Cyclic AMP-dependent inhibition of human neutrophil oxidative activity by substituted 2-propynylcyclohexyl adenosine A2A receptor agonists

British Journal of Pharmacology

Volumn 132, Issue 5, 2001, Pages 1017-1026

  Sullivan, Gail W ^a   Rieger, Jayson M ^b   Michael Scheld, W ^a   Macdonald, Timothy L ^b   Linden, Joel ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

Cyclic AMP dependent protein kinase; Neutrophil; Oxidative burst

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 4 [3 [6 AMINO 9 (5 ETHYLCARBAMOYL 3,4 DIHYDROXYTETRAHYDRO 2 FURYL) 9H PURIN 2 YL] 2 PROPYNYL]CYCLOHEXANECARBOXYLIC ACID METHYL ESTER; 6 N (5 HYDROXYNORBORNAN 2 YL) 8 (N ISOPROPYL N METHYLAMINO) 9 METHYLADENINE; 8 (N METHYLISOPROPYL)AMINO N6 (5' ENDOHYDROXYENDONORBORNYL) 9 METHYLADENINE; 9 CHLORO 2 (2 FURYL) 5 PHENYLACETYLAMINO 1,2,4 TRIAZOLO[1,5 C]QUINAZOLINE; ACETIC ACID 4 [3 [6 AMINO 9 (5 ETHYLCARBAMOYL 3,4 DIHYDROXYTETRAHYDROFURAN 2 YL) 9H PURIN 2 YL]PROP 2 YNYL]CYCLOHEXYLMETHYL ESTER; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE DERIVATIVE; ATL 193; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; N (4 CYANOPHENYL) 2 [4 (2,3,6,7 TETRAHYDRO 2,6 DIOXO 1,3 DIPROPYL 1H PURIN 8 YL)PHENOXY]ACETAMIDE; N (4 CYANOPHENYL) 2 [4 (2,6 DIOXO 1,3 DIPROPYL 2,3,4,5,6,7 HEXAHYDRO 1H PURIN 8 YL)PHENOXY]ACETAMIDE; RECEPTOR SUBTYPE; ROLIPRAM; UNCLASSIFIED DRUG;

ARTICLE; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; NEUTROPHIL; PRIORITY JOURNAL; REACTION ANALYSIS; RECEPTOR AFFINITY; RESPIRATORY BURST; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0035076437     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703893     Document Type: Article

References (51)

1. 2A adenosine receptor mediates coronary vasodilation
2. Protein kinase A downregulates the phosphorylation of p47 phox in human neutrophils: A possible pathway for inhibition of the respiratory burst
3. 558 of NADPH oxidase by phosphorylation of Rap1A
4. 3 receptors
5. Adenosine a(3) receptor agonists inhibit murine macrophage tumor necrosis factor-alpha production in vitro and in vivo
6. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells
7. 2 adenosine receptors
8. - generation, respectively
9. Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neutrophil
10. Occupancy of adenosine receptors raises cyclic AMP alone and in synergy with occupancy of chemoattractant receptors and inhibits membrane depolarization
11. Adenosine: A physiological modulator of superoxide anion generation by human neutrophils
12. 2 receptors
13. The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation
14. Adenosine regulates the respiratory burst of cytokine-triggered human neutrophils adherent to biological surfaces
15. Mechanism of the luminol-dependent chemiluminescence of human neutrophils
16. Labeling of A(2a) Adenosine receptors in human platelets by use of the new nonxanthine antagonist radioligand [H-3]Sch 58261
17. Optimal conditions for simultaneous purification of mononuclear and polymorphonuclear leucocytes from human blood by the hypaque-ficoll method
18. Inhibition of phospholipase D blocks activation of fibrinogen-adherent neutrophils by tumor necrosis factor
19. 2A receptors mediate the inhibitory effect of adenosine on formyl-met-leu-phe-stimulated respiratory burst in neutrophil leucocytes
20. 2A adenosine receptors in human peripheral blood cells
21. s effector Pathway
22. An agonist of adenosine a(3) receptors decreases interleukin-12 and interferon-gamma production and prevents lethality in endotoxemic mice
23. Adenosine receptor agonists differentially regulate Il-10, TNF-alpha and nitric oxide production in raw 264.7 macrophages and in endotoxemic mice
24. 2 selective adenosine receptor agonist with preferential hypotensive activity
25. Adenosine A(3) receptors - Novel ligands and paradoxical effects
26. 2 receptors in rat brain
27. 2B adenosine receptors
28. Elevation of intracellular cAMP inhibits RhoA activation and integrin-dependent leukocyte adhesion induced by chemoattractants
29. 125I]iodophenyl)ethylamino]adenosine
30. 2A receptor agonist that produces selective coronary vasodilation
31. 1 adenosine receptors
32. 2 receptor agonists with potent antihypertensive effects
33. Reversal of inhibitory pathways in neutrophils by protein kinase antagonists: A rational approach to the restoration of depressed cell function
34. 2-(N′-alkylidenehydrazino)adenosines: Potent and selective coronary vasodilators
35. Selective A(2A) adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney
36. Pharmacology of adenosine. A(2A) receptors
37. 2A selective adenosine receptor antagonist
38. Effect of adenosine analogues and cAMP-raising agents on TNF-GM-CSF, and chemotactic peptide-induced degranulation in single adherent neutrophils
39. Immunohistochemical localization of adenosine A(2a) receptors in the rat central nervous system
40. Selective adenosine-A(2A) activation reduces lung reperfusion injury following transplantation
41. 2 receptors are inhibitory
42. Drug antagonism and pAx
43. Stereospecific binding of the antidepressant rolipram to brain protein structures
44. Disruption of the A(3) adenosine receptor gene in mice and its effect on stimulated inflammatory cells
45. A(2A)-Adenosine receptor reserve for coronary vasodilation
46. The specific type IV phosphodiesterase inhibitor rolipram combined with adenosine reduces tumor necrosis factor-alpha-primed neutrophil oxidative activity
47. Role of A(2A) adenosine receptors in inflammation
48. 2A adenosine receptor inhibits inflammation in a rat model of meningitis: Synergy with the type IV phosphodiesterase inhibitor, rolipram
49. Suppression of macrophage in inflammatory protein (Mip)-1-alpha production and collagen-induced arthritis by adenosine receptor agonists
50. Adenosine receptor occupancy suppresses chemoattractant-induced phospholipase D activity by diminishing membrane recruitment of small GTPases
51. 2 receptors, adenosine inhibits the upregulation of Mac-1 (Cd11b/CD18) expression on FMLP-stimulated neutrophils