Cytokine regulation of IL-12 receptor β2 expression: Differential effects on human T and NK cells

European Journal of Immunology

Volumn 30, Issue 5, 2000, Pages 1364-1374

  Wu, Chang You ^a   Gadina, Massimo ^b   Wang, Kening ^a   O'Shea, John ^b   Seder, Robert A ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Cytokine; IFN; IL 12 receptor; NK cell; T cell

Indexed keywords

ALPHA INTERFERON; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 12 RECEPTOR; INTERLEUKIN 2; INTERLEUKIN 4; RECEPTOR SUBTYPE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LYMPHOCYTE CULTURE; NATURAL KILLER CELL; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; HUMANS; KILLER CELLS, NATURAL; LYMPHOCYTE ACTIVATION; MICE; PHOSPHORYLATION; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-12; SIGNAL TRANSDUCTION;

EID: 0034023725     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(200005)30:5<1364::AID-IMMU1364>3.0.CO;2-U     Document Type: Article

References (22)

1. Gately, M. K., Renzetti, L. M., Magram, J., Stern, A. S., Adorini, L., Gubler, U. and Presky, D. H., The interleukin-12/ interleukin-12-receptor system: role in normal and pathologie immune response. Annu. Rev. Immunol. 1998. 16: 495-521.
2. Presky, D. H., Yang, H., Minetti, L. J., Chua, A. O., Nabavi, N., Wu, C.-Y., Gately, M. K. and Gubler, U., A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 1996. 93: 14002-14007.
3. Rogge, L., Barberis-Maino, L., Biffi, M., Passini, N., Presky, D. H., Gubler, U. and Sinigaglia, F, Selective expression of an interleukin-12 receptor component by human T helper 1 cells. J. Exp. Med. 1997. 185: 825-831.
4. Szabo, S., Dighe, A. S., Gubler, U. and Murphy, K. M., Regulation of the interleukin (IL)-12Rß2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 1997. 185:817-824.
5. Rogge, L., Papi, A., Presky, D. H., Biffi, M., Minetti, L. J., Miotto, D., Agostini, C., Semenzato, G., Fabbri, L. M. and Sinigaglia, F., Antibodies to the IL-12 receptor β2 chain mark human Th1 but not Th2 cells in vitro and in vivo. J. Immunol. 1999. 162: 3926-3932.
6. Gollob, J. A., Kawasaki, H. and Ritz, J., Interferon-γ and interleukin-4 regulate T cell interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression. Eur. J. Immunol. 1997. 27: 647-652.
7. Gollob, J. A., Murphy, E. A., Mahajan, S., Schnipper, C. P., Ritz, J. and Frank, D., Altered interleukin-12 responsiveness in Th1 and Th2 cells is associated with the differential activation of STAT5 and STAT1. Blood 1998. 91: 1341-1354.
8. Cho, S. S., Bacon, C. M., Sudarshan, C., Rees, R. C., Finbloom, D., Pine, R. and O'Shea, J. J., Activation of STAT4 by IL-12 and IFN-α. Evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J. Immunol. 1996. 157: 4781-4789.
9. Finkelman, F. D., Svetic, A., Gresser, I., Snapper, C., Holmes, J., Trotta, P. P., Katona, I. M. and Cause, W. C., Regulation by Interferon α of immunoglobulin isotype selection and iymphokine production in mice. J. Exp. Med. 1991. 174: 1179-1188.
10. Brinkmann, V., Geiger, T., Alkan, S. and Heusser, C. H., Interferon α increases the frequency of interferon γ-producing human CD4 T cells. J. Exp. Med. 1993. 178: 1655-1663.
11. Rogge, L., D'Ambrosio, D., Biffi, M., Penna, G., Minetti, L. J., Presky, D. H., Adorini, L. and Sinigaglia, F, The role of STAT4 in species-specific regulation of Th cell development by type I IFNs. J. Immunol. 1998. 161: 6567-6574.
12. Venkataraman, C., Leung, S., Salvekar, A., Mano, H. and Schindlet, U., Repression of IL-4-induced gene expression by IFN-γ requires STAT1 activation. J. Immunol. 1999. 162: 4053-4061.
13. Dickensheets, H. L and Donnelly, R. P., Inhibition of IL-4-inducible gene expression in human monocytes by type I and type II interferons. J. Leukoc. Biol. 1999. 65: 307-312.
14. Losman, J. A., Chen, X. P., Hilton, D. and Rothman, P., SOCS-1 is a potent inhibitor of IL-4 signal transduction. J. Immunol. 1999. 162: 3770-3774.
15. Fehniger, T. A., Shah, M. H., Turner, M. J., VanDeusen, J. B., Whitmen, S. P., Cooper, M. A., Suzuki, K., Wechser, M., Goodsaid, F. and Caligiuri, M. A., Differential cytokine and chemokine gene expression by human NK cells following activation with IL-18 or IL-15 in combination with IL-12: implications for the innate immune response. J. Immunol. 1999. 162: 4511-4520.
16. Cousens, L. P., Orange, J. S., Su, H. C. and Biron, C. A., Interferon-α.β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 1997. 94: 634-639.
17. Cousens, L. P., Peterson, R., Hsu, S., Dorner, A., Altman, J. D., Ahmed, R. and Biron, C. A., Two roads diverged: Interferon u/ß- and interleukin 12-mediated pathways in promoting T cell Interferon-γ responses during viral infection. J. Exp. Med. 1999. 189: 1315-1327.
18. - T cells. J. Exp. Med. 1999. 189: 1355-1360.
19. Xu, D., Chan, W. L., Leung, B. P., Hunter, D., Schulz, K., Carter, R. W., McInnes, I. B., Robinson, J. H. and Liew, F. Y., Selective expression and function of interleukin 18 receptor on T helper (Th) 1 but not Th2 cells. J. Exp. Med. 1998. 188: 1485-1492.
20. Yoshimoto, T., Takeda, K., Tanaka, T., Ohkusu, K., Kashiwamura, C., Okamura, H., Akira, S. and Nakanishi, K., IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol. 1998. 161: 3400-3407.
21. Zhang, M., Gong, J., Presky, D. H., Xue, W. and Barnes, P. F., Expression of the IL-12 receptor β1 and β2 subunits in human tuberculosis. J. Immunol. 1999. 162: 2441-2447.
22. Braun, M. C., He, J., Wu, C.-Y. and Kelsall, B. L., Cholera toxin suppresses interleukin (IL)-12 production and IL-12 receptor β1 and β2 chain expression. J. Exp. Med. 1999. 189: 541-552.