Pharmacology of 2-cyclohexylmethylidenehydrazinoadenosine (WRC-0470), a novel, short-acting adenosine A(2A) receptor agonist that produces selective coronary vasodilation

Drug Development Research

Volumn 40, Issue 4, 1997, Pages 313-324

  Martin, Pauline L ^a   Barrett, Richard J ^a   Linden, Joel ^b   Abraham, William M ^c  

^a ADERIS Pharmaceuticals Inc   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

^c UNIVERSITY OF MIAMI   (United States)

Author keywords

A(2A) agonist; Adenosine; Coronary blood flow; Hemodynamics; Pulmonary

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CYCLOHEXYLMETHYLIDENEHYDRAZINOADENOSINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE RECEPTOR; BINODENOSON; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTHMA; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; DOG; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; GUINEA PIG; HEMODYNAMICS; INTRAVENOUS DRUG ADMINISTRATION; LUNG FUNCTION; NONHUMAN; RECEPTOR AFFINITY; SHEEP;

EID: 0030880492     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199704)40:4<313::AID-DDR5>3.0.CO;2-M     Document Type: Article

References (26)

1. Abraham WM and Baugh LE (1995): Animal models of asthma. In Busse WW, Holgate ST (eds): Asthma and Rhinitis. Blackwell Scientific, pp 961-977.
2. Abreu A, Mahmarian JJ, Nishimura S, Boyce TM, Verani MS (1991): Tolerance and safety of pharmacologic coronary vasodilation with adenosine in association with thalluim-201 scintigraphy in patients with suspected coronary artery disease. J Am Coll Cardiol 18:730-735.
3. Belardinelli L (1993): Adenosine systems in the heart. Drug Dev Res 28:263-267.
4. Beller GA (1990): Dipyridamole thallium 201 imaging - How safe is it? Circulation 81:1425-1427.
5. 1 adenosine receptor-mediated effects in humans. Circulation 93:1871-1876.
6. Cerqueira MD, Verani MS, Schwaiger M, Heo J, Iskandrian AS (1994): Safety profile of adenosine stress perfusion imaging: results from the adenosean multicenter trial registry. J Am Col Cardiol 23:384-389.
7. Church MK, Holgate ST (1993): Adenosine-induced broncho-constriction and its inhibition by nedocromil sodium. J Allergy Clin Immunol 92:190-194.
8. 2B receptor evoke interleukin-8 secretion in human mast cells, an enprofylline-sensitive mechanism with implications for asthma. J Clin Invest 96:1979-1986.
9. Firschke C, Lindner JR, Goodman NC, Skyba DM, Wei K, Kaul S (1997): Myocardial contrast echocardiography in acute myocardial infarction using aortic root injections of microbubbles in conjunction with hannonic imaging: Potential application in the cardiac catheterization laboratory. J Am Coll Cardiol 92:207-216.
10. 2A receptor agonist. Circulation 94:1726-1732.
11. Howell LL (1993): Effect of adenosine agonists on ventilation during hypercapnia, hypoxia and hyperoxia in rhesus monkeys. J Pharmacol Exp Ther 265:971-978.
12. Johnson DL, Daley JR, Hodge DO, Hopfenspirger MR, Gibbons RJ (1995): Hemodynamic responses and adverse effects associated with adenosine and dipyridamole pharmacologic stress testing: A comparison in 2,000 patients. Mayo Clin Proc 70:331-336.
13. Lansing MW, Mansour E, Ahmed A, Cortes A, Garcia L, Lauredo IT, Wanner A, Abraham WM (1991): Lipid mediators contribute to oxygen-radical-induced air-way responses in sheep. Am Rev Respir Dis 144:1291-1296.
14. Linden J (1982): Calculating the dissociation constant of an unlabeled compound from the concentration required to displace radiolabel binding by 50%. J Cyclic Nucleotide Res 8:163-172.
15. 3-receptors: Pharmacological properties, species differences and receptor function. Trends Pharmacol Sci 15:298-306.
16. 125I]Aminobenzyladenosine, a new radioligand with improved specific binding to adenosine receptors in heart. Circ Res 56:279-284.
17. 3-adenosine receptor with widespread tissue distribution. Mol Pharmacol 44:524-532.
18. 125I]iodophenyl)-ethylamino]-adenosine. Mol Pharmacol 47:307-313.
19. 2 adenosine receptors in the aorta and the coronary vessels from the guinea pig. J Pharmacol Exp Ther 265:248-253.
20. Niiya K, Olsson RA, Thompson RD, Silvia SK, Ueeda M (1992): 2-(N′-Alkylidine-hydrazino)adenosines: Potent and selective coronary vasodilators. J Med Chem 35:4557-1561.
21. Philips GD, Ng WH, Church MH, Holgate ST (1990): The response of plasma histamine to bronchoprovocation with methacholine, adenosine 5-monophosphate, and allergen in atopic nonasthmatic subjects. Am Rev Respir Dis 141:9-13.
22. Philips CD, Holgate ST (1995): Adenosine and the airways in asthma. In Busse WW, Holgate ST (eds): Asthma and Rhinitis. Blackwell Scientific, pp 851-857.
23. 3-adenosine receptor is the unique adenosine receptor which facilitates release of allergic mediators in mast cells. J Biol Chem 23:16887-16890.
24. Robeva ASR, Woodard DR, Luthin DR, Taylor HE, Linden J (1996): Double tagging recombinant A2-and A2A-adenosine receptors with hexahistadine and the FLAG epitome - development of an efficient generic protein purification procedure. Biochem Pharmacol 51:545-555.
25. Tucker A, Linden J (1992): Cloned receptors and cardiovascular responses to adenosine. Cardiovasc Res 27:62-67.
26. Verani MS (1993): Pharmacologic stress myocardial perfusion imaging. Curr Probl Cardiol 18:483-525.