Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo

Development

Volumn 128, Issue 5, 2001, Pages 753-765

  Perea Gomez, A ^a   Lawson, K A ^a   Rhinn, M ^a   Zakin, L ^a   Brulet P ^a   Mazan, S ^a   Ang, S L ^a  

^a INSERM   (France)

Author keywords

Anterior posterior; Forebrain; Lineage; Mesoderm; Mouse; Otx2; Visceral endoderm

Indexed keywords

BIOCHEMICAL MARKER; BONE MORPHOGENETIC PROTEIN 4; HOMEODOMAIN PROTEIN; LEFTY 1 PROTEIN; MDKK 1 PROTEIN; PROTEIN NODAL; TRANSCRIPTION FACTOR OTX2; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOLOGY; ECTODERM; EMBRYO; EMBRYOLOGY; ENDODERM; FOREBRAIN; GASTRULATION; GENE FUNCTION; GENETIC ANALYSIS; HOMEOBOX; MOLECULAR BIOLOGY; MOLECULE; MORPHOGENESIS; MOUSE; MUTANT; NEUROECTODERM; NONHUMAN; PRIMITIVE STREAK; PRIORITY JOURNAL; PROTEIN SECRETION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; VISCERA;

ANIMALS; BIOLOGICAL MARKERS; BODY PATTERNING; CELL LINEAGE; CELL MOVEMENT; CLONE CELLS; DNA; ECTODERM; EMBRYONIC AND FETAL DEVELOPMENT; ENDODERM; GASTRULA; GENOTYPE; HOMEODOMAIN PROTEINS; HORSERADISH PEROXIDASE; IN SITU HYBRIDIZATION; MICE; MICE, MUTANT STRAINS; NERVE TISSUE PROTEINS; NERVOUS SYSTEM; OTX TRANSCRIPTION FACTORS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; STEM CELLS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; VERTEBRATA;

EID: 0035092909     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (77)

1. -/- mutants due to a defective anterior neuroectoderm specification during gastrulation
2. Visceral endoderm-restricted translation of Otx1 mediates recovery of Otx2 requirements for specification of anterior neural plate and normal gastrulation
3. HNF-3 beta is essential for node and notochord formation in mouse development
4. Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants
5. A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain
6. Brachyury is a target gene of the Wnt/beta-catenin signaling pathway
7. Establishment of anterior-posterior polarity in avian embryos
8. Clonal analysis of cell lineages
9. Axis development and early asymmetry in mammals
10. Expression of Otx homeodomain proteins induces cell aggregation in developing zebrafish embryos
11. Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula
12. Cerberus-like is a secreted BMP and nodal antagonist not essential for mouse development
13. Murine cerberus homologue mCer-1: A candidate anterior patterning molecule
14. Distinct roles for visceral endoderm during embryonic mouse development
15. The morphogenetic role of midline mesendoderm and ectoderm in the development of the forebrain and the midbrain of the mouse embryo
16. Detection of messenger RNA by in situ hybridization to postimplantation embryo whole mounts
17. A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse
18. Tissue-specific requirements for the proprotein convertase furin/SPC1 during embryonic turning and heart looping
19. BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo
20. The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo
21. Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo
22. Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope
23. The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis
24. Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis
25. Reconciling different models of forebrain induction and patterning: A dual role for the hypoblast
26. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
27. Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors
28. The EGF-CFC protein one-eyed pinhead is essential for nodal signaling
29. Visceral endoderm mediates forebrain development by suppressing posteriorizing signals
30. Detection of ebaf, a novel human gene of the transforming growth factor beta superfamily association of gene expression with endometrial bleeding
31. Simplified mammalian DNA isolation procedure
32. Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer
33. Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse
34. Clonal analysis of epiblast fate during germ layer formation in the mouse embryo
35. Clonal analysis of cell fate during gastrulation and early neurulation in the mouse
36. Requirement for Wnt3 in vertebrate axis formation
37. The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation
38. Mouse Otx2 functions in the formation and patterning of rostral head
39. Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: Their distinct expression domains chromosomal linkage and direct neuralizing activity in Xenopus embryos
40. Lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal
41. Mouse Lefty2 and zebrafish antivin are feedback inhibitors of node signaling during vertebrate gastrulation
42. Bm encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis
43. A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung
44. Calponin modulates the exclusion of Otx-expressing cells from convergence extension movements
45. Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements
46. Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily
47. A mouse cerberus/Dan-related gene family
48. HNF3beta and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo
49. Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo
50. Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification
51. Cell autonomous and non-cell autonomous functions of Otx2 in patterning the rostral brain
52. Eomesodermin is required for mouse trophoblast development and mesoderm formation
53. MesP1: A novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation
54. Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2
55. Nodal signalling in vertebrate development
56. Expression of the mouse cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somitogenesis
57. Lim1 is required in both primitive streak-derived tissues and visceral endoderm for head formation in the mouse
58. The cerberus-related gene, Cerr1, is not essential for mouse head formation
59. Isolation of novel cDNAsby subtractions between the anterior mesendoderm of single mouse gastrula stage embryos
60. Nested expression domains of four homeobox genes in developing rostral brain
61. The mouse Cer1 (Cerberus related or homologue) gene is not required for anterior pattern formation
62. Targeted insertion of a lacZ reporter gene into the mouse Cer1 locus reveals complex and dynamic expression during embryogenesis
63. Experimental specification of cell sorting, tissue spreading, and specific spatial patterning by quantitative differences in cadherin expression
64. Initiation of neural induction by FGF signalling before gastrulation
65. Targeted disruption of Fgf8 causes failure of cell migration in the gastrulating mouse embryo
66. Lineage and functional analyses of the mouse organizer
67. Anterior patterning by synergistic activity of the early gastrula organizer and the anterior germ layer tissues of the mouse embryo
68. Antivin, a novel and divergent member of the TGFβ superfamily, negatively regulates mesoderm induction
69. Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo
70. Hex: A homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors
71. Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation
72. Development of chick axial mesoderm: Specification of prechordal mesoderm by anterior endoderm-derived TGFbeta family signalling
73. Polarity of the mouse embryo is anticipated before implantation
74. Expression pattern of the mouse T gene and its role in mesoderm formation
75. Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse
76. T (Brachyury) is a direct target of Wnt3a during paraxial mesoderm specification
77. Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation