The BPI/LBP family of proteins: A structural analysis of conserved regions

Protein Science

Volumn 7, Issue 4, 1998, Pages 906-914

  Beamer, Lesa J ^a   Carroll, Stephen F ^b   Eisenberg, David ^c  

^a University of Missouri   (United States)

^b XOMA Corporation   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bacterial proteins; Homology modeling; LPS binding; X ray crystallography

Indexed keywords

BACTERICIDAL PERMEABILITY INCREASING PROTEIN; BINDING PROTEIN; LIPOPOLYSACCHARIDE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BACTERICIDAL ACTIVITY; CRYSTAL STRUCTURE; HYDROGEN BOND; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

BACTERIA (MICROORGANISMS); MAMMALIA; NEGIBACTERIA;

EID: 0031967690     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560070408     Document Type: Article

References (34)

1. Abrahamson SL, Wu H-M, Williams RE, Der K, Ottah N, Little R, Gazzano-Santora H, Theofan G, Bauer R, Leigh S, Orme A, Horwitz AH, Carroll SH. 1997. Biochemical characterization of recombinant fusions of lipopolysaccharide-binding protein and bactericidal/permeability-inereasing protein: Implications in biological activity. J Biol Chem 272:2149-2155.
2. Beamer LJ, Carroll SF, Eisenberg D. 1997. Crystal structure of human BPI and two bound phospholipids at 2.4 Å resolution. Science 276:1861-1864.
3. Bowie JU, Luethy R, Eisenberg D. 1991. A method to identify protein sequences that fold into a known three-dimensional structure. Science 253:164-170.
4. Brunger AT. 1990. X-PLOR: A system for crystallography and NMR. New Haven, Connecticut: Yale University Press.
5. Camussi G, Montrucchio G, Dominioni L, Dionigi R. 1995. Septic shock - The unraveling of molecular mechanisms. Nephrol Dial Transplant 10:1808-1813.
6. Carson M. 1991. Ribbons 2.0. J Appl Crystallogr 24:958-961.
7. Chung SY, Subbiah S. 1996. A structural explanation for the twilight zone of protein sequence homology. Structure 4:1123-1127.
8. Colovos C, Yeates T. 1993. Verification of protein structures: Patterns of non-bonded contacts. Protein Sci 2:1511-1519.
9. Connolly ML. 1983. Solvent-accessible surfaces of proteins and nucleic acids. Science 221:709-713.
10. Elsbach P, Weiss J. 1995. Prospects for use of recombinant BPI in the treatment of Gram-negative bacterial infections. Infectious Agents Dis 4:102-109.
11. 2+-dependent phospholipases. J Biol Chem 260:1618-1622.
12. Gazzano-Santoro H, Meszaros K, Birr C, Carroll SF, G T, Horwitz AH, Lim E, Aberle S, Kasler H, Parent JB. 1994. Competition between rBPI23, a recombinant fragment of bactericidal/permeability-increasing protein, and lipopolysaccharide (LPS)-binding protein for binding to LPS and gram-negative bacteria. Infect Immun 62:1185-1191.
13. Gazzano-Santoro H, Parent RB, Grinna L, Horwitz A, Parsons T, Theofan G, Elsbach P, Weiss J, Conlon PJ. 1992. High-affinity binding of the bactericidal/ permeability-increasing protein and a recombinant amino-terminal fragment to the lipid A region of lipopolysaccharide. Infect Immun 60:4754-4761.
14. Hailman E, Albers JJ, Wolfbauer G, Yu A-Y, Wright SD. 1996. Neutralization and transfer of lipopolysaccharide by phospholipid transfer protein. J Biol Chem 271:12172-12178.
15. Han J, Mathison JC, Ulevitch RJ, Tobias PS. 1994. Lipopolysaccharide (LPS)-binding protein, truncated at Ile-197 binds LPS but does not transfer LPS to CD14. J Biol Chem 269:8172-8175.
16. Higgins DG, Sharp PM. 1989. CLUSTAL: A package for performing multiple sequence alignment on a microcomputer. Gene 73:237-244.
17. Horwitz AH, Williams RE, Nowakowski G. 1995. Human lipopolysaccharide-binding protein potentiates bactericidal activity of human bactericidal/ permeability-increasing protein. Infect Immun 62:522-527.
18. Iovine NM, Elsbach P, Weiss J. 1997. An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N-and C-terminal domains. Proc Natl Acad Sci USA 94:10973-10978.
19. Lamping N, Hoess A, Yu B, Park TC, Kirschning C-J, Pfeil D, Reuter D, Wright SD, Herrmann F, Schumann RR. 1996. Effects of site-directed mutagenesis of basic residues (Arg94, Lys95, Lys99) of lipopolysaccharide (LPS)-binding protein on binding and transfer of LPS and subsequent immune cell activation. J Immunol 157:4648-4656.
20. Little RG, Kelner DN, Lim E, Burke DJ, Conlon PJ. 1994. Functional domains of recombinant bactericidal/permeability increasing protein (rBPI23). J Biol Chem 268:1865-1872.
21. Luthy R, Bowie JU, Eisenberg D. 1992. Assessment of protein models with three-dimensional profiles. Nature 356:83-85.
22. Mannion BA, Weiss J, Elsbach P. 1990. Separation of lethal and sub-lethal effects of the bactericidal/permeability-increasing protein. J Clin Invest 85:853-860.
23. Nicholls A, Sharp KA, Honig B. 1991. Protein folding and association: Insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11:281-296.
24. Ooi CE, Weiss J, Doerfler ME, Elsbach P. 1991. Endotoxin-neutralizing properties of the 25 kDa N-terminal fragment and a newly isolated 30 kD C-terminal fragment of the 55-60 kD bactericidal/permeability-increasing protein of human neutrophils. J Exp Med 174:649-655.
25. Pugin J, Schurer-Maly C-C, Leturcq D, Moriarty A, Ulevitch RJ, Tobias PS. 1993. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci USA 90:2744-2748.
26. Raetz CR. 1996. Bacterial lipopolysaccharides: A remarkable family of bioactive macroamphiphiles. In: Niedhardt FG, ed. Escherichia coli and Salmonella: Cellular and molecular biology. Washington, DC: ASM Press, pp 1035-1063.
27. Schromm AB, Branderburg K, Rietschel ET, Flad H-D, Carroll SF, Seydel U. 1996. Lipopolysaccharide-binding protein mediates CD14-independent interaction of lipopolysaccharide into phospholipid membranes. FEBS Lett 399:267-271.
28. Theofan G, Horwitz AH, Williams RE, Liu P-S, Chan I, Birr C, Carroll SF, Meszaros K, Parent JB, Kasler H, Aberle S, Trown PW, Gazzano-Santoro H. 1994. An amino-terminal fragment of human lipopolysaccharide-binding protein retains lipid A binding but not CD14-stimulatory activity. J Immunol 152:3623.
29. Tobias PS, Mathison JC, Ulevitch RJ. 1988. A family of lipopolysaccharide-binding proteins involved in responses to Gram-negative sepsis. J Biol Chem 263:13479-12481.
30. Tobias PS, Soldau K, Iovine NM, Elsbach P, Weiss J. 1997. Lipopolysaccharide (LPS)-binding proteins BPI and LBP for different types of complexes with LPS. J Biol Chem 272:18682-18685.
31. Weiss J, Olson I. 1987. Cellular and subcellular localization of the bactericidal/ permeability-increasing protein of neutrophils. Blood 69:652-659.
32. Weiss J, Victor M, Elsbach P. 1983. Role of charge and hydrophobic interactions in the action of the bactericidal/permeability-increasing protein of neutrophils on Gram-negative bacteria. J Clin Invest 71:540-549.
33. Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. 1990. CD14, a receptor for complex of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433.
34. Wurfel MM, Kunitake ST, Lichenstein HS, Kane JP, Wright SD. 1994. Lipopolysaccharide (LPS)-binding protein is carried on lipoproteins and acts as a cofactor in the neutralization of LPS. J Exp Med 180:1025-1035.