The impact of phospholipid transfer protein (PLTP) on HDL metabolism

Atherosclerosis

Volumn 155, Issue 2, 2001, Pages 269-281

  Huuskonen, Jarkko ^a   Olkkonen, Vesa M ^a   Jauhiainen, Matti ^a   Ehnholm, Christian ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

Author keywords

Atherosclerosis; HDL; Lipoprotein metabolism; Phospholipid transfer; PLTP; Reverse cholesterol transport

Indexed keywords

ALPHA TOCOPHEROL; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEIN; HIGH DENSITY LIPOPROTEIN; LIPOPOLYSACCHARIDE; PHOSPHOLIPID TRANSFER PROTEIN;

CHOLESTEROL TRANSPORT; CORONARY ARTERY DISEASE; DYSLIPIDEMIA; HUMAN; LIPID COMPOSITION; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; NONHUMAN; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; REGULATORY MECHANISM; REVIEW;

ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CHOLESTEROL; CHOLESTEROL ESTER TRANSFER PROTEINS; DIABETES MELLITUS, TYPE 2; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GLYCOPROTEINS; HUMANS; HYPERLIPIDEMIAS; LIPOPOLYSACCHARIDES; LIPOPROTEINS, HDL; MALE; MEMBRANE PROTEINS; MODELS, MOLECULAR; OBESITY; PHOSPHOLIPID TRANSFER PROTEINS; PHOSPHOLIPIDS; PROTEIN CONFORMATION; VERTEBRATES; VITAMIN E;

EID: 0035089679     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(01)00447-6     Document Type: Review

References (124)

1. Separation of a plasma phospholipid transfer protein from cholesterol ester/phospholipid exchange protein
2. Molecular and macromolecular specificity of human plasma phospholipid transfer protein
3. Changes in the size and density of human high-density lipoproteins promoted by a plasma-conversion factor
4. High density lipoprotein conversion mediated by human plasma phospholipid transfer protein
5. Human plasma phospholipid transfer protein causes high density lipoprotein conversion
6. High-density lipoprotein - The clinical implications of recent studies
7. The plasma lecithin:cholesterol acyltransferase reaction
8. Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein
9. Phospholipid transfer protein mediated conversion of high density lipoproteins generates prebeta 1-HDL
10. Human plasma phospholipid transfer protein increases the antiatherogenic potential of high density lipoproteins in transgenic mice
11. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels
12. Facilitation of phosphatidylcholine transfer into high density lipoproteins by an apolipoprotein in the density 1.20-1.26 g/ml fraction of plasma
13. Isolation and characterization of a phospholipid transfer protein (LTP-II) from human plasma
14. Plasma phospholipid transfer protein enhances transfer and exchange of phospholipids between very low density lipoproteins and high density lipoproteins during lipolysis
15. Complete cDNA encoding human phospholipid transfer protein from human endothelial cells
16. Organisation of human phospholipid transfer protein gene
17. Localization of the human phospholipid transfer protein gene to chromosome 20q12-q13.1
18. Similar organization of the lipopolysaccharide-binding protein (LBP) and phospholipid transfer protein (PLTP) genes suggests a common gene family of lipid-binding proteins
19. The genomic organization of the genes for human lipopolysaccharide binding protein (LBP) and bactericidal permeability increasing protein (BPI) is highly conserved
20. Functional expression of human and mouse plasma phospholipid transfer protein: Effect of recombinant and plasma PLTP on HDL subspecies
21. Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet
22. Functional characterization of the promoter region of the human phospholipid transfer protein gene
23. DNA sequences essential for transcription of human phospholipid transfer protein gene in HepG2 cells
24. DNA sequences responsible for reduced promoter activity of human phospholipid transfer protein by fibrate
25. Effect of gemfibrozil on the regulation of HDL subfractions in hypertriglyceridaemic patients
26. Molecular cloning and functional expression of cDNA encoding the pig plasma phospholipid transfer protein
27. Relationship between phospholipid transfer protein activity and HDL level and size among inbred mouse strains
28. Plasma activities of lecithin:cholesterol acyltransferase, lipid transfer proteins and post-heparin lipases in inbred strains of rabbits hypo- or hyper-responsive to dietary cholesterol
29. Expression of plasma phospholipid transfer protein mRNA in normal and emphysematous lungs and regulation by hypoxia
30. Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution
31. Structure and phospholipid transfer activity of human PLTP: Analysis by molecular modeling and site-directed mutagenesis
32. The implications of the structure of the bactericidal/permeability-increasing protein on the lipid-transfer function of the cholesteryl ester transfer protein
33. The BPI/LBP family of proteins: A structural analysis of conserved regions
34. Biosynthesis and secretion of human plasma phospholipid transfer protein
35. Role of cysteine residues in human plasma phospholipid transfer protein
36. Oxidative modification of HDL3 in vitro and its effect on PLTP-mediated phospholipid transfer
37. Measurement and prediction of the rates of spontaneous transfer of phospholipids between plasma lipoproteins
38. Acyl chain and headgroup specificity of human plasma phospholipid transfer protein
39. Influence of the electrostatic charge of lipoprotein particles on the activity of the human plasma phospholipid transfer protein
40. Determination of the acyl chain specificity of the bovine liver phosphatidylcholine transfer protein. Application of pyrene-labeled phosphatidylcholine species
41. Properties of the binding sites for the sn-1 and sn-2 acyl chains on the phosphatidylinositol transfer protein from bovine brain
42. Phospholipid transfer proteins
43. Net transfer of phospholipid by the nonspecific phospholipid transfer proteins from bovine liver
44. Transfer of cholesterol and oxysterol derivatives by the nonspecific lipid transfer protein (sterol carrier protein 2): A study on its mode of action
45. Phospholipid binding and transfer by the nonspecific lipid-transfer protein (sterol carrier protein 2)
46. Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV -rich lamellar lipoproteins
47. CETP and PLTP have non-overlapping functions in vivo
48. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1
49. Transport of lipids from Golgi to plasma membrane is defective in Tangier disease patients and Abc1-deficient mice
50. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease
51. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
52. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
53. Plasma phospholipid mass transfer rate: Relationship to plasma phospholipid and cholesteryl ester transfer activities and lipid parameters
54. Plasma enzymes and transfer proteins in cholesterol metabolism
55. Lipopolysaccharide binding protein and soluble CD14 catalyze exchange of phospholipids
56. Comparative study of phospholipid transfer activities mediated by cholesteryl ester transfer protein and phospholipid transfer protein
57. Different locations of cholesteryl ester transfer protein and phospholipid transfer protein activities in plasma
58. Phospholipid and cholesteryl ester transfer activities in plasma from 14 vertebrate species. Relation to atherogenesis susceptibility
59. Pig plasma phospholipid transfer protein facilitates HDL interconversion
60. Transformation of high density lipoprotein 2 particles by hepatic lipase and phospholipid transfer protein
61. Phospholipid transfer protein can transform reconstituted discoidal HDL into vesicular structures
62. The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: Evidence for particle fusion
63. Remodeling of HDL by phospholipid transfer protein: Demonstration of particle fusion by 1H NMR spectroscopy
64. ApoA-II/apoA-I molar ratio in the HDL particle influences phospholipid transfer protein-mediated HDL interconversion
65. Triglyceride-enrichment of high density lipoproteins enhances their remodelling by phospholipid transfer protein
66. Acute-phase HDL in phospholipid transfer protein (PLTP) -mediated HDL conversion
67. Phospholipid transfer is a prerequisite for PLTP-mediated HDL conversion
68. Influence of triglyceride enrichment on the remodelling of high density lipoproteins by PLTP
69. The influence of cholesteryl ester transfer protein on the composition, size, and structure of spherical, reconstituted high density lipoproteins
70. Evidence that cholesteryl ester transfer protein-mediated reductions in reconstituted high density lipoprotein size involve particle fusion
71. Opposite effects of cholesteryl ester transfer protein and phospholipid transfer protein on the size distribution of plasma high density lipoproteins. Physiological relevance in alcoholic patients
72. Plasma factors affecting the in vitro conversion of high-density lipoproteins labeled with a non-transferable marker
73. Plasma phospholipid transfer protein. Adenovirus-mediated overexpression in mice leads to decreased plasma high density lipoprotein (HDL) and enhanced hepatic uptake of phospholipids and cholesteryl esters from HDL
74. Adenovirus mediated overexpression of human phospholipid transfer protein alters plasma HDL levels in mice
75. Dynamic changes in mouse lipoproteins induced by transiently expressed human phospholipid transfer protein (PLTP): Importance of PLTP in prebeta-HDL generation
76. Transgenic mice expressing human phospholipid transfer protein have increased HDL/non-HDL cholesterol ratio
77. Increased prebeta-high density lipoprotein, apolipoprotein AI, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein AI transgenes
78. Role of phospholipid transfer protein in high-density lipoprotein metabolism: Insights from studies in transgenic mice
79. Effects of hydrophobicity on turnover of plasma high density lipoproteins labeled with phosphatidylcholine ethers in the rat
80. Human plasma phospholipid transfer protein accelerates exchange/transfer of alpha-tocopherol between lipoproteins and cells
81. Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein
82. Phospholipid transfer protein mediates transfer of not only phosphatidylcholine but also cholesterol from phosphatidylcholine-cholesterol vesicles to high density lipoproteins
83. Antioxidant activity of phenols related to vitamin E. Are there chain-breaking antioxidants better than alpha-tocopherol?
84. Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits
85. Inhibition of LDL oxidation by antioxidants
86. Plasma phospholipid transfer protein prevents vascular endothelium dysfunction by delivering alpha-tocopherol to endothelial cells
87. Neutral lipid transfer protein does not regulate alpha-tocopherol transfer between human plasma lipoproteins
88. Gram-negative endotoxin: An extraordinary lipid with profound effects on eukeryotic signal transduction
89. The role of CD14 and lipopolysaccharide-binding protein (LBP) in the activation of different cell types by endotoxin
90. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
91. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS
92. Lipopolysaccharide-binding protein and phospholipid transfer protein release lipopolysaccharides from Gram-negative bacterial membranes
93. Phospholipid transfer protein enhances removal of cellular cholesterol and phospholipids by high-density lipoprotein apolipoproteins
94. Apolipoprotein-mediated removal of cellular cholesterol and phospholipids
95. Cholesterol efflux from Fu5AH hepatoma cells induced by plasma of subjects with or without coronary artery disease and non-insulin-dependent diabetes: Importance of LpA-I:A-II particles and phospholipid transfer protein
96. Binding of phospholipid transfer protein (PLTP) to apolipoproteins A-I and A-II: Location of a PLTP binding domain in the amino terminal region of apoA-I
97. Phospholipid transfer protein (PLTP) causes proteolytic cleavage of apolipoprotein A-I
98. Carboxyl-terminal domain truncation alters apolipoprotein A-I in vivo catabolism
99. Serum phospholipid transfer protein activity and genetic variation of the PLTP gene
100. Elevated plasma cholesteryl ester transfer in NIDDM: Relationships with apolipoprotein B-containing lipoproteins and phospholipid transfer protein
101. Effect of adiposity on plasma lipid transfer protein activities: A possible link between insulin resistance and high density lipoprotein metabolism
102. Plasma phospholipid transfer protein activity is related to insulin resistance: Impaired acute lowering by insulin in obese type II diabetic patients
103. Influence of insulin sensitivity and the TaqIB cholesteryl ester transfer protein gene polymorphism on plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities and their response to hyperinsulinemia in non-diabetic men
104. Lowering of plasma phospholipid transfer protein activity by acute hyperglycaemia-induced hyperinsulinaemia in healthy men
105. Acute and chronic effects of a 24-hour intravenous triglyceride emulsion challenge on plasma lecithin: Cholesterol acyltransferase, phospholipid transfer protein, and cholesteryl ester transfer protein activities
106. PLTP activity in premenopausal women: Relationship with lipoprotein lipase, HDL, LDL, body fat, and insulin resistance
107. Relationship between plasma phospholipid transfer protein activity and HDL subclasses among patients with low HDL and cardiovascular disease
108. Multiple abnormalities in the transfer of phospholipids from VLDL and LDL to HDL in non-insulin-dependent diabetes
109. Altered transfer of cholesteryl esters and phospholipids in plasma from alcohol abusers
110. Higher high density lipoprotein cholesterol associated with moderate alcohol consumption is not related to altered plasma lecithin:cholesterol acyltransferase and lipid transfer protein activity levels
111. Higher plasma lipid transfer protein activities and unfavorable lipoprotein changes in cigarette-smoking men
112. Decreased postprandial high density lipoprotein cholesterol and apolipoproteins A-I and E in normolipidemic smoking men: Relations with lipid transfer proteins and LCAT activities
113. Stearic acid, trans fatty acids, and dairy fat: Effects on serum and lipoprotein lipids, apolipoproteins, lipoprotein(a), and lipid transfer proteins in healthy subjects
114. Variations in serum cholesteryl ester transfer and phospholipid transfer activities in healthy women and men consuming diets enriched in lauric, palmitic or oleic acids
115. Mass concentration of plasma phospholipid transfer protein in normolipidemic, type IIa hyperlipidemic, type IIb hyperlipidemic, and non-insulin-dependent diabetic subjects as measured by a specific ELISA
116. Quantification of human plasma phospholipid transfer protein (PLTP): Relationship between PLTP mass and phospholipid transfer activity
117. Measurement of human phospholipid transfer protein by sancwich enzyme-linked immunosorbent assay
118. The distribution of phospholipid transfer protein (PLTP) in human plasma: Presence of two forms of PLTP one catalytically active and the other inactive
119. Characterization and functional studies of lipoproteins, lipid transfer proteins, and lecithin:cholesterol acyltransferase in CSF of normal individuals and patients with Alzheimer's disease
120. The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans
121. Relation of polymorphisms in the cholesteryl ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkers
122. Effect of growth hormone replacement therapy on plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities in growth hormone-deficient adults
123. Plasma lipoprotein distribution and lipid transfer activities in patients with type IIb hyperlipidemia treated with simvastatin