Interleukin-12 promotes pathologic liver changes and death in mice coinfected with Schistosoma mansoni and Toxoplasma gondii

Infection and Immunity

Volumn 69, Issue 3, 2001, Pages 1454-1462

  Araujo, M I ^a   Bliss, S K ^a   Suzuki, Y ^a   Alcaraz, A ^a   Denkers, E Y ^a   Pearce, E J ^a  

^a Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 5; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNE RESPONSE; LIVER INJURY; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; TOXOPLASMA GONDII; TOXOPLASMOSIS;

ANIMALS; FEMALE; INFLAMMATION MEDIATORS; INTERLEUKIN-12; LIVER; MICE; MICE, MUTANT STRAINS; SCHISTOSOMIASIS MANSONI; SURVIVAL ANALYSIS; SURVIVORS; TH2 CELLS; TOXOPLASMOSIS, ANIMAL;

EID: 0035111755     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.3.1454-1462.2001     Document Type: Article

References (40)

1. Functional diversity of helper T lymphocytes
2. Immunoregulation during toxoplasmosis
3. Evidence of a T helper type 2 activation in human schistosomiasis
4. Murine neutrophil stimulation by Toxoplasma gondii antigen drives high level production of IFN-gamma-independent IL-12
5. Induction of collagen synthesis in cultured human fibroblasts by live Schistosoma mansoni eggs and soluble egg antigens (SEA)
6. Induction of granulomatous and elicitation of cutaneous sensitivity by partially purified SEA of Schistosoma mansoni
7. Nitric oxide and the Th2 response combine to prevent severe hepatic damage during Schistosoma mansoni infection
8. IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasis
9. Role of cytokines in the formation and downregulation of hepatic circumoval granulomas and hepatic fibrosis in Schistosoma mansoni-infected mice
10. T lymphocyte-dependent effector mechanisms of immunity to Toxoplasma gondii
11. Augmentation of the CD8+ T cell response by IFN-gamma in IL-12-deficient mice during Toxoplasma gondii infection
12. Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
13. Galactosamine-induced sensitization to the lethal effects of endotoxin
14. Role of IL-12 in the initiation of cell mediated immunity by Toxoplasma gondii and its regulation by IL-10 and nitric oxide
15. Parasite-induced IL-12 stimulates early IFN-gamma synthesis and resistance during acute infection with Toxoplasma gondii
16. In the absence of endogenous IL-10, mice acutely infected with Toxoplasma gondii succumb to a lethal immune response dependent on CD4+ T cells and accompanied by overproduction of IL-12. IFN-gamma and TNF-alpha
17. Egg deposition is the major stimulus for the production of Th2 cytokines in murine schistosomiasis mansoni
18. The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12
19. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni
20. Lethal toxicity of lipopolysaccharide and tumor necrosis factor in normal and D-galactosamine-treated mice
21. TNF-alpha, nitric oxide and IFN-gamma are all critical for development of necrosis in the small intestine and early mortality in genetically susceptible mice infected perorally with Toxoplasma gondii
22. Association of CD4+ T cell-dependent, interferon-gamma-mediated necrosis of the small intestine with genetic susceptibility of mice to peroral infection with Toxoplasma gondii
23. Toxoplasma gondii and Schistosoma mansoni synergize to promote hepatocyte dysfunction associated with high levels of plasma TNF-alpha and early death in C57BL/6 mice
24. Toxoplasma gondii triggers granulocyte-dependent cytokine-mediated lethal shock in D-galactosamine-sensitized mice
25. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
26. Interleukin-12 can directly induce T-helper 1 responses in interferon-gamma (IFN-gamma) receptor-deficient mice, but requires IFNgamma signalling to downregulate T-helper 2 responses
27. High levels of TNF, soluble TNF receptors, soluble ICAM-1, and IFN-gamma, but low levels of IL-5, are associated with hepatosplenic disease in human schistosomiasis mansoni
28. Hepatic injury and lethal shock in galactosamine-sensitized mice induced by the superantigen staphylococcal enterotoxin B
29. Role of interleukin-10 in regulation of T-cell-dependent and T-cell-independent mechanisms of resistance to Toxoplasma gondii
30. Interleukin-4 and interferon-gamma: The quintessence of a mutual antagonistic relationship
31. Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent
32. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni
33. IL-12 gene-deficient C57BL/6 mice are susceptible to Leishmania donovani but have diminished hepatic immunopathology
34. An IL-12-based vaccine approach for preventing immunopathology in schistosomiasis
35. Interferon-gamma: The major mediator of resistance against Toxoplasma gondii
36. Antibody against interleukin-6 reduces inflammation and numbers of cysts in brains of mice with toxoplasmic encephalitis
37. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
38. Leukocytes of patients with Schistosoma mansoni respond with a Th2 pattern of cytokine production to mitogen or egg antigens but with a Th0 pattern to worm antigens
39. Cytokine regulation of IL-12 receptor beta2 expression: Differential effects on human T and NK cells
40. An IL-12-based vaccination method for preventing fibrosis induced by schistosome infection