Increased preβ-high density lipoprotein, apolipoprotein Al, and phospholipid in mice expressing the human phospholipid transfer protein and human apolipoprotein Al transgenes

Journal of Clinical Investigation

Volumn 98, Issue 10, 1996, Pages 2373-2380

  Jiang, Xian Cheng ^a   Francone, Omar L ^b   Bruce, Can ^a   Milne, Ross ^d   Mar, Jefferson ^a   Walsh, Annemarie ^c   Breslow, Jan L ^b   Tall, Alan R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b PFIZER INC   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d UNIVERSITY OF OTTAWA   (Canada)

Author keywords

apolipoproteins A; carrier proteins; HDL lipoproteins; phospholipids; transgenic mice

Indexed keywords

APOLIPOPROTEIN A1; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN; PHOSPHOLIPID; PHOSPHOLIPID TRANSFER PROTEIN; APOLIPOPROTEIN; CARRIER PROTEIN; CHOLESTEROL; DNA; LIPOPROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY; RNA;

ANIMAL CELL; ARTICLE; ATHEROGENESIS; EMBRYO; HUMAN; HUMAN CELL; LIPOPROTEIN BLOOD LEVEL; MOLECULAR CLONING; MOUSE; NONHUMAN; PARTICLE SIZE; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SECRETION; REGULATORY MECHANISM; TISSUE DISTRIBUTION; TRANSGENIC MOUSE; ANIMAL; BLOOD; BRAIN; C57BL MOUSE; CBA MOUSE; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEART MUSCLE; IMMUNOLOGY; KIDNEY; LIVER; LUNG; METABOLISM; MUSCLE; NUCLEIC ACID HYBRIDIZATION; SMALL INTESTINE; SPLEEN; WESTERN BLOTTING;

ANIMALS; ANTIBODIES, MONOCLONAL; APOLIPOPROTEIN A-I; APOLIPOPROTEINS; BLOTTING, WESTERN; BRAIN; CARRIER PROTEINS; CHOLESTEROL; CHOLESTEROL ESTERS; CLONING, MOLECULAR; DNA; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTESTINE, SMALL; KIDNEY; LIPOPROTEINS; LIPOPROTEINS, HDL; LIVER; LUNG; MEMBRANE PROTEINS; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MICE, TRANSGENIC; MUSCLES; MYOCARDIUM; NUCLEIC ACID HYBRIDIZATION; PHOSPHOLIPID TRANSFER PROTEINS; RNA; RNA, MESSENGER; SPLEEN;

EID: 0029658538     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119050     Document Type: Article

References (40)

1. Miller, G. J., and N.E. Miller. 1975. High-density lipoprotein and atherosclerosis. Lancet. i:16-19.
2. Tall, A.R. 1986. Lipid transfer protein. J. Lipid Res. 27:359-365.
3. Tall, A.R., E. Abreu, and J. Shuman. 1983. Separation of a plasma phospholipid transfer protein from cholesterol ester/phospholipid exchange protein. J. Biol. Chem. 258:2174-2180.
4. Tollefson, J.H., S. Ravnik, and J.J. Albers. 1988. Isolation and characterization of a phospholipid transfer protein (LTP-II) from human plasma. J. Lipid Res. 29:1593-1602.
5. Tall, A.R., S. Krumholz, T. Olivecrona, and R.J. Deckelbaum. 1985. Plasma phospholipid transfer protein enhances transfer and exchange of phosphatidylcholine between VLDL and HDL during lypolysis. J. Lipid Res. 26: 842-852.
6. Jauhianinen, M., J. Metso, R., Pohlman, S. Blomquist, A. van Tol, and C. Ehnholm. 1993. Human plasma phospholipid transfer protein causes high density lipoprotein conversion. J. Biol. Chem. 268:4032-4036.
7. Tu, A.Y., H.I. Nishida, and T. Nishida. 1993. High density lipoprolein conversion mediated by human plasma phospholipid transfer protein. J. Biol. Chem. 268:23098-23105.
8. Day, J.R., J.J. Albers, C.E. Lofton-Day, T.L. Gilbert, A.F.T. Ching, F.J. Grant, P.J. O'Hara, S.M. Marcovina, and J.L. Adolphson. 1994. Complete cDNA encoding human phospholipid transfer protein from human endothelial cells. J. Biol. Chem. 269:9388-9391.
9. Albers, J.J., G. Wolfbauer, M.C. Cheung, J.R. Day, A.F. Ching, S. Lok, and A.Y. Tu. 1995. Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies. Biochim. Biophys. Acta. 1258:27-34.
10. Jiang, X.-C., and C. Bruce. 1995. Regulation of murine plasma phospholipid transfer protein activity and mRNA levels by lipopolysaccharide and high cholesterol diet. J. Biol. Chem. 270:17133-17138.
11. 3. J. Biol. Chem. 264:6488-6494.
12. Rubin, E.M., B.Y. Ishida, S.M. Clift, and R.M. Krauss. 1991. Expression of human apolipoprotein AI in transgenic mice results in reduced plasma levels of murine apolipoprotein AI and the appearance of two new high density lipoprotein size subclasses. Proc. Natl. Acal. Sci. USA. 88:434-438.
13. Francone, O.L., E.L. Gong, D.S. Ng, C.J. Fielding, and E.M. Rubin. 1995. Expression of human lecithin-cholesterol acyltransferase in transgenic mice. Effect of human apolipoprotein AI and human apolipoprotein AII on plasma lipoprotein cholesterol metabolism. J. Clin. Invest. 96:1440-1448.
14. Hayek, T., T. Chajek-Shaul, A. Walsh, L.B. Agellon, P. Moulin, A.R. Tall, and J.L. Breslow. 1992. An interaction between the human cholesteryl esler transfer protein (CETP) and apolipoprotein AI genes in transgenic mice results in a profound CETP-mediated depression of high density lipoprotein cholesterol levels. J. Clin. Invest. 90:505-510.
15. Melton, D.A., P.A. Krieg, M.R. Rebagliati, T. Maniatis, and M.R. Green. 1984. Efficient in vitro synthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoter. Nucleic Acids Res. 12:7035-7056.
16. Agellon, L.B., A. Walsh, T. Hayek, P. Moulin, X.-C. Jiang, S. Shelanski, J.L. Breslow, and A.R. Tall. 1991. The CCAAT/enhancer-binding protein trans-activates the human cholesleryl ester transfer protein gene promoter. J. Biol. Chem. 266:10796-10801.
17. Jiang, X.-C., L. Masucci, J. Mar, M. Lin, A. Walsh, J.L. Breslow, and A.R. Tall. 1993. Down-regulation of mRNA for the low density lipoprotein receptor in transgenic mice containing the gene for human cholesteryl ester transfer protein. J. Biol. Chem. 268:27406-27412.
18. Whitmore, T.E., J.R. Day, and J.J. Albers. 1995. Localization of the human phospholipid transfer protein gene to chromosome 20q12-13.1. Genomics. 28:599-600.
19. Wiegant, J., N.J. Galjart, A.K. Rapp, and A. d'Azzo. 1991. The gene encoding human protective protein (PPBG) is on chromosome 20. Genomics. 10: 345-349.
20. Francone, O.L., and C.J. Fielding. 1990. Initial steps in reverse cholesterol transport: the role of short-lived cholesterol acceptors. Eur. Heart J. 11(E):11218-11224.
21. Verheijen, F.W., S. Palmeri, A.T. Hoogeveen, and H. Galjaard. 1985. Human placenlal neuraminidase. Activation, stabilization and association with beta-galactosidase and its protective protein. Eur. J. Biochem. 149:315-21.
22. Itoh, K., N. Takiyama, R. Kase, K. Kondoh, A. Sano, A. Oshima, H. Sakuraba, and Y. Suzuki. 1993. Purification and characterization of human lysosomal protective protein expressed in stably transformed Chinese hamster ovary cells. J. Biol. Chem. 268:1180-1186.
23. Galjart, N.J., H. Morreau, R. Willemsen, N. Gillemans, E.J. Bonten, and A. d'Azzo. 1991. Human lysosomal protective protein has cathepsin A-like activity distinct from its protective function. J. Biol. Chem. 266:14754-14762.
24. Shimmoto, M., T. Takano, Y. Fukuhara, A. Oshima, H. Sakuraba, and Y. Suzuki. 1990. Japanese-type adult galactosialidosis: a unique splice junction mutation causing exon skipping in the protective protein/carboxypeptidase gene. Proc. Jpn. Acad. 668:217-222.
25. Ishida, B.Y., D. Albee, and B. Paigen. 1990. Interconversion of prebeta-migrating lipoproteins containing apolipoprotein AI and HDL. J. Lipid Res. 31: 227-236.
26. Castle, C.K., M.E. Pape, K.R. Marotti, and G.W. Melchior. 1991. Secretion of pre-beta-migrating apoA-I by cynomolgus monkey hepatocytes in culture. J. Lipid Res. 32:439-447.
27. Lefevre, M., C.H. Sloop, and P.S. Roheim. 1988. Characterization of dog prenodal peripheral lymph lipoproteins. Evidence for the peripheral formation of lipoprotein-unassocialed apoA-I with slow pre-beta electrophoretic mobility. J. Lipid Res. 29:1139-1148.
28. Ishida, B.Y, J. Frolich, and C.J. Fielding. 1987. Prebeta-migrating high density lipoprotein: quantitation in normal and hyperlipidemic plasma by solid phase radioimmunoassay following electrophoretic transfer. J. Lipid Res. 28: 778-786.
29. Reichl, D., C.B. Hathaway, J.M. Sterchi, and N.B. Miller. 1991. Lipoproteins of human peripheral lymph. Apolipoprotein AI-cortaining lipoprotein with alpha eletrophoretic mobility. Eur. J. Clin. Invest. 21:638-643.
30. Smith, E.B., C. Ashall, and J.E. Walker. 1984. High density lipoprotein (HDL) subfractions in interstitial fluid from human aortic intima and atherosclerotic lesions. Biochem. Soc. Trans. 12:843-844.
31. Neary, R.H., and E. Gowland. 1987. Stability of free apolipoprotein AI concentration in serum, and its measurement in normal and hyperlipidemic subjects. Clin. Chem. 33:1163-1169.
32. Hara, H., and S. Yokoyama. 1992. Role of apolipoproteins in cholesterol efflux from macrophages to lipid microemulsion proposal of a putative model for the pre-beta high density lipoprotein pathway. Biochemistry. 31: 2040-2046.
33. Huang, Y., A. van Eckardstein, and G. Assmann. 1993. Cell-derived cholesterol cycles between different HDLs and LDL for its effective esterification in plasma. Arterioscler. Thromb. 13:445-458.
34. Fisher, W.R., V. Venkatakrishnan, L.A. Zech, C.M. Hall, L.L. Kilgore, P.W. Stacpoole, M.R. Diffenderfer, K.E. Friday, A.E. Sumner, and J.B. Marsh. 1995. Kinetic evidence for both a fast and a slow secretary pathway for apolipoprotein AI in humans. J. Lipid Res. 36:1618-1628.
35. Clay, M.A., H.H. Newnham, T.M. Forte, and P.I. Barter. 1991. Cholesteryl ester transfer protein and hepatic lipase activity promote shedding of apoA-I from HDL and subsequent formation of discoidal HDL. Arterioscler. Thromb. 11:415-421.
36. Kunitake, S.T., C.M. Mendel, and L.M. Henessy. 1992. Interconversion between apolipoprotein A-I-containing lipoproteins of pre-beta and alpha mobilities. J. Lipid Res. 33:1807-1816.
37. Barrans, A.X., X. Collet, R. Barbaras, B. Jaspard, J. Manent, V.H. Chap, and B. Perret. 1994. Hepatic lipase induces the formation of pre-beta high density lipoprotein (HDL) from triacylglycerol-rich HDL2.7. Biol. Chem. 269:11572-1157733.
38. Glomset, J.A. 1968. The plasma lecithins: cholesterol acyltransferase reaction. J. Lipid Res. 9:155-167.
39. Nichols, A.V., E.L. Gong, P.J. Blanche, T.M. Forte, and V.G. Shore. 1987. Pathways in the formation of human plasma high density lipoprotein subpopulations containing apolipoprotein A-I without apolipoprotein A-II. J. Lipid Res. 28:719-732.
40. Lusa, S., M. Jauhiainen, J. Metso, P. Somerharju, and C. Enholm. 1996. The mechanism of human plasma phospholipid transfer protein-induced enlargement of high-density lipoprotein particles: evidence for particle fusion. Biochem. J. 313:275-282.