메뉴 건너뛰기




Volumn 48, Issue 5, 1998, Pages 459-468

Interleukin-4 and interferon-γ: The quintessence of a mutual antagonistic relationship

Author keywords

[No Author keywords available]

Indexed keywords

FC RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 4; PHOSPHOTRANSFERASE;

EID: 0031731993     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1998.00435.x     Document Type: Review
Times cited : (197)

References (99)
  • 1
    • 33845772515 scopus 로고
    • Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin
    • Wheelock EF. Interferon-like virus-inhibitor induced in human leukocytes by phytohemagglutinin. Science 1965;149:310-1.
    • (1965) Science , vol.149 , pp. 310-311
    • Wheelock, E.F.1
  • 3
    • 0026069531 scopus 로고
    • Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by α and γ interferons
    • Lew DJ, Decker T, Strehlow I, Darnell JE. Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by α and γ interferons. Mol Cell Biol 1991;11: 182-91.
    • (1991) Mol Cell Biol , vol.11 , pp. 182-191
    • Lew, D.J.1    Decker, T.2    Strehlow, I.3    Darnell, J.E.4
  • 4
    • 0026019924 scopus 로고
    • Cytoplasmic activation of GAF, an IFN-γ-regulated DNA-binding factor
    • Decker T, Lew DJ, Mirkovitch J, Darnell JE Jr Cytoplasmic activation of GAF, an IFN-γ-regulated DNA-binding factor. Embo J 1991;10:927-32.
    • (1991) Embo J , vol.10 , pp. 927-932
    • Decker, T.1    Lew, D.J.2    Mirkovitch, J.3    Darnell Jr., J.E.4
  • 5
    • 0028097932 scopus 로고
    • Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN-α and IFN-α, and is likely to autoregulate the p91 gene
    • Pine R, Canova A, Schindler C. Tyrosine phosphorylated p91 binds to a single element in the ISGF2/IRF-1 promoter to mediate induction by IFN-α and IFN-α, and is likely to autoregulate the p91 gene. Embo J 1994;13:158-67.
    • (1994) Embo J , vol.13 , pp. 158-167
    • Pine, R.1    Canova, A.2    Schindler, C.3
  • 6
    • 0027464265 scopus 로고
    • Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription
    • Nelson N, Marks MS, Driggers PH, Ozato K. Interferon consensus sequence-binding protein, a member of the interferon regulatory factor family, suppresses interferon-induced gene transcription. Mol Cell Biol 1993;13:588-99.
    • (1993) Mol Cell Biol , vol.13 , pp. 588-599
    • Nelson, N.1    Marks, M.S.2    Driggers, P.H.3    Ozato, K.4
  • 7
    • 0024380583 scopus 로고
    • Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes
    • Harada H, Fujita T, Miyamoto M et al. Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell 1989; 58:729-39.
    • (1989) Cell , vol.58 , pp. 729-739
    • Harada, H.1    Fujita, T.2    Miyamoto, M.3
  • 8
    • 0029016084 scopus 로고
    • Role of interferons and other cytokines in the regulation of the immune response
    • Belardelli F. Role of interferons and other cytokines in the regulation of the immune response. Apmis 1995;103:161-79.
    • (1995) Apmis , vol.103 , pp. 161-179
    • Belardelli, F.1
  • 9
    • 0028852339 scopus 로고
    • Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication
    • Karupiah G, Harris N, Buller RML. Gamma interferon-induced, nitric oxide-mediated inhibition of vaccinia virus replication. J Virol 1995;69:910-15.
    • (1995) J Virol , vol.69 , pp. 910-915
    • Karupiah, G.1    Harris, N.2    Buller, R.M.L.3
  • 10
    • 0010228473 scopus 로고
    • Requirement of endogenous interteron-γ production for resolution of Listeria monocytogenes infection
    • Buchmeier NA, Schreiber RD. Requirement of endogenous interteron-γ production for resolution of Listeria monocytogenes infection. Proc Natl Acad Sci USA 1985;82:7404-8.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7404-7408
    • Buchmeier, N.A.1    Schreiber, R.D.2
  • 11
    • 0023895411 scopus 로고
    • Interferon-γ: The major mediator of resistance against Toxoplasma gondii
    • Suzuki Y, Orellana MA, Schreiber RD, Remington JS. Interferon-γ: the major mediator of resistance against Toxoplasma gondii. Science 1988;240:516-18.
    • (1988) Science , vol.240 , pp. 516-518
    • Suzuki, Y.1    Orellana, M.A.2    Schreiber, R.D.3    Remington, J.S.4
  • 12
    • 0020528710 scopus 로고
    • Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-γ is the activating lymphokine
    • Murray HW, Rubin BY, Rothermel CD. Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-γ is the activating lymphokine. J Clin Invest 1983;72:1506-10.
    • (1983) J Clin Invest , vol.72 , pp. 1506-1510
    • Murray, H.W.1    Rubin, B.Y.2    Rothermel, C.D.3
  • 13
    • 0029928417 scopus 로고    scopus 로고
    • The expanding universe of T-cell subsets. Th1. Th2 and more
    • Mosmann TR, Sad S. The expanding universe of T-cell subsets. Th1. Th2 and more. Immunol Today 1996;17:138-46.
    • (1996) Immunol Today , vol.17 , pp. 138-146
    • Mosmann, T.R.1    Sad, S.2
  • 14
    • 0031172781 scopus 로고    scopus 로고
    • The Th1/Th2 paradigm
    • Romagnani S. The Th1/Th2 paradigm. Immunol Today 1997; 18:263-6.
    • (1997) Immunol Today , vol.18 , pp. 263-266
    • Romagnani, S.1
  • 15
    • 0020081969 scopus 로고
    • Identification of a T cell-derived B cell growth factor distinct from interleukin-2
    • Howard M, Farrar J, Hilfiker M et al. Identification of a T cell-derived B cell growth factor distinct from interleukin-2. J Exp Med 1982;155:914-23.
    • (1982) J Exp Med , vol.155 , pp. 914-923
    • Howard, M.1    Farrar, J.2    Hilfiker, M.3
  • 16
    • 0025764757 scopus 로고
    • Interleukin-4: A prototypic immunoregulatory lymphokine
    • Paul WE. Interleukin-4: a prototypic immunoregulatory lymphokine. Blood 1991;77:1859-70.
    • (1991) Blood , vol.77 , pp. 1859-1870
    • Paul, W.E.1
  • 17
    • 0030637626 scopus 로고    scopus 로고
    • Interleukin-4: Signalling mechanisms and control of T cell differentiation
    • Paul WE. Interleukin-4: signalling mechanisms and control of T cell differentiation. Ciba Found Symp 1997;204:208-16.
    • (1997) Ciba Found Symp , vol.204 , pp. 208-216
    • Paul, W.E.1
  • 18
    • 0023501915 scopus 로고
    • Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness
    • Kurt Jones EA, Hamberg S, Ohara J et al. Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J Exp Med 1987;166:1774-87.
    • (1987) J Exp Med , vol.166 , pp. 1774-1787
    • Kurt Jones, E.A.1    Hamberg, S.2    Ohara, J.3
  • 19
    • 0028177589 scopus 로고
    • 4pos NK 1 lpos T cells promptly produce interleukin-4 in response to in vivo challenge with anti-CD3
    • Yoshimoto T, Paul WECD. 4pos NK 1 lpos T cells promptly produce interleukin-4 in response to in vivo challenge with anti-CD3. J Exp Med 1994;179:1285-95.
    • (1994) J Exp Med , vol.179 , pp. 1285-1295
    • Yoshimoto, T.1    Paul, W.E.C.D.2
  • 20
    • 0026052501 scopus 로고
    • Production of interleukin-4 and other cytokines following stimulation of mast cell lines and in vivo mast cells/basophils
    • Seder RA, Paul WE, Ben Sasson SZ et al. Production of interleukin-4 and other cytokines following stimulation of mast cell lines and in vivo mast cells/basophils. Int Arch Allergy Appl Immunol 1991; 94:137-40.
    • (1991) Int Arch Allergy Appl Immunol , vol.94 , pp. 137-140
    • Seder, R.A.1    Paul, W.E.2    Ben Sasson, S.Z.3
  • 21
    • 0028962572 scopus 로고
    • The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy hy IL-2, IL-4, IL-7, IL-13 and IL-15
    • Lin J, Migone T, Tsang M et al. The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy hy IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 1995;2:331-9.
    • (1995) Immunity , vol.2 , pp. 331-339
    • Lin, J.1    Migone, T.2    Tsang, M.3
  • 22
    • 0027731604 scopus 로고
    • Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4
    • Kondo M, Takeshita T, Ishii N et al. Sharing of the interleukin-2 (IL-2) receptor γ chain between receptors for IL-2 and IL-4. Science 1993;262:1874-7.
    • (1993) Science , vol.262 , pp. 1874-1877
    • Kondo, M.1    Takeshita, T.2    Ishii, N.3
  • 23
    • 43949160885 scopus 로고
    • Interleukin 4 receptor: Signaling mechanisms
    • Keegan AD, Nelms K, Wang LM et al. Interleukin 4 receptor: signaling mechanisms. Immunol Today 1994;15:423-32.
    • (1994) Immunol Today , vol.15 , pp. 423-432
    • Keegan, A.D.1    Nelms, K.2    Wang, L.M.3
  • 24
    • 0030239633 scopus 로고    scopus 로고
    • IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6
    • Ohmori Y, Smith MF Jr, Hamilton TA. IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6. J Immunol 1996;157:2058-65.
    • (1996) J Immunol , vol.157 , pp. 2058-2065
    • Ohmori, Y.1    Smith Jr., M.F.2    Hamilton, T.A.3
  • 25
    • 0031252357 scopus 로고    scopus 로고
    • Cooperation of binding sites tor STAT6 and NF κB/rel in the IL-4-induced up-regulation of the human IgE germline promoter
    • Messner B, Stutz AM, Albrecht B et al. Cooperation of binding sites tor STAT6 and NF κB/rel in the IL-4-induced up-regulation of the human IgE germline promoter. J Immunol 1997;159:3330-7.
    • (1997) J Immunol , vol.159 , pp. 3330-3337
    • Messner, B.1    Stutz, A.M.2    Albrecht, B.3
  • 26
    • 0029795585 scopus 로고    scopus 로고
    • Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene
    • Kotanides H, Reich NC. Interleukin-4-induced STAT6 recognizes and activates a target site in the promoter of the interleukin-4 receptor gene. J Biol Chem 1996;271:25555-61.
    • (1996) J Biol Chem , vol.271 , pp. 25555-25561
    • Kotanides, H.1    Reich, N.C.2
  • 27
    • 0027141894 scopus 로고
    • Modulation of murine macrophage function by IL-13
    • Doherty TM, Kastelein R, Menon S et al. Modulation of murine macrophage function by IL-13. J Immunol 1993;151:7151-60.
    • (1993) J Immunol , vol.151 , pp. 7151-7160
    • Doherty, T.M.1    Kastelein, R.2    Menon, S.3
  • 28
    • 0027492915 scopus 로고
    • Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation with IL-10 and IFN-γ
    • Waal Malefyt R, Figdor CD, Huijbens R et al. Effects of IL-13 on phenotype, cytokine production, and cytotoxic function of human monocytes. Comparison with IL-4 and modulation with IL-10 and IFN-γ. J Immunol 1993;151:6370-81.
    • (1993) J Immunol , vol.151 , pp. 6370-6381
    • Waal Malefyt, R.1    Figdor, C.D.2    Huijbens, R.3
  • 29
    • 0030805936 scopus 로고    scopus 로고
    • Effect of IL-4 and IL-13 on IFN-γ-induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2
    • Paludan SR, Lovmand J, Ellermann-Eriksen S, Mogensen SC. Effect of IL-4 and IL-13 on IFN-γ-induced production of nitric oxide in mouse macrophages infected with herpes simplex virus type 2. Febs Lett 1997;414:61-4.
    • (1997) Febs Lett , vol.414 , pp. 61-64
    • Paludan, S.R.1    Lovmand, J.2    Ellermann-Eriksen, S.3    Mogensen, S.C.4
  • 30
    • 0029885698 scopus 로고    scopus 로고
    • Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor
    • Ryan JJ, McReynolds LJ, Keegan A et al. Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 1996;4:123-32.
    • (1996) Immunity , vol.4 , pp. 123-132
    • Ryan, J.J.1    McReynolds, L.J.2    Keegan, A.3
  • 31
    • 0030444051 scopus 로고    scopus 로고
    • IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway
    • Zamorano J, Wang HY, Wang LM et al. IL-4 protects cells from apoptosis via the insulin receptor substrate pathway and a second independent signaling pathway. J Immunol 1996;157:4926-34.
    • (1996) J Immunol , vol.157 , pp. 4926-4934
    • Zamorano, J.1    Wang, H.Y.2    Wang, L.M.3
  • 32
    • 15844374279 scopus 로고    scopus 로고
    • Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene
    • Shimoda K, van Deursen J, Sangster MY et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996;380:630-3.
    • (1996) Nature , vol.380 , pp. 630-633
    • Shimoda, K.1    Van Deursen, J.2    Sangster, M.Y.3
  • 33
    • 0031308702 scopus 로고    scopus 로고
    • IL-4-induced STAT6 suppresses IFN-γ-stimulated STAT1-dependent transcription in mouse macrophages
    • Ohmori Y, Hamilton TA. IL-4-induced STAT6 suppresses IFN-γ-stimulated STAT1-dependent transcription in mouse macrophages. J Immunol 1997;159:5474-82.
    • (1997) J Immunol , vol.159 , pp. 5474-5482
    • Ohmori, Y.1    Hamilton, T.A.2
  • 34
    • 0029876629 scopus 로고    scopus 로고
    • Stat6 is required for mediating responses to IL-4 and for development of Th2 cells
    • Kaplan MH, Schindler U, Smiley ST, Grusby MJ. Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity 1996;4:313-19.
    • (1996) Immunity , vol.4 , pp. 313-319
    • Kaplan, M.H.1    Schindler, U.2    Smiley, S.T.3    Grusby, M.J.4
  • 35
    • 0028201726 scopus 로고
    • Acquisition of lymphokine-producing phenotype by CD4+ T cells
    • Seder RA, Paul WE. Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 1994;12:635-73.
    • (1994) Annu Rev Immunol , vol.12 , pp. 635-673
    • Seder, R.A.1    Paul, W.E.2
  • 36
    • 0026500979 scopus 로고
    • IL-4 induces a Th2 response in Leishmania major-infected mice
    • Chatelain R, Varkila K, Coffman RL. IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol 1992;148:1182-7.
    • (1992) J Immunol , vol.148 , pp. 1182-1187
    • Chatelain, R.1    Varkila, K.2    Coffman, R.L.3
  • 37
    • 0026056142 scopus 로고
    • IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis
    • Scott P. IFN-γ modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis. J Immunol 1991;147:3149-55.
    • (1991) J Immunol , vol.147 , pp. 3149-3155
    • Scott, P.1
  • 38
    • 0026507228 scopus 로고
    • Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones
    • Maggi E, Parronchi P, Manetti R et al. Reciprocal regulatory effects of IFN-γ and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992;148:2142-7.
    • (1992) J Immunol , vol.148 , pp. 2142-2147
    • Maggi, E.1    Parronchi, P.2    Manetti, R.3
  • 39
    • 0027409793 scopus 로고
    • Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
    • Manetti R, Parronchi P, Giudizi MG et al. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J Exp Med 1993;177:1199-204.
    • (1993) J Exp Med , vol.177 , pp. 1199-1204
    • Manetti, R.1    Parronchi, P.2    Giudizi, M.G.3
  • 40
    • 0029071483 scopus 로고
    • Developmental commitment to the Th2 lineage by extinction of IL-12 signaling
    • Szaho SJ, Jacobson NG, Dighe AS et al. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Immunity 1995;2:665-75.
    • (1995) Immunity , vol.2 , pp. 665-675
    • Szaho, S.J.1    Jacobson, N.G.2    Dighe, A.S.3
  • 41
    • 0030734114 scopus 로고    scopus 로고
    • Interleukin-12 gene expression in human monocyte-derived macrophages stimulated with Mycobacterium bovis BCG. cytokine regulation and effect of NK cells
    • Matsumoto H, Suzuki K, Tsuyuguchi K et al. Interleukin-12 gene expression in human monocyte-derived macrophages stimulated with Mycobacterium bovis BCG. cytokine regulation and effect of NK cells. Infect Immun 1997;65:4405-10.
    • (1997) Infect Immun , vol.65 , pp. 4405-4410
    • Matsumoto, H.1    Suzuki, K.2    Tsuyuguchi, K.3
  • 42
    • 0030051658 scopus 로고    scopus 로고
    • Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines
    • Skeen MJ, Miller MA, Shinnick TM, Ziegler HK. Regulation of murine macrophage IL-12 production. Activation of macrophages in vivo, restimulation in vitro, and modulation by other cytokines. J Immunol 1996;156:1196-206.
    • (1996) J Immunol , vol.156 , pp. 1196-1206
    • Skeen, M.J.1    Miller, M.A.2    Shinnick, T.M.3    Ziegler, H.K.4
  • 43
    • 8044250881 scopus 로고    scopus 로고
    • Regulation of the interleukin (IL)-12R β 2 subunit expression in developing T helper 1 (Th1) and Th2 cells
    • Szabo SJ, Dighe AS, Gubler U, Murphy KM. Regulation of the interleukin (IL)-12R β 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J Exp Med 1997;185:817-24.
    • (1997) J Exp Med , vol.185 , pp. 817-824
    • Szabo, S.J.1    Dighe, A.S.2    Gubler, U.3    Murphy, K.M.4
  • 44
    • 0031054302 scopus 로고    scopus 로고
    • Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression
    • Gollob JA, Kawasaki H, Ritz J. Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur J Immunol 1997;27:647-52.
    • (1997) Eur J Immunol , vol.27 , pp. 647-652
    • Gollob, J.A.1    Kawasaki, H.2    Ritz, J.3
  • 45
    • 0027422313 scopus 로고
    • Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from α β TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent
    • Macatonia SE, Hsieh CS, Murphy KM, O'Garra A. Dendritic cells and macrophages are required for Th1 development of CD4+ T cells from α β TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int Immunol 1993;5:1119-28.
    • (1993) Int Immunol , vol.5 , pp. 1119-1128
    • Macatonia, S.E.1    Hsieh, C.S.2    Murphy, K.M.3    O'Garra, A.4
  • 46
    • 0029937270 scopus 로고    scopus 로고
    • Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    • Kaplan MH, Sun YL, Hoey T, Grusby MJ. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 1996;382:174-7.
    • (1996) Nature , vol.382 , pp. 174-177
    • Kaplan, M.H.1    Sun, Y.L.2    Hoey, T.3    Grusby, M.J.4
  • 47
    • 0030927197 scopus 로고    scopus 로고
    • T-cell-specific expression of the IL-4 gene is regulated by a silencer element and STAT6
    • Kubo M, Ransom J, Webb D et al. T-cell-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. Embo J 1997;16:4007-20.
    • (1997) Embo J , vol.16 , pp. 4007-4020
    • Kubo, M.1    Ransom, J.2    Webb, D.3
  • 48
    • 0031569126 scopus 로고    scopus 로고
    • Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype
    • Nakamura T, Lee RK, Nam SY et al. Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype. J Immunol 1997;158:2648-53.
    • (1997) J Immunol , vol.158 , pp. 2648-2653
    • Nakamura, T.1    Lee, R.K.2    Nam, S.Y.3
  • 49
    • 0029451748 scopus 로고
    • Reversal of polarized T helper 1 and T helper 2 cell populations in murine leishmaniasis
    • Coffman RL, Correa Oliviera R, Mocci S. Reversal of polarized T helper 1 and T helper 2 cell populations in murine leishmaniasis. Ciba Found Symp 1995;195:20-5.
    • (1995) Ciba Found Symp , vol.195 , pp. 20-25
    • Coffman, R.L.1    Correa Oliviera, R.2    Mocci, S.3
  • 50
    • 0029839059 scopus 로고    scopus 로고
    • Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level
    • Sornasse T, Larenas PV, Davis KA et al. Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level. J Exp Med 1996;184:473-83.
    • (1996) J Exp Med , vol.184 , pp. 473-483
    • Sornasse, T.1    Larenas, P.V.2    Davis, K.A.3
  • 51
    • 15144345094 scopus 로고    scopus 로고
    • IFN-γ suppresses the IL-4-induced IL-4 receptor gene expression via post-transcriptional modulation: MRNa destabilization as a common mechanism of IFN-γ antagonism against IL-4 action
    • Lee C, So EY. IFN-γ suppresses the IL-4-induced IL-4 receptor gene expression via post-transcriptional modulation: mRNA destabilization as a common mechanism of IFN-γ antagonism against IL-4 action. J Interferon Cytokine Res 1997;17:S71.
    • (1997) J Interferon Cytokine Res , vol.17
    • Lee, C.1    So, E.Y.2
  • 53
    • 0026696311 scopus 로고
    • Demethylation of the constant region genes of immunoglobulins reflects the differentiation state of the B cell
    • Burger C, Radbruch A. Demethylation of the constant region genes of immunoglobulins reflects the differentiation state of the B cell. Mol Immunol 1992;29:1105-12.
    • (1992) Mol Immunol , vol.29 , pp. 1105-1112
    • Burger, C.1    Radbruch, A.2
  • 54
    • 0025287114 scopus 로고
    • Interleukin 4 induces changes in the chromatin structure of the γ1 switch region in resting B cells before switch recombination
    • Berton MT, Vitetta ES. Interleukin 4 induces changes in the chromatin structure of the γ1 switch region in resting B cells before switch recombination. J Exp Med 1990;172:375-8.
    • (1990) J Exp Med , vol.172 , pp. 375-378
    • Berton, M.T.1    Vitetta, E.S.2
  • 55
    • 0023197097 scopus 로고
    • Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
    • Snapper CM, Paul WE. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987;236:944-7.
    • (1987) Science , vol.236 , pp. 944-947
    • Snapper, C.M.1    Paul, W.E.2
  • 56
    • 0025361669 scopus 로고
    • IL-4 decreases Fcγ R membrane expression and Fcγ R-mediated cytotoxic activity of human monocytes
    • te Velde AA, Huijbens RJ, de Vries JE, Figdor CG. IL-4 decreases Fcγ R membrane expression and Fcγ R-mediated cytotoxic activity of human monocytes. J Immunol 1990;144:3046-51.
    • (1990) J Immunol , vol.144 , pp. 3046-3051
    • Te Velde, A.A.1    Huijbens, R.J.2    De Vries, J.E.3    Figdor, C.G.4
  • 57
    • 0028980109 scopus 로고
    • An interferon-γ activation sequence mediates the transcriptional regulation of the IgG Fc receptor type IC gene by interferon-γ
    • Paquette RL, Minosa MR, Verma MC et al. An interferon-γ activation sequence mediates the transcriptional regulation of the IgG Fc receptor type IC gene by interferon-γ. Mol Immunol 1995;32:841-51.
    • (1995) Mol Immunol , vol.32 , pp. 841-851
    • Paquette, R.L.1    Minosa, M.R.2    Verma, M.C.3
  • 58
    • 0022625666 scopus 로고
    • A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ
    • Coffman RL, Carty J. A T cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. J Immunol 1986;136: 949-54.
    • (1986) J Immunol , vol.136 , pp. 949-954
    • Coffman, R.L.1    Carty, J.2
  • 59
    • 0027533609 scopus 로고
    • Mechanism of IFN-γ down-regulation of the IL-4-induced CD23/FcRII expression in human B cells: Post-transcriptional modulation by IFN-γ
    • Lee C, Yoon S, Pyon K. Mechanism of IFN-γ down-regulation of the IL-4-induced CD23/FcRII expression in human B cells: post-transcriptional modulation by IFN-γ. Mol Immunol 1993;30:301-7.
    • (1993) Mol Immunol , vol.30 , pp. 301-307
    • Lee, C.1    Yoon, S.2    Pyon, K.3
  • 60
    • 0030929805 scopus 로고    scopus 로고
    • Fc receptor biology
    • Daeron M. Fc receptor biology. Ann Rev Immunol 1997;15:203-34.
    • (1997) Ann Rev Immunol , vol.15 , pp. 203-234
    • Daeron, M.1
  • 62
    • 0022869335 scopus 로고
    • Review: Human leukocyte IgG Fc receptors
    • Anderson CL, Looney RJ. Review: Human leukocyte IgG Fc receptors. Immunol Today 1986;7:264-6.
    • (1986) Immunol Today , vol.7 , pp. 264-266
    • Anderson, C.L.1    Looney, R.J.2
  • 63
    • 0027715015 scopus 로고
    • The human IgE network
    • Sutton BJ, Gould HJ. The human IgE network. Nature 1993;366:421-8.
    • (1993) Nature , vol.366 , pp. 421-428
    • Sutton, B.J.1    Gould, H.J.2
  • 64
    • 0029006331 scopus 로고
    • IL-4 activates a latent DNA-binding factor that binds a shared IFN-γ and IL-4 response element present in the germ-line γ1 Ig promoter
    • Berton MT, Linehan LA. IL-4 activates a latent DNA-binding factor that binds a shared IFN-γ and IL-4 response element present in the germ-line γ1 Ig promoter. J Immunol 1995;154:4513-25.
    • (1995) J Immunol , vol.154 , pp. 4513-4525
    • Berton, M.T.1    Linehan, L.A.2
  • 65
    • 0027173826 scopus 로고
    • Regulation of the expression of human C epsilon germline transcript. Identification of a novel IL-4 responsive element
    • Ichiki T, Takahashi W, Watanabe T. Regulation of the expression of human C epsilon germline transcript. Identification of a novel IL-4 responsive element. J Immunol 1993;150:5408-17.
    • (1993) J Immunol , vol.150 , pp. 5408-5417
    • Ichiki, T.1    Takahashi, W.2    Watanabe, T.3
  • 66
    • 0029034506 scopus 로고
    • The interferon-stimulated response element and a κB site mediate synergistic induction of murine IP-10 gene transcription by IFN-γ and TNF-α
    • Ohmori Y, Hamilton TA. The interferon-stimulated response element and a κB site mediate synergistic induction of murine IP-10 gene transcription by IFN-γ and TNF-α. J Immunol 1995;154:5235-44.
    • (1995) J Immunol , vol.154 , pp. 5235-5244
    • Ohmori, Y.1    Hamilton, T.A.2
  • 67
    • 0026094306 scopus 로고
    • Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: An autoregulatory role of IL-10 produced by monocytes
    • de Waal Malefyt R, Abrams J, Bennett B et al. Interleukin 10 (IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes. J Exp Med 1991;174:1209-20.
    • (1991) J Exp Med , vol.174 , pp. 1209-1220
    • De Waal Malefyt, R.1    Abrams, J.2    Bennett, B.3
  • 68
    • 0025889028 scopus 로고
    • IL-10 inhibits cytokine production by activated macrophages
    • Fiorentino DF, Zlotnik A, Mosmann TR et al. IL-10 inhibits cytokine production by activated macrophages. J Immunol 1991;147:3815-22
    • (1991) J Immunol , vol.147 , pp. 3815-3822
    • Fiorentino, D.F.1    Zlotnik, A.2    Mosmann, T.R.3
  • 69
    • 0026552874 scopus 로고
    • IL-4 suppresses cytokine gene expression induced by IFN-γ and/or IL-2 in murine peritoneal macrophages
    • Gautam S, Tebo JM, Hamilton TA. IL-4 suppresses cytokine gene expression induced by IFN-γ and/or IL-2 in murine peritoneal macrophages. J Immunol 1992;148:1725-30.
    • (1992) J Immunol , vol.148 , pp. 1725-1730
    • Gautam, S.1    Tebo, J.M.2    Hamilton, T.A.3
  • 71
    • 0030453086 scopus 로고    scopus 로고
    • Assembly of the phagocyte NADPH oxidase: Molecular interaction of oxidase proteins
    • DeLeo FR, Quinn MT. Assembly of the phagocyte NADPH oxidase: molecular interaction of oxidase proteins. J Leukoc Biol 1996; 60:677-91.
    • (1996) J Leukoc Biol , vol.60 , pp. 677-691
    • DeLeo, F.R.1    Quinn, M.T.2
  • 72
    • 0027368278 scopus 로고
    • Macrophage nitric oxide synthase gene: Two upstream regions mediate induction by interferon γ and lipopolysaccharide
    • Lowenstein CJ, Alley EW, Raval P et al. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc Natl Acad Sci USA 1993;90: 9730-4.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9730-9734
    • Lowenstein, C.J.1    Alley, E.W.2    Raval, P.3
  • 73
    • 0028348307 scopus 로고
    • Requirement for transcription factor IRF-1 in NOS induction
    • Kamijo R, Harda H, Matsuyama T et al. Requirement for transcription factor IRF-1 in NOS induction. Science 1994;263:1612-15.
    • (1994) Science , vol.263 , pp. 1612-1615
    • Kamijo, R.1    Harda, H.2    Matsuyama, T.3
  • 74
    • 0030587170 scopus 로고    scopus 로고
    • Characterization of three promoter elements and cognate DNA binding protein (s) necessary for IFN-γ induction of gp91-phox transcription
    • Eklund EA, Luo W, Skalnik DG. Characterization of three promoter elements and cognate DNA binding protein (s) necessary for IFN-γ induction of gp91-phox transcription. J Immunol 1996;157:2418-29.
    • (1996) J Immunol , vol.157 , pp. 2418-2429
    • Eklund, E.A.1    Luo, W.2    Skalnik, D.G.3
  • 75
    • 0027980203 scopus 로고
    • Mechanism of suppression of NOS expression by IL-4 in primary mouse macrophages
    • Bogdan C, Vodovotz Y, Paik J et al. Mechanism of suppression of NOS expression by IL-4 in primary mouse macrophages. J Leukoc Biol 1994;55:227-33.
    • (1994) J Leukoc Biol , vol.55 , pp. 227-233
    • Bogdan, C.1    Vodovotz, Y.2    Paik, J.3
  • 76
    • 0028891338 scopus 로고
    • Interleukin-4 suppresses the expression of macrophage NADPH oxidase heavy chain subunit (gp91-phox)
    • Zhou Y, Lin G, Murtaugh MP. Interleukin-4 suppresses the expression of macrophage NADPH oxidase heavy chain subunit (gp91-phox). Biochim Biophys Acta 1995;1265:40-8.
    • (1995) Biochim Biophys Acta , vol.1265 , pp. 40-48
    • Zhou, Y.1    Lin, G.2    Murtaugh, M.P.3
  • 77
    • 0027208743 scopus 로고
    • Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage actication
    • Gazzinelli RT, Eltoum I, Wynn TA, Sher A. Acute cerebral toxoplasmosis is induced by in vivo neutralization of TNF-α and correlates with the down-regulated expression of inducible nitric oxide synthase and other markers of macrophage actication. J Immunol 1993;151:3672-81.
    • (1993) J Immunol , vol.151 , pp. 3672-3681
    • Gazzinelli, R.T.1    Eltoum, I.2    Wynn, T.A.3    Sher, A.4
  • 78
    • 0029994967 scopus 로고    scopus 로고
    • Suppression of superoxide anion production by interleukin-10 is accompanied by a down-regulation of the genes for subunit proteins of NADPH oxidase
    • Kuga S, Otsuka T, Niiro H et al. Suppression of superoxide anion production by interleukin-10 is accompanied by a down-regulation of the genes for subunit proteins of NADPH oxidase. Exp Hematol 1996;24:151-17.
    • (1996) Exp Hematol , vol.24 , pp. 151-217
    • Kuga, S.1    Otsuka, T.2    Niiro, H.3
  • 79
    • 0027203305 scopus 로고
    • Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β
    • Vodovotz Y, Bogdan C, Paik J et al. Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor β. J Exp Med 1993;178:605-13.
    • (1993) J Exp Med , vol.178 , pp. 605-613
    • Vodovotz, Y.1    Bogdan, C.2    Paik, J.3
  • 80
    • 0026579761 scopus 로고
    • IL-4 decreases IFN-γ-induced endothelial ICAM-1 expression by a transcriptional mechanism
    • Renkonen R, Mattila P, Majuri ML et al. IL-4 decreases IFN-γ-induced endothelial ICAM-1 expression by a transcriptional mechanism. Scand J Immunol 1992;35:525-30.
    • (1992) Scand J Immunol , vol.35 , pp. 525-530
    • Renkonen, R.1    Mattila, P.2    Majuri, M.L.3
  • 81
    • 0028073850 scopus 로고
    • Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule I
    • Hou J, Baichwal V, Cao Z. Regulatory elements and transcription factors controlling basal and cytokine-induced expression of the gene encoding intercellular adhesion molecule I. Proc Natl Acad Sci USA 1994;91:11641-5.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11641-11645
    • Hou, J.1    Baichwal, V.2    Cao, Z.3
  • 82
    • 0031046507 scopus 로고    scopus 로고
    • Cell adhesion molecule expression within human glomerular and kidney organ culture
    • Savage CO, Brooks CJ, Adu D et al. Cell adhesion molecule expression within human glomerular and kidney organ culture. J Pathol 1997;181:111-15.
    • (1997) J Pathol , vol.181 , pp. 111-115
    • Savage, C.O.1    Brooks, C.J.2    Adu, D.3
  • 83
    • 0025868774 scopus 로고
    • Regulation of macrophage activation markers by IL-4 and IFN-γ is subpopulation-specilic
    • Molina IJ, Huber BT. Regulation of macrophage activation markers by IL-4 and IFN-γ is subpopulation-specilic. Cell Immunol 1991; 134:241-8.
    • (1991) Cell Immunol , vol.134 , pp. 241-248
    • Molina, I.J.1    Huber, B.T.2
  • 84
    • 0025856458 scopus 로고
    • Regulation of fibronectin receptor (α5β1) mRNA expression in human monocytes and monocyte-derived macrophages by activation/differentiation signals
    • Kohn FR, Klingemann HG. Regulation of fibronectin receptor (α5β1) mRNA expression in human monocytes and monocyte-derived macrophages by activation/differentiation signals. Exp Hematol 1991;19:653-8.
    • (1991) Exp Hematol , vol.19 , pp. 653-658
    • Kohn, F.R.1    Klingemann, H.G.2
  • 85
    • 0028022805 scopus 로고
    • Activation of the Ig germline γ1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site
    • Lundgren M, Larsson C, Femino A et al. Activation of the Ig germline γ1 promoter. Involvement of C/enhancer-binding protein transcription factors and their possible interaction with an NF-IL-4 site. J Immunol 1994;153:2983-95.
    • (1994) J Immunol , vol.153 , pp. 2983-2995
    • Lundgren, M.1    Larsson, C.2    Femino, A.3
  • 86
    • 0028917885 scopus 로고
    • Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: Regulation by NF-IL-4, a C/EBP family member and NF-κB/p50
    • Delphin S, Stavnezer J. Characterization of an interleukin 4 (IL-4) responsive region in the immunoglobulin heavy chain germline epsilon promoter: regulation by NF-IL-4, a C/EBP family member and NF-κB/p50. J Exp Med 1995;181:181-92.
    • (1995) J Exp Med , vol.181 , pp. 181-192
    • Delphin, S.1    Stavnezer, J.2
  • 87
    • 0026762988 scopus 로고
    • IL-4 potently enhances murine macrophage mannose receptor activity: A marker of alternative immunologic macrophage activation
    • Stein M, Keshav S, Harris N, Gordon S. IL-4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation. J Exp Med 1992;176: 287-92.
    • (1992) J Exp Med , vol.176 , pp. 287-292
    • Stein, M.1    Keshav, S.2    Harris, N.3    Gordon, S.4
  • 88
    • 0031278369 scopus 로고    scopus 로고
    • TNF-α and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells
    • Barks JL, McQuillan JJ, Iademarco MF. TNF-α and IL-4 synergistically increase vascular cell adhesion molecule-1 expression in cultured vascular smooth muscle cells. J Immunol 1997;159: 4532-8.
    • (1997) J Immunol , vol.159 , pp. 4532-4538
    • Barks, J.L.1    McQuillan, J.J.2    Iademarco, M.F.3
  • 89
    • 0026099349 scopus 로고
    • Interferon-γ-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates
    • Denis M. Interferon-γ-treated murine macrophages inhibit growth of tubercle bacilli via the generation of reactive nitrogen intermediates. Cell Immunol 1991;132:150-7.
    • (1991) Cell Immunol , vol.132 , pp. 150-157
    • Denis, M.1
  • 90
    • 0028006251 scopus 로고
    • Cytokine-mediated regulation of chronic intestinal helminth infection
    • Else KJ, Finkelman FD, Maliszewski CR, Grencis RK. Cytokine-mediated regulation of chronic intestinal helminth infection. J Exp Med 1994;179:347-51.
    • (1994) J Exp Med , vol.179 , pp. 347-351
    • Else, K.J.1    Finkelman, F.D.2    Maliszewski, C.R.3    Grencis, R.K.4
  • 91
    • 0028925987 scopus 로고
    • Regulation of human T lymphocyte chemotaxis in vitro by T cell-derived cytokines IL-2, IFN-γ, IL-4, IL-10, and IL-13
    • Tan J, Deleuran B, Gesser B et al. Regulation of human T lymphocyte chemotaxis in vitro by T cell-derived cytokines IL-2, IFN-γ, IL-4, IL-10, and IL-13. J Immunol 1995;154:3742-52.
    • (1995) J Immunol , vol.154 , pp. 3742-3752
    • Tan, J.1    Deleuran, B.2    Gesser, B.3
  • 92
    • 0025133545 scopus 로고
    • Interleukin-4 (IL-4) inhibits secretion of IL-1β, tumor necrosis factor α, and IL-6 by human monocytes
    • te Velde AA, Huijbens RJ, Heije K et al. Interleukin-4 (IL-4) inhibits secretion of IL-1β, tumor necrosis factor α, and IL-6 by human monocytes. Blood 1990;76:1392-7.
    • (1990) Blood , vol.76 , pp. 1392-1397
    • Te Velde, A.A.1    Huijbens, R.J.2    Heije, K.3
  • 93
    • 0027436373 scopus 로고
    • Interferon-γ overcomes the glucocorticoid-mediated and the interleukin-4-mediated inhibition of interleukin-1β synthesis in human monocytes
    • Geiger T, Arnold J, Rordorf C et al. Interferon-γ overcomes the glucocorticoid-mediated and the interleukin-4-mediated inhibition of interleukin-1β synthesis in human monocytes. Lymphokine Cytokine Res 1993;12:271-8.
    • (1993) Lymphokine Cytokine Res , vol.12 , pp. 271-278
    • Geiger, T.1    Arnold, J.2    Rordorf, C.3
  • 94
    • 0030974344 scopus 로고    scopus 로고
    • Interleukin-4 and -13 inhibit tumor necrosis tactor-α mRNA translational activation in lipopolysaccharide-induced mouse macrophages
    • Mijatovic T, Kruys V, Caput D et al. Interleukin-4 and -13 inhibit tumor necrosis tactor-α mRNA translational activation in lipopolysaccharide-induced mouse macrophages. J Biol Chem 1997;272: 14394-8.
    • (1997) J Biol Chem , vol.272 , pp. 14394-14398
    • Mijatovic, T.1    Kruys, V.2    Caput, D.3
  • 95
    • 0022508711 scopus 로고
    • Interferon-γ inhibits the action of B cell stimulatory factor (BSF)-1 on resting B cells
    • Rabin EM, Mond JJ, Ohara J, Paul WE. Interferon-γ inhibits the action of B cell stimulatory factor (BSF)-1 on resting B cells. J Immunol 1986;137:1573-6.
    • (1986) J Immunol , vol.137 , pp. 1573-1576
    • Rabin, E.M.1    Mond, J.J.2    Ohara, J.3    Paul, W.E.4
  • 96
    • 0031112505 scopus 로고    scopus 로고
    • TGF-β stimulates but IFN-γ inhibits growth-related activation of locomotion of human B cells
    • Komai Koma M, Wilkinson PC. TGF-β stimulates but IFN-γ inhibits growth-related activation of locomotion of human B cells. J Immunol 1997;158:3125-9.
    • (1997) J Immunol , vol.158 , pp. 3125-3129
    • Komai Koma, M.1    Wilkinson, P.C.2
  • 97
    • 0028077321 scopus 로고
    • IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-β and IL-4, and is inhibited by IFN-γ
    • Schmitt E, Germann T, Goedert S et al. IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-β and IL-4, and is inhibited by IFN-γ. J Immunol 1994;153:3989-96.
    • (1994) J Immunol , vol.153 , pp. 3989-3996
    • Schmitt, E.1    Germann, T.2    Goedert, S.3
  • 98
    • 0027331547 scopus 로고
    • Allergy-associated I epsilon and Ec epsilon receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element
    • Kohler I, Rieber EP. Allergy-associated I epsilon and Ec epsilon receptor II (CD23b) genes activated via binding of an interleukin-4-induced transcription factor to a novel responsive element. Eur J Immunol 1993;23:3066-71.
    • (1993) Eur J Immunol , vol.23 , pp. 3066-3071
    • Kohler, I.1    Rieber, E.P.2
  • 99
    • 0026759824 scopus 로고
    • Enhanced IL-4 production and IL-4 receptor expression in atopic dermatitis and their modulation by interferon-γ
    • Renz H, Jujo K, Bradley KL et al. Enhanced IL-4 production and IL-4 receptor expression in atopic dermatitis and their modulation by interferon-γ. J Invest Dermatol 1992;99:403-8.
    • (1992) J Invest Dermatol , vol.99 , pp. 403-408
    • Renz, H.1    Jujo, K.2    Bradley, K.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.