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Jiang XC, Bruce C, Cocke T, Wang S, Boguski M, Tall AR. Point mutagenesis of positively charged amino acids of cholesteryl ester transfer protein: conserved residues within the lipid transfer/lipopolysaccharide binding protein gene family essential for function. Biochemistry. 34:1995;7258-7263.
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Human plasma cholesteryl ester transfer protein consists of a mixture of two forms reflecting variable glycosylation at asparagine 341
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of outstanding interest. This study shows striking differences in the physical properties of the LPS-BPI and LPS-LBP complexes, despite the structural similarity between BPI and LBP. Unlike LBP, which is unable to disaggregate LPS, BPI appears to associate with, but not disperse. LPS aggregates.
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Tobias PS, Soldau K, Iovine NM, Elsbach P, Weiss J. Lipopolysaccharide (LPS)-binding proteins LBI and LBP form different types of complexes with LPS. of outstanding interest J Biol Chem. 272:1997;18682-18685 This study shows striking differences in the physical properties of the LPS-BPI and LPS-LBP complexes, despite the structural similarity between BPI and LBP. Unlike LBP, which is unable to disaggregate LPS, BPI appears to associate with, but not disperse. LPS aggregates.
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