Suppression of macrophage inflammatory protein (MIP)-1α production and collagen-induced arthritis by adenosine receptor agonists

British Journal of Pharmacology

Volumn 125, Issue 2, 1998, Pages 379-387

  Szabó, Csaba ^a   Scott, Gwen S ^a   Virág, László ^a   Egnaczyk, Greg ^a   Salzman, Andrew L ^a   Shanley, Thomas P ^a   Haskó, György ^b  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b INOTEK CORPORATION   (United States)

Author keywords

Arthritis; Cytokines; Inflammation; Xanthine

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 2 CHLORO 6 N CYCLOPENTYLADENOSINE; 3 NITROTYROSINE; 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; ADENOSINE A1 RECEPTOR; ADENOSINE A2 RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; CHEMOKINE; COLLAGEN; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 6; LIGAND; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MESSENGER RNA; NITRIC OXIDE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CELL CULTURE; CELL INFILTRATION; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE COURSE; DISEASE SEVERITY; INFLAMMATION; MACROPHAGE; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; ANIMALS; ARTHRITIS; CELLS, CULTURED; COLLAGEN; CYTOKINES; DISEASE MODELS, ANIMAL; GENE EXPRESSION; MACROPHAGE ACTIVATION; MACROPHAGE INFLAMMATORY PROTEIN-1; MACROPHAGES; MICE; MICE, INBRED DBA; RECEPTORS, PURINERGIC P1; RNA, MESSENGER;

EID: 0031691973     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702040     Document Type: Article

References (39)

1. AL-MUGHALES, J., BLYTH, T.H., HUNTER, J.A. & WILKINSON, P.C. (1996). The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokines. Clin. Exp. Immunol., 106, 230-236.
2. AUCHAMPACH, J.A., RIZVI, A., QIU, Y., TANG, X.L., MALDONADO, C., TESCHNER, S.A. & BOLLI, R. ( 1997). Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl) adenosine-5′-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbits. Circ. Res., 80, 800-809.
3. BECKMAN, J.S. & KOPPENOL, W.H. (1996). Nitric oxide. Superoxide, and peroxynitrite: the good, the bad, and ugly. Am. J. Physiol., 271, C1424-C1437.
4. COLLIS, M.G. & HOURANI, S.M. (1993). Adenosine receptor subtypes. Trends Pharmacol. Sci., 14, 360-366.
5. CONNOR, J.R., MANNING, P.T., SETTLE, S.L., MOORE, W.M., JEROME, G.M., WEBBER, R.K., TJOENG, F.S. & CURRIE, M.G. (1995). Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. Eur. J. Pharmacol., 273, 15-24.
6. CRONSTEIN, B.N. (1994). Adenosine, an endogenous anti-inflammatory agent. J. Appl. Physiol., 76, 5-13.
7. CRONSTEIN, B.N., EBERLE, M.A., GRUBER, H.E. & LEVIN, R.I. (1991). Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. Proc. Natl. Acad. Sci. USA, 88, 2441-2445.
8. CRONSTEIN, B.N., NAIME, D. & OSTAD, E. (1993). The antiinfiammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. J. Clin. Invest., 92, 2675-2682.
9. CRONSTEIN, B.N., NAIME, D. & FIRESTEIN, G. (1995). The antiinflammatory effects of an adenosine kinase inhibitor are mediated by adenosine. Arthitis Rheum., 38, 1040-1045.
10. 2 purinergic receptors for extracellular ATP and other nucleotides. Am. J. Physiol., 265, C577-C606.
11. EISERICH, J.P., HRISTOVA, M., CROSS, C.E., JONES, A.D., FREEMAN, B.A., HALLIWELL, B. & VAN DER VLIET, A. (1998). Formation of nitric oxide derivatives catalysed by myeloperoxidase in neutrophils. Nature. 391, 393-397.
12. FIRESTEIN, G.S., BOYLE, D., BULLOUGH, D.A., GRUBER, H.E. SAJJADI, F.G., MONTAG, A., SAMBOL, B. & MULLANE, K.M. (1994). Protective effect of an adenosine kinase inhibitor in septic-shock. J. Immunol., 152, 5853-5859.
13. GADANGI, P., LONGAKER, M., NAIME, D., LEVIN, R.L. RECHT, P.A., MONTESINOS, M.C., BUCKLEY, M.T., CARLIN, G. & CRONSTElN, B.N. (1941). The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. J. Immunol., 156, 1937-1941.
14. 3-selective adenosine agonists. J. Med. Chem., 37, 636-646.
15. GERMANN, T., SZELIGA, J., HESS H., STÖRKEL, J., PODLASKI, F.J., GATELY, M.K., SCHMITT, E. & RÜDE, E. (1995). Administration of interleukin 12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc. Natl. Acad. Sci. USA, 92, 4823-4827.
16. HALLIWELL, B. (1997). What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in vivo? FEBS Lett., 411, 157-160.
17. HASKÓ, G. & SZABÓ, C. (1998). Regulation of cytokine and chemokine production by transmitters and co-transmitters of the autonomie nervous system. Biochem. Pharmacol., in press.
18. HASKÓ, G., SZABÓ, C., NÉMETH, Z.H., KVETAN, V., PASTORES, S.M. & VIZI, E.S. (1996). Adenosine receptor agonists differentially regulate IL-10, TNF-α and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J. Immunol., 157, 4634-4640.
19. HASKÓ G., SZABÓ C., NÉMETH Z.H., SALZMAN, A.L. & VIZI, E.S. (1998a). Suppression of interleukin-12 production by phosphodiesterase inhibition in murine endotoxemia is interleukin-10 independent. Eur. J. Immunol., 28, 468-472.
20. HASKÓ G., VIRÁG L., EGNACZYK G., SALZMAN, A.L. & SZABÓ, C. (1998b). The crucial role of IL-10 in the suppression of the immunological response in mice exposed to staphylococcal enterotoxin B. Eur. J. Immunol., 28, 1417-1425.
21. JOOSTEN, L.A.B., LUBBERTS, E., HELSEN, M.M.A. & VAN DEN BERG, W.B. (1997). Dual role of IL-12 in early and late stages of murine collagen type II arthritis. J. Immunol., 159, 4094-4102.
22. KASAMA T., STRIETER, R.M., LUKACS N.W., LINCOLN, P.M., BURDICK, P.D. & KUNKEL, S.L. (1995). Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. J. Clin. Invest., 95, 2868-2876.
23. KAUR, H. & HALLlWELL, B. (1994). Evidence for nitric oxide-mediated oxidative damage in chronic inflammation, Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett., 350, 9-12.
24. KUNKEL, S.L., LUKACS, N., KASAMA, T. & STRIETER, R.M. (1996). The role of chemokines in inflammatory joint disease. J. Leukocyte Biol., 59, 6-12.
25. LE MOINE, O., STORDEUR, P., SCHANDENÉ, L., MARCHANT, A., DE GROOTE, D., GOLDMAN, M. & DEVIERE, J. (1996). Adenosine enhances IL-10 secretion by human monocytes. J. Immunol., 156, 4408-4414.
26. LE VRAUX, V., CHEN, Y.L., MASSON, I., DE SOUSA, M., GIROUD, J.P., FLORENTIN, I. & CHAUVELOT-MOACHON, L. (1993). Inhibition of human monocyte TNF production by adenosine receptor agonists. Life Sci., 52, 1917-1924.
27. MARTIN, C.A. & DORF, M.E. (1991). Differential regulation of interleukin-6, macrophage inflammatory protein-1, and JE/ MCP-1 cytokine expression in macrophage cell lines. Cell Immunol., 135, 245-258.
28. MCCARTNEY-FRANCIS, N., ALLEN, J.B., MIZEL, D.E., ALBINA, J.E. XIE, Q.W., NATHAN, C.F. & WAHL, S.M. (1994). Suppression of arthritis by an inhibitor of nitric oxide synthase. J. Exp. Med., 178, 749-754.
29. MCINTYRE, M., SHUSTER, D.J., GILLOOLY, K.M., WARRIER, R.R., CONNAUGHTON, S.E., HALL, L.B., ARP, L.H., GATELY, M.K. & MAGRAM, J. ( 1996). Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deticient mice. Eur. J. Immunol., 26, 2933-2938.
30. MCWHINNEY, C.D., DUDLEY, M.W., BOWLIN, T.L., PEET, N.P., SCHOOK, L., BRADSHAW, M., DE, M., BORCHERDING, D.R. & EDWARDS, C.K. (1996). C.K. III Activation of adenosine A, receptors on macrophages inhibits tumor necrosis factor-α. Eur. J. Pharmacol., 310, 209-216.
31. RICHES, D.W., WATKINS, J.L., HENSON, P.M. & STANWORTH, D.R. (1985). Regulation of macrophage lysosomal secretion by adenosine, adenosine phosphate esters, and related structural analogues of adenosine. J. Leukoc. Biol., 37, 545-557.
32. SAJJADI, E.G., TABAYASHI, K . FOSTER, A.C., DOMINGO, R.C. & FTRESTEIN, G.S. (1996). Inhibition of TNF-α expression by adenosine. Role of A3 adenosine receptors. J. Immunol., 156, 3435-3442.
33. SHANLEY, T,P., SCHMAL, H., FRIEDL, H.P., JONES, M.L. & WARD, P.A. (1995). Role of macrophage inflammatory protein-1 alpha in acute lung injury in rats. J. Immunol., 154, 4793-4802.
34. STANDIFORD, T.J., KUNKEL, S.L., LUKACS, N.W., GREENBERGER, M.J., DANFORTH, J.M., KUNKEL, R.G. & STRIETER, R.M. (1995). Macrophage inflammatory protein-1 alpha mediates lung leukocyte recruitment, lung capillary leak, and early mortality in murine endotoxemia. J. Immunol., 155, 1515-1524.
35. SZABO, C., LIM, L.H., CUZZOCREA, S., GETTING, S.J., ZINGARELLI, B., FLOWER, R.J., SALZMAN, A.L. & PERRETTI, M. (1997). Inhibition of poly (ADP-ribose) synthetase exerts anti-inflammatory effects and inhibits neutrophil recruitment. J. Exp. Med., 186, 1041-1049.
36. SZABO, C, VIRAG, L, CUZZOCREA, S., SCOTT, G.J., HAKE, P., O'CONNOR, M.P., ZINGARELLI, B., SALZMAN, A.L. & KUN, E. (1998). Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly (ADP-ribose) synthetase. Proc. Natl. Acad. Sci. USA. 95, 3867-3872.
37. TRACEY, W.R., MAGEE, W., MASAMUNE, H., KENNEDY, S.P., KNIGHT, D.R., BUCHHOLZ, R.A & HILL, RJ. (1997). Selective adenosine A3 receptor stimulation reduces ischemic myocardial injury in the rabbit heart. Cardiovasc. Res., 33, 410-415.
38. VON LUBITZ, D.K., LIN, R.C., POPIK, P., CARTER, M.F. & JACOBSON, K.A. (1994). Adenosine A3 receptor stimulation and cerebral ischemia. Eur. J. Pharmacol., 263, 59-67.
39. WOLBERG, G. & ZIMMERMAN, T.P. (1985). Effects of adenosine deaminase inhibitors on lymphocyte-mediated cytolysis. Ann. N. Y. Acad. Sci., 451, 215-226.