Severe schistosomiasis in the absence of interleukin-4 (IL-4) is IL-12 independent

Infection and Immunity

Volumn 69, Issue 1, 2001, Pages 589-592

  Patton, E A ^a   Brunet, L R ^a   La Flamme, A C ^a   Pedras Vasconcelos, J ^a   Kopf, M ^a   Pearce, E J ^a  

^a Department of Molecular Biology and Genetics   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOARCHITECTURE; DISEASE SEVERITY; ENDOTHELIUM CELL; GENE DISRUPTION; GENETIC SUSCEPTIBILITY; IMMUNE RESPONSE; MEDIATOR RELEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS;

ANIMALS; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-4; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE; SCHISTOSOMIASIS MANSONI; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0035168280     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.1.589-592.2001     Document Type: Article

References (21)

1. Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs
2. IL-4 protects against TNF-α mediated cachexia and death during acute schistosomiasis
3. Muscle wasting and dedifferentiation induced by oxidative stress in a murine model of cachexia is prevented by inhibitors of nitric oxide synthesis and antioxidants
4. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response
5. Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agent
6. Is TNF really involved in cachexia?
7. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
8. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni
9. Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile
10. Disruption of the murine IL-4 gene blocks Th2 cytokine responses
11. Cytokines and cachexia
12. Genetically resistant mice lacking interleukin-12 are susceptible to infection with Leishmania major and mount a polarized Th2 cell response
13. IL-12 is not required for induction of type 1 cytokine responses in viral infections
14. Schistosomal egg antigen-responsive CD8 T-cell population in Schistosoma mansoni-infected BALB/c mice
15. Schistosoma mansoni in IL-4 deficient mice
16. Type 1 CD8+ T cell responses during infection with the helminth Schistosoma mansoni
17. Differential effects of IL-12 receptor blockade with IL-12 p40 homodimer on the induction of CD4+ and CD8+ IFN-gamma-producing cells
18. Mice lacking IL-12 develop polarized Th1 cells during viral infection
19. The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of the adult worms
20. Wasting in cancer
21. Schistosoma mansoni eggs induce antigen-responsive CD44-hi T helper 2 cells and IL4-secreting CD44-lo cells. Potential for T helper 2 subset differentiation is evident at the precursor level