Adenosine A(2A) receptors mediate the inhibitory effect of adenosine on formyl-Met-Leu-Phe-stimulated respiratory burst in neutrophil leucocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 354, Issue 3, 1996, Pages 262-267

  Fredholm, Bertil B ^a   Zhang, Yu ^a   Van Der Ploeg, Ingeborg ^b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adenosine analogues; Adenosine receptors; Caffeine; Cyclic AMP; Theophylline

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 AMINO 8 CHLORO 1 PHENYL 1,2,4 TRIAZOLO[4,3 A]QUINOXALINE; 8 (3 CHLOROSTYRYL)CAFFEINE; 8 (3,4 DIMETHOXYSTYRYL) 7 METHYL 1,3 DIPROPYLXANTHINE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5,6 DIHYDRO 5 IMINO 1,2,4 TRIAZOLO[2,3 C]QUINAZOLINE; ADENOSINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE A2 RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; CAFFEINE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; MESSENGER RNA; PARAXANTHINE; RECEPTOR SUBTYPE; THEOPHYLLINE; 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE; 2 ANILINOADENOSINE; 2-PHENYLAMINOADENOSINE; 9 CHLORO 2 (2 FURYL) (1,2,4)TRIAZOLO(1,5 C)QUINAZOLIN 5 IMINE; 9-CHLORO-2-(2-FURYL)-(1,2,4)TRIAZOLO(1,5-C)QUINAZOLIN-5-IMINE; ADENOSINE RECEPTOR; CARDIOVASCULAR AGENT; DRUG DERIVATIVE; HYDROGEN PEROXIDE; PHENETHYLAMINE DERIVATIVE; QUINAZOLINE DERIVATIVE; TRIAZOLE DERIVATIVE; XANTHINE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKOCYTE ACTIVATION; NEUTROPHIL; NORMAL HUMAN; RESPIRATORY BURST; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANALYSIS OF VARIANCE; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSCRIPTION; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ADENOSINE; ANALYSIS OF VARIANCE; CARDIOVASCULAR AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN PEROXIDE; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NEUTROPHILS; PHENETHYLAMINES; POLYMERASE CHAIN REACTION; QUINAZOLINES; RECEPTORS, PURINERGIC P1; RESPIRATORY BURST; TRANSCRIPTION, GENETIC; TRIAZOLES; XANTHINES;

EID: 0029658634     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00171056     Document Type: Article

References (41)

1. Arnaud MJ (1993) Metabolism of caffeine and other components of coffee. In: Garattini S (ed) Caffeine, coffee and health. Raven Press, New York, pp 43-95
2. Bokoch GM, Quilliam LA, Bohl BP, Jesaitis AJ, Quinn MT (1991) Inhibition of Rap1A binding to cytochrome b558 of NADPH oxidase by phosphorylation of Rap1A. Science 254:1794-1796
3. 2b adenosine receptor in NIH 3T3 fibroblasts. Biochem Pharmacol 47:801-814
4. 3H]-NECA in rat striatal membranes. Mol Pharmacol 29:331-346
5. Burkey TH, Webster RO (1993) Adenosine inhibits fMLP-stimulated adherence and superoxide anion generation by human neutrophils at an early step in signal transduction. Biochim Biophys Acta 1175:312-318
6. Capecchi PL, Ceccatelli L, Beermann U, Laghi Pasini F, Di Perri T (1993) Inhibition of neutrophil function in vitro by nimesulide. Preliminary evidence of an adenosine-mediated mechanism. Arzneimittelforschung 43:992-996
7. Cronstein BN (1994) Adenosine, an endogenous anti-inflammatory agent. J Appl Physiol 76:5-13
8. 2 generation, respectively. J Clin Invest 85:1150-1157
9. Cronstein BN, Haines KA, Kolasinski S, Reibman J (1992) Occupancy of G alpha s-linked receptors uncouples chemoattractant receptors from their stimulus-transduction mechanisms in the neu-trophil. Blood 80:1052-1057
10. Cronstein BN, Naime D, Ostad E (1993) The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. J Clin Invest 92:2675-2682
11. Daly JW, Jacobson KA (1995) Adenosine receptors: selective agonists and antagonists. In: Belardinelli L, Pelleg A (eds) Adenosine and adenine nucleotides: from molecular biology to integrative physiology. Kluwer. Boston, pp 157-166
12. 2 dopumine receptors in rat striatum. Brain Res Mol Brain Res 14:186-195
13. Fredholm BB (1995) Purinoceptors in the nervous system. Pharmacol Toxicol 76:228-239
14. Fredholm BB, Abbracchio MP, Burnstock G, Daly JW, Harden TK, Jacobson KA, Leff P, Williams M (1994) Nomenclature and classification of purinoceptors. Pharmacol Rev 46:143-156
15. 2 receptor. Brain Res Mol Brain Res 15:62-66
16. Gunther GR, Herring MB (1991) Inhibition of neutrophil superoxide production by adenosine released from vascular endothelial cells. Ann Vase Surg 5:325-330
17. Gurden MF, Coates J, Ellis F, Evans B, Foster M, Hornby E, Kennedy I, Martin DP, Strong P, Vardey CJ (1993) Functional characterization of three adenosine receptor types. Br J Pharmacol 109:693-698
18. 2A adenosine receptors from rat striatum and rat pheochromocytoma PC12 cells: characterization with radioligand binding and by activation of adenylate cyclase. Mol Pharmacol 41:352-359
19. 2-adenosine antagonist in vitro and in vivo. FEBS Lett 323:141-144
20. Kochanek PM, Hallenbeck JM (1992) Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke. Stroke 23:1367-1379
21. 2A receptors. Pharmacol Toxicol 76 (Suppl II):P1.26
22. Musgrave IF, Genieser HG, Maronde E, Seifert R (1993) Preparations of Rp-cyclic adenosine 3′,5′-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. FEBS Lett 318:227-230
23. Nielson CP, Crowley JJ, Morgan ME, Vestal RE (1988) Polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3′,5′-adenosine monophosphate. Am Rev Respir Dis 137:25-30
24. Nolle D, Lehr HA, Messmer K (1991) Adenosine inhibits postischemic leukocyte-endothelium interaction in postcapillary venules of the hamster. Am J Physiol 261:H651-H655
25. 2 receptor. Naunyn-Schmiedeberg's Arch Pharmacol 346:234-237
26. 2 receptor antagonist. Eur J Pharmacol (Mol Phamiacol) 267:335-341
27. 2b receptors from human brain. Biochem Biophys Res Commun 187:86-93
28. Rudolphi KA, Schubert P, Parkinson FE, Fredholm BB (1992) Neuroprotective role of adenosine in cerebral ischaemia. Trends Phamiacol Sci 13:439-445
29. Sarges R, Howard HR, Browne RG, Lebel LA, Seymour PA, Koe BK (1990) 4-Amino(1,2,4)triazolo(4,3-a)quinoxalines. A novel class of potent adenosine receptor antagonists and potential rapidonset antidepressants. J Med Chem 33:2240-2254
30. Schmeichel CJ, Thomas LL (1987) Methylxanthine bronchodilators potentiate multiple human neutrophil functions. J Immunol 138:1896-1903
31. Schwartz LM, Raschke P, Becker BF, Gerlach E (1993) Adenosine contributes to neutrophil-mediated loss of myocardial function in post-ischemic guinea-pig hearts. J Mol Cell Cardiol 25:927-938
32. 2 antagonists. J Med Chem 35:2342-2345
33. 2-adenosine receptor subtype. Mol Endocriiiol 6:384-393
34. Toombs CF, McGee S, Johnston WE, Vinten-Johansen J (1992) Myocardial protective effects of adenosine. Infarct size reduction with pretreatment and continued receptor stimulation during ischemia. Circulation 86:986-994
35. 2 receptors. Cell Signal 4:543-551
36. Walker BA, Hagenlocker BE, Douglas VK, Ward PA (1990) Effects of adenosine on inositol 1,4,5-trisphosphate formation and intracellular calcium changes in formyl-Met-Leu-Phe-stimulated human neutrophils. J Leukoc Biol 48:281-283
37. Williams M, Francis J, Ghai G, Braunwalder A, Psychoyos S, Stone GA, Cash WD (1987) Biochemical characterization of the triazoloquinazoline, CGS 15943, a novel, non-xanthine adenosine antagonist. J Pharmacol Exp Ther 241:415-420
38. 2 receptors, adenosine inhibits the upregulation of Mac-1 (Cd11b/CD18) expression on FMLP-stimulated neutrophils. Am J Respir Cell Mol Biol 9:179-185
39. Wright DG (1988) Human neutrophils degranulation. Meth Enzymol 162:538-543
40. 2 produced by human neutrophils during the respiratory burst. Anal Biochem 165:371-378
41. Zhang Y, Fredholm BB (1994) Propentofylline enhancement of the actions of adenosine on neutrophil leukocytes. Biochem Pharmacol 48:2025-2032