Multiple signaling cascades are differentially involved in gene induction by double stranded RNA in interferon-α-primed cells

European Journal of Biochemistry

Volumn 268, Issue 5, 2001, Pages 1373-1381

  Harcourt, Jennifer L ^a   Offermann, Margaret K ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

Double stranded RNA; Erk; IL 6; Interferon; P38 MAPK

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA INTERFERON; DOUBLE STRANDED RNA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; POLYCYTIDYLIC ACID; POLYINOSINIC ACID;

ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE INDUCTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION;

BLOTTING, WESTERN; BUTADIENES; DNA-BINDING PROTEINS; EIF-2 KINASE; ENZYME ACTIVATION; HELA CELLS; HUMANS; IMIDAZOLES; INTERFERON REGULATORY FACTOR-1; INTERFERON-ALPHA; INTERLEUKIN-1; INTERLEUKIN-6; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOPROTEINS; POLYNUCLEOTIDES; PROTEIN-SERINE-THREONINE KINASES; PYRIDINES; RNA, DOUBLE-STRANDED; RNA, MESSENGER; TRANS-ACTIVATION (GENETICS);

EID: 0035081768     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02003.x     Document Type: Article

References (65)

1. When two strands are better than one: The mediators and modulators of the cellular responses to double-stranded RNA
2. Interferon-induced and double-stranded RNA-activated enzymes: A specific protein kinase and 2′,5′-oligoadenylate synthetases
3. Activation of 2′,5′ oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers
4. Effects of varying lengths of double-stranded RNA on binding and activation of 2′,5′-oligoadenylate synthetase
5. The eIF-2α protein kinases, regulators of translation in eukaryotes from yeasts to humans
6. Interferon-induced proteins and their mechanisms of action
7. Regulation of adhesion molecule expression in Kaposi's sarcoma cells
8. Interleukin-1α mediates an alternative pathway for the antiproliferative action of poly (I:C) on human endothelial cells
9. Ebola virus inhibits induction of genes by double-stranded RNA in endothelial cells
10. Activation of the double-stranded-RNA-activated protein kinase and induction of vascular cell adhesion molecule-1 by poly (I)-poly (C) in endothelial cells
11. Regulation of IL6 gene expression
12. Induction of IL-6 gene expression in Kaposi's sarcoma cells
13. Interferon-α synergistically enhances induction of IL-6 by double stranded RNA in HeLa cells
14. Modulation of double-stranded RNA-mediated gene induction by interferon in human umbilical vein endothelial cells
15. Double-stranded RNA-dependent protein kinase activates transcription factor NF-κB by phosphorylating IκB
16. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: Role of IRF-1 and NF-κB
17. Blockage of NF-κB signaling by selective ablation of an mRNA target by 2-5A antisense chimeras
18. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase
19. Activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase by double-stranded RNA and ence-phalomyocarditis virus: Involvement of RNaseL, protein kinase R, and alternative pathways
20. MAPKs: New JNK expands the group
21. Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors
22. Distinct roles for p42/p44 and p38 mitogen-activated protein kinases in the induction of IL-2 by IL-1
23. Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin
24. Interferon b2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells
25. Multiple actions of interleukin 6 within a cytokine network
26. IL-6 acts on endothelial cells to preferentially increase their adherence for lymphocytes
27. Induction of in vitro human lymphocyte migration by interleukin-6
28. A cytokine network in human diploid fibroblasts: Interactions of beta interferons, tumor necrosis factor, platelet-derived growth factor, and interleukin-1
29. IL-1 stimulates IL-6 production in endothelial cells
30. Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: Role in the induction of interleukin 6
31. An overview of the interferon system: Signal transduction and mechanisms of action
32. Phosphorylated interferon-α receptor 1 subunit (IFNκR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein
33. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway
34. Tyrosine-phosphorylated Stat1 and Stat2 plus a 48-kDa protein all contact DNA in forming interferon-stimulated-gene factor 3
35. Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein
36. p38 Map kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons
37. Activation of the p38 mitogen-activated protein kinase by type I interferons
38. Interleukin 4 is at 5q31 and interleukin 6 is at 7p15
39. Structure of two forms of the interferon-induced (2′5′)-oligo A synthetase of human cells based on cDNAs and gene sequences
40. Primary structure of ICAM21 demonstrates interaction between members of the immunoglobulin and integrin supergene families
41. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon
42. A truncated form of the IRF-2 transcription factor has the properties of a postinduction repressor of interferon-β gene expression
43. Sequence identification of 2,375 human brain genes
44. Pyridinylimidazole compound SB 203580 inhibits the activity but not the activation of p38 mitogen-activated protein kinase
45. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site
46. Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
47. Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
48. Use of a drug-resistant mutant of stress-activated protein kinase 2a/p38 to validate the in vivo specificity of SB 203580
49. The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
50. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
51. Identification of a novel inhibitor of mitogen-activated protein kinase kinase
52. Mechanism of interferon action: Evidence for intermolecular autophosphorylation and autoactivation of the interferon-induced, RNA-dependent protein kinase PKR
53. Regulation of the interferon-inducible protein kinase PKR and (2′,5′) oligo (adenylate) synthetase by a catalytically inactive PKR mutant through competition for double-stranded RNA binding
54. The regulation of the protein kinase PKR by RNA
55. PKR - A protein kinase regulated by double-stranded RNA
56. Specificity and mechanism of action of some commonly used protein kinase inhibitors
57. Tumor necrosis factor a-induced E-selectin expression is activated by the nuclear factor-κB and c-jun N-terminal kinase/p38 mitogen-activated protein kinase pathways
58. Stimulation of p38 phosphorylation and activity by arachidonic acid in HeLa cells, HL60 promyelocytic leukemic cells, and human neutrophils. Evidence for cell type-specific activation of mitogen-activated protein kinases
59. MKP5, a new member of the MAP kinase phosphatase family, which selectively dephosphorylates stress-activated kinases
60. Independent regulation of JNK/p38 mitogen-activated protein kinases by metabolic oxidative stress in the liver
61. New insights into the control of MAP kinase pathways
62. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
63. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction
64. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6
65. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism