HNF3β and Lim1 interact in the visceral endoderm to regulate primitive streak formation and anterior-posterior polarity in the mouse embryo

Development

Volumn 126, Issue 20, 1999, Pages 4499-4511

  Perea Gómez, Aitana ^a   Shawlot, William ^b,d   Sasaki, Hiroshi ^c   Behringer, Richard R ^b   Ang, Siew Lan ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITY OF TEXAS   (United States)

^c OSAKA UNIVERSITY   (Japan)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Anteroposterior axis; HNF3 ; Lim1; Mesoderm; Patterning; Visceral endoderm

Indexed keywords

ANTERIOR POSTERIOR AXIS; ARTICLE; CHIMERA; EMBRYO; EMBRYO PATTERN FORMATION; ENDODERM; GASTRULA; GENE ACTIVITY; GENE CONTROL; MOUSE; MUTANT; NONHUMAN; PRIMITIVE STREAK; PRIORITY JOURNAL; ANIMAL; CYTOLOGY; ECTODERM; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HOMOZYGOTE; MALE; MESODERM; MORPHOGENESIS; MOUSE MUTANT; MUTATION; PHENOTYPE; PREGNANCY;

DNA BINDING PROTEIN; FOXA2 PROTEIN, MOUSE; HEPATOCYTE NUCLEAR FACTOR 3BETA; HOMEODOMAIN PROTEIN; LHX1 PROTEIN, MOUSE; NUCLEAR PROTEIN; TRANSCRIPTION FACTOR;

ANIMALS; BODY PATTERNING; CHIMERA; DNA-BINDING PROTEINS; ECTODERM; ENDODERM; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HOMEODOMAIN PROTEINS; HOMOZYGOTE; MALE; MESODERM; MICE; MICE, MUTANT STRAINS; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; PREGNANCY; TRANSCRIPTION FACTORS;

EID: 0032589308     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (59)

1. Ang, S. L., Rossant, J. (1994). HNF-3beta is essential for node and notochord formation in mouse development. Cell 78, 561-574.
2. Ang, S. L., Conlon, R. A., Jin, O. and Rossant, J. (1994). Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. Development 120, 2979-2989.
3. Barnes, J. D., Crosby, J. L., Jones, C. M., Wright, C. V. and Hogan, B. L. (1994). Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. Dev. Biol. 161, 168-178.
4. Beddington, R. S. P., Morgenstein, J., Land, H. and Hogan, A. (1989). An situ transgenic enzyme marker for the midgestation mouse embryo and the visualization of the inner cell mass clones during early organogenesis. Development 106, 37-46.
5. Beddington, R. S. P. (1994). Induction of a second neural axis by the mouse node. Development 120, 613-620.
6. Beddington, R. S. and Robertson, E. J. (1998). Anterior patterning in mouse. Trends Genet. 14, 277-284.
7. Beddington, R. S. and Robertson, E. J. (1999). Axis development and early asymmetry in mammals. Cell 96, 195-209.
8. Belo, J. A., Bouwmeester, T., Leyns, L., Kertesz, N., Gallo, M., Follettie, M. and De Robertis, E. M. (1997). Cerberus-like is a secreted factor with neutralizing activity expressed in the anterior primitive endoderm of the mouse gastrula. Mech. Dev. 68, 45-57.
9. Bettenhausen, B., Hrabe de Angelis, M., Simon, D., Guenet, J. L. and Gossler, A. (1995). Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development 121, 2407-2418.
10. Biben, C., Stanley, E., Fabri, L., Kotecha, S., Rhinn, M., Drinkwater, C., Lah, M., Wang, C. C., Nash, A., Hilton, D., Ang, S. L., Mohun, T. and Harvey, R. P. (1998). Murine cerberus homologue mCer-1: a candidate anterior patterning molecule. Dev. Biol. 194, 135-151.
11. Blum, M., Gaunt, S. J., Cho, K. W., Steinbeisser, H., Blumberg, B., Bittner, D. and De Robertis, E. M. (1992). Gastrulation in the mouse: the role of the homeobox gene goosecoid. Cell 69, 1097-1106.
12. Bouwmeester, T., Kim, S., Sasai, Y., Lu, B. and De Robertis, E. M. (1996) Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer. Nature 382, 595-601.
13. Chapman, D. L., Agulnik, I., Hancock, S., Silver, L. M. and Papaioannou, V. E. (1996). Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation at gastrulation. Dev. Biol. 180, 534-542.
14. Collignon, J., Sockanathan, S., Hacker, A., Cohen-Tannoudji, M., Norris, D., Rastan, S., Stevanovic, M., Goodfellow, P. N. and Lovell-Badge, R. (1996). A comparison of properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2. Development 122, 509-520.
15. Conlon, R. A. and Herrmann, B. G. (1993). Detection of messenger RNA by in situ hybridization to postimplantation embryo whole mounts. Methods Enzymol. 225, 373-383.
16. Crossley, P. H. and Martin, G. R. (1995). The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development 121, 439-451.
17. Davis, C. A., Holmyard, D. P., Millen, K. J. and Joyner, A. L. (1991). Examining pattern formation in mouse, chicken and frog embryos with an En-specific antiserum. Development 111, 287-298.
18. Deng, C. X., Wynshaw-Boris, A., Shen, M. M., Daugherty, C., Ornitz, D. M. and Leder, P. (1994). Murine FGFR-1 is required for early postimplantation growth and axial organization. Genes Dev. 8, 3045-3057.
19. Downs, K. M. and Davies, T. (1993). Staging of gastrulating mouse embryos by morphological landmarks in the dissecting microscope. Development 118, 1255-1266.
20. Dufort, D., Schwartz, L., Harpal, K. and Rossant, J. (1998). The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development 125, 3015-3025.
21. Feldman, B., Gates, M. A., Egan, E. S., Dougan, S. T., Rennebeck, G., Sirotkin, H. I., Schier, A. F. and Talbot, W. S. (1998). Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature 395, 181-185.
22. Filosa, S., Rivera-Perez, J. A., Perea-Gomez, A., Gansmuller, A., Sasaki, H., Behringer, R. R. and Ang, S. L. (1997). Goosecoid and HNF-3beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development 124, 2843-2854.
23. Gradwohl, G., Fode, C. and Guillemot, F. (1996). Restricted expression of a novel bHLH atonal-related protein to undifferentiated neural progenitors. Dev. Biol. 180, 227-241.
24. Hogan, B., Beddington, R., Constantini, F. and Lacy, E. (1994). Manipulating the Mouse Embryo: A Laboratory Manual. New York: Cold Spring Harbor.
25. Howell, M. and Hill, C. S. (1997). XSmad2 directly activates the activin-inducible, dorsal mesoderm gene XFKH1 in Xenopus embryos. EMBO J. 16, 7411-7421.
26. Hsu, D. R., Economides. A. N., Wang, X., Eimon, P. M. and Harland, R. M. ( 1998). The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activities. Mol Cell. 1, 673-683.
27. Laird, P. W., Zijderveld, A., Linders, K., Rudnicki, M. A., Jaenisch, R. and Berns, A. (1991). Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19, 4293.
28. Lawson, K. A., Meneses, J. J. and Pedersen, R. A. (1991). Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-911.
29. Lemaire, P. and Kodjabachian, L. (1996). The vertebrate organizer: structure and molecules. Trends Genet. 12, 525-531.
30. Lin, T. P., Labosky, P. A., Grabel, L. B., Kozak, C. A., Pitman, J. L., Kleeman, J. and MacLeod, C. L. (1994). The Pem homeobox gene is X- linked and exclusively expressed in extraembryonic tissues during early murine development. Dev. Biol 166, 170-179.
31. Meno, C., Saijoh, Y., Fuji, H., Ikeda, M., Yokoyama, T., Yokoyama, M., Toyoda, Y. and Hamada, H. (1996). Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. Nature 381, 151-155.
32. Meno, C, Ito, Y., Saijoh, Y., Matsuda, Y., Tashiro, K., Kuhara, S. and Hamada, H. (1997). Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells 2, 513-524.
33. Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H. and Hamada, H. (1998). lefty-1 is required for left-right determination as a regulator of lefty-2 and Nodal. Cell 94, 287-297.
34. Moens, C. B., Auerbach, A. B., Conlon, R. A., Joyner, A. L. and Rossant, J. A. (1992). Targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. Genes Dev. 6, 691-704.
35. Oulad-Abdelghani, M., Chazaud, C., Bouillet, P., Mattei, M. G., Dolle, P. and Chambon, P. (1998). Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily. Int J Dev Biol. 42, 23-32.
36. Pearce, J. J., Penny, G. and Rossant, J. (1999). A mouse cerberus/Dan-related gene family. Dev. Biol. 209, 98-110.
37. Piccolo, S., Agius, E., Leyns, L., Bhattacharyya, S., Grunz, H., Bouwmeester, T. and De Robertis, E. M. (1999). The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals. Nature 397, 707-710.
38. Rebbert, M. L. and Dawid, I. B. (1997). Transcriptional regulation of the Xlim-1 gene by activin is mediated by an element in intron I. Proc. Natl Acad Sci. USA. 94, 9717-9722.
39. Rhinn, M., Dierich, A., Shawlot, W., Behringer, R. R., Le Meur, M. and Ang, S. L. (1998). Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification. Development 125, 845-856.
40. Rivera-Perez, J. A., Mallo, M., Gendron-Maguire, M., Gridley, T. and Behringer, R. R. (1995). Goosecoid is not an essential component of the mouse gastrula organizer but is required for craniofacial and rib development. Development 121, 3005-3012.
41. Rosner, M. H., Vigano, M. A., Ozato, K., Timmons, P. M., Poirier, F., Rigby, P. W. and Staudt, L. M. (1990). A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature 345, 686-692.
42. Saga, Y., Hata, N., Kobayashi, S., Magnuson, T., Seldin, M. F. andTaketo, M. M. (1996). MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. Development 122, 2769-2778.
43. Shawlot, W. and Behringer, R. R. (1995). Requirement for Lim1 in head-organizer function. Nature 374, 425-430.
44. Simeone, A. (1998). Otx1 and Otx2 in the development and evolution of the mammalian brain. EMBO J. 17, 6790-6798.
45. Tam, P. P. and Behringer, R. R. (1997). Mouse gastrulation: the formation of a mammalian body plan. Mech. Dev. 68, 3-25.
46. Thisse, C. and Thisse, B. (1999). Antivin, a novel and divergent member of the TGFbeta superfamily, negatively regulates mesoderm induction. Development 126, 229-240.
47. Thomas, P. and Beddington, R. S. P. (1996). Anterior primitive endoderm may be responsible for patterning the anterior neural plate in the mouse embryo. Curr. Biol. 6, 1487-1496.
48. Thomas, P. Q., Brown, A. and Beddington, R. S. (1998). Hex: a homeobox gene revealing peri-implantation asymmetry in the mouse embryo and an early transient marker of endothelial cell precursors. Development 125, 85-94.
49. Toyama, R., O'Connell, M. L., Wright, C. V., Kuehn, M. R. and Dawid, I. B. (1995). Nodal induces ectopic goosecoid and lim I expression and axis duplication in zebrafish. Development 121, 383-391.
50. Varlet, I., Collignon, J., Robertson, E. J. (1997). Nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development 124, 1033-1044.
51. Waldrip, W. R., Bikoff, E. K., Hoodless, P. A., Wrana, J. L. and Robertson, E. J. (1998). Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92, 797-808.
52. Weinstein, D. C., Ruiz i Altaba, A., Chen, W. S., Hoodless, P., Prezioso, V. R., Jessell, T.M. and Darnell, J. E. ( 1994). The winged-helix transcription factor HNF-3beta is required for notochord development in the mouse embryo. Cell 78, 575-588.
53. Wilkinson, D. G., Bhatt, S. and McMahon, A. P. (1989). Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development. Development 105, 131-136.
54. Wilkinson, D. G., Bhatt, S. and Herrmann, B. G. (1990). Expression pattern of the mouse T gene and its role in mesoderm formation. Nature 343, 657-659.
55. Winnier, G., Blessing, M., Labosky, P. A. and Hogan, B. L. (1995). Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. Genes Dev. 9, 2105-2116.
56. Wolf, C., Thisse, C., Stoetzel, C., Thisse, B., Gerlinger, P. and Perrin-Schmitt, F. (1991). The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genes. Dev. Biol. 143, 363-373.
57. Yamada, G., Mansouri, A., Torres, M., Stuart, E. T., Blum, M., Schultz, M., De Robertis, E. M. and Gruss, P. (1995). Targeted mutation of the murine goosecoid gene results in craniofacial defects and neonatal death. Development 121, 2917-2922.
58. Yamaguchi, T. P., Dumont, D. J., Conlon, R. A., Breitman, M. L. and Rossant, J. (1993). flk-1, an flt-related receptor tyrosine kinase is an early marker for endothelial cell precursors. Development 118, 489-498.
59. Yamaguchi, T. P., Harpal, K., Henkemeyer, M. and Rossant, J. (1994) fgfr-1 is required for embryonic growth and mesodermal patterning during mouse gastrulation. Genes Dev. 8, 3032-3044.