury from nitric oxide and superoxide. Proc. Natl. Acad. Sci. USA 87:1620.
41. Rubbo, H., R. Radi, M. Trujillo, R. Telleri, B. Kalyanaraman, S. Barnes, M. Kirk, and B. A. Freeman. 1994. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: formation of novel nitrogen-containing oxidised lipid derivatives. J. Biol. Chem. 269:26066.
42. Graham, A., Hogg, N., B. Kalyanaraman, V. O'Leary, V. Darley-Usmar, and S. Moncada. 1993. Peroxynitrite modification of low density lipoprotein leads to recognition by the macrophage scavenger receptor. FEBS Lett. 330:18.
43. Beckman, J. S. 1996. Oxidative damage and tyrosine nitration from peroxynitrite. Chem. Res. Toxicol. 9:836.
44. Eiserich, J. P., M. Hristova, C. E. Cross, A. D. Jones, B. A. Freeman, B. Halliwell, and A. Van Der Vliet.1998. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase neutrophils. Nature 391:393.
45. Szabó, C., L. H. K. Lim, S. Cuzzocrea, S. J. Getting, B. Zingarelli, R. J. Flower, A. L. Salzman, and M. Perretti. 1997. Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment. J. Exp. Med. 186:1041.
46. Szabó, C., L. Viràg, S. Cuzzocrea, G. S. Scott, P. Hake, M. O'Connor, B. Zingarelli, Y. Ma. R. Hirsch, G. P. Boiovin, et al. 1998. Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-ribose) synthetase. Proc. Natl. Acad. Sci. USA 95:3867.
47. Cuzzocrea, S., A. P. Caputi, and B. Zingarelli. 1998b. Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisy. Immunology 93:96.
48. Cuzzocrea, S., B. Zingarelli, E. Gilard, P. Hake, A. L. Salzman, and C. Szabó. 1998c. Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in carrageenan-induced models of local inflammation. Eur. J. Pharmacol. 342:67.