F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat

Molecular and Cellular Biology

Volumn 21, Issue 7, 2001, Pages 2506-2520

  Hsiung, Y G ^a   Chang, H C ^a   Pellequer, J L ^a   La Valle, R ^a   Lanker, S ^a   Wittenberg, C ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CULLIN; F BOX PROTEIN; GENE PRODUCT; LEUCINE; LIGASE; PROTEIN GRR1; PROTEIN SKP1; UBIQUITIN; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; ENZYME SPECIFICITY; HYPERPOLARIZATION; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOTIDE REPEAT; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; PROTEIN TARGETING; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BINDING SITES; CARRIER PROTEINS; CYCLINS; FUNGAL PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN BINDING; PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UBIQUITIN-PROTEIN LIGASES;

EID: 0035106567     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.7.2506-2520.2001     Document Type: Article

References (59)

1. SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box
2. G1 cyclin turnover and nutrient uptake are controlled by a common pathway in yeast
3. Mutational analysis of morphologic differentiation in Saccharomyces cerevisiae
4. CHARMM: A program for macromolecular energy, minimalization, and molecular dynamics calculations
5. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
6. SCF and cullin/ring H2-based ubiquitin ligases
7. The Cdc4/34/53 pathway targets Cdc6p for proteolysis in budding yeast
8. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
9. GRR1 of Saccharomyces cerevisiae is required for glucose repression and encodes a protein with leucine-rich repeats
10. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six base pair restriction sites
11. Induction of pseudohyphal growth by overexpression of PHD1, a Saccharomyces cerevisiae gene related to transcriptional regulators of fungal development
12. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast
13. The ubiquitin system
14. Amino acid signaling in Saccharomyces cerevisiae: A permease-like sensor of external amino acids and F-box protein Grr1p are required for transcriptional induction of the AGP1 gene, which encodes a broad-specificity amino acid permease
15. The acid-labile subunit of the serum insulin-like growth factor-binding protein complexes. Structural determination by molecular modeling and electron microscopy
16. Grr1 complex
17. Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4
18. Cdc34 and the F-box protein Met30 are required for degradation of the Cdk-inhibitory kinase Swe1
19. Structural diversity of leucine-rich repeat proteins
20. The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2
21. Phosphorylation meets ubiquitination: The control of NF-κB activity
22. An essential function of Grr1 for the degradation of Cln2 is to act as a binding core that links Cln2 to Skp1
23. SGT1 encodes an essential component of the yeast kinetochore assembly pathway and a novel subunit of the SCF ubiquitin ligase complex
24. Mechanism of ribonuclease inhibition by ribonuclease inhibitor protein based on the crystal structure of its complex with ribonuclease A
25. Proteins with leucine-rich repeats
26. A structural basis of the interactions between leucine-rich repeats and protein ligands
27. Symmetric cell division in pseudohyphae of the yeast Saccharomyces cerevisiae
28. Modification of yeast Cdc53p by the ubiquitin-related protein rub1p affects function of the SCFCdc4 complex
29. Rapid degradation of the G1 cyclin, Cln2, induced by CDK-dependent phosphorylation
30. Grr1 of Saccharomyces cerevisiae is connected to the ubiquitin proteolysis machinery through Skp1: Coupling glucose sensing to gene expression and the cell cycle
31. Saccharomyces cerevisiae G1 cyclins are differentially involved in invasive and pseudohyphal growth independent of the filamentation mitogen-activated protein kinase pathway
32. Interaction between ubiquitin-protein ligase SCF, SKP2 and E2F-1 underlies the regulation of E2F-1 degradation
33. StalView: A visual protein crystallographic software system for X11/XView
34. Identification of genes controlling growth polarity in the budding yeast Saccharomyces cerevisiae: A possible role of N-glycosylation and involvement of the exocyst complex
35. Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication
36. Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast
37. Function and regulation of yeast hexose transporters
38. Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose
39. Rgt1p of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription
40. Glucose uptake and metabolism in grr1/cat80 mutants of Saccharomyces cerevisiae
41. Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box protein complexes that regulate cell division and methionine biosynthesis in yeast
42. βTrCP-dependent ubiquitination of IκBα
43. An essential G1 function for cyclin-like proteins in yeast
44. Met30 complex
45. Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex
46. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34
47. F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
48. Grr1 and Rbx1
49. Metabolism of sulfur amino acids in Saccharomyces cerevisiae
50. Skp2 complex through phosphorylated Thr187 in p27
51. Altered regulatory responses to glucose are associated with a glucose transport defect in grr1 mutants of Saccharomyces cerevisiae
52. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities
53. Cdc53 targets phosphorylated G1 cyclins for degradation by the ubiquitin proteolytic pathway
54. Subcellular localization of a protein kinase required for cell cycle initiation in Saccharomyces cerevisiae: Evidence for an association between the CDC28 gene product and the insoluble cytoplasmic matrix
55. CDC28 protein kinase
56. Reversible pseudohyphal growth in haploid Saccharomyces cerevisiae is an aerobic process
57. Ubiquitination and degradation of the substrate recognition subunits of SCF ubiquitin-protein ligases