An agonist of adenosine A3 receptors decreases interleukin-12 and interferon-γ production and prevents lethality in endotoxemic mice

European Journal of Pharmacology

Volumn 358, Issue 3, 1998, Pages 261-268

  Haskó, György ^a,b   Németh, Zoltán H ^b   Vizi, E Sylvester ^b   Salzman, Andrew L ^c   Szabó, Csaba ^c  

^a INOTEK CORPORATION   (United States)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Cytokine; Inflammation; Inflammatory mediator; Lipopolysaccharide; Nitric oxide (NO); Shock

Indexed keywords

6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; ADENOSINE A3 RECEPTOR; ADENOSINE RECEPTOR STIMULATING AGENT; BACTERIUM LIPOPOLYSACCHARIDE; CORTICOSTERONE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; NITRATE; NITRIC OXIDE; NITRITE; TUMOR NECROSIS FACTOR ALPHA; ADENOSINE; ADENOSINE RECEPTOR; BACTERIAL POLYSACCHARIDE; DRUG DERIVATIVE; ENDOTOXIN; INTERLEUKIN 1; N(6) (3 IODOBENZYL) 5' N METHYLCARBOXAMIDOADENOSINE; N(6)-(3-IODOBENZYL)-5'-N-METHYLCARBOXAMIDOADENOSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTOXEMIA; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; LETHALITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; ANIMAL; BAGG ALBINO MOUSE; BLOOD; C57BL MOUSE; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; GENETICS; MORTALITY; SPECIES DIFFERENCE; SURVIVAL;

ADENOSINE; ANIMALS; CORTICOSTERONE; ENDOTOXEMIA; ENDOTOXINS; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NITRATES; NITRITES; POLYSACCHARIDES, BACTERIAL; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; SPECIES SPECIFICITY; SURVIVAL ANALYSIS;

EID: 0032500375     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00619-0     Document Type: Article

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