Apoptosis: A two-edged sword in aging

Annals of the New York Academy of Sciences

Volumn 887, Issue , 1999, Pages 1-11

  Warner, Huber R ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REACTIVE OXYGEN METABOLITE;

AGING; APOPTOSIS; AUTOIMMUNITY; CANCER; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; DNA REPAIR; HUMAN; MAMMAL; MITOCHONDRION; MITOSIS; MOLECULAR BIOLOGY; NERVE DEGENERATION; NONHUMAN; OSTEOPOROSIS; RETINA DEGENERATION; TRANSGENE;

MAMMALIA;

EID: 0033391878     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07917.x     Document Type: Conference Paper

References (70)

1. 1. Columbano, A. 1995. Cell death: Current difficulties in discriminating apoptosis from necrosis in the context of pathological processes in vivo. J. Cell. Biochem. 58: 181-190.
2. 2. Kerr, J.F.R., A.H. Wyllie & A.R. Currie. 1972. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26: 239-257.
3. 3. Raff, M. 1998. Cell suicide for beginners. Nature 396: 119-122.
4. 4. Nagata, S. & P. Golstein. 1995. The Fas death factor. Science 267: 1449-1456.
5. 5. Ogawa, N., H. Dang & N. Talal. 1995. Apoptosis and autoimmunity. J. Autoimmun. 8: 1-19.
6. 6. Thompson, C.B. 1995. Apoptosis in the pathogenesis and treatment of disease. Science 267: 1456-1462.
7. 7. Vaux, D.L., S. Cory & J.H. Adams. 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335: 440-442.
8. 8. Williams, G.T. 1991. Programmed cell death: Apoptosis and ontogenesis. Cell 65: 1097-1098.
9. 9. Warner, H.R., R.J. Hodes & K. Pocinki. 1997. What does cell death have to do with aging? J. Am. Ger. Soc. 45: 1140-1146.
10. 10. Ellis, R.E., J. Yuan & H.R. Horvitz. 1991. Mechanisms and functions of cell death. Ann. Rev. Cell Biol. 7: 663-698.
11. 11. Adams, J.M. & S. Corey. 1998. The Bcl-2 protein family: Arbiters of cell survival. Science 281: 1322-1326.
12. 12. Thornberry, N.A. & Y. Lazebnik. 1998. Caspases: enemies within. Science 281: 1312-1316.
13. 13. Clem, R.J., E.H.-Y. Cheng, C.L. Karp, D.G. Kirsch, K. Ueno, A. Takahashi, M.B. Kastan, D.E. Griffin, W.C. Earnshaw, M.A. Veliuona & J.M. Hardwick. 1998. Modulation of cell death by Bcl-XL through caspase interaction. Proc. Natl. Acad. Sci. USA 95: 554-559.
14. 14. Fattman, C.L., B. An & Q.P. Dou. 1997. Characterization of interior cleavage of retinoblastoma protein in apoptosis. J. Cell. Biochem. 67: 399-408.
15. 15. Tewari, M., L.T. Quan, K. O'Rourke, S. Desnoyers, Z. Zeng, D.R. Beidler, G.G. Poirier, G.S. Salvesan & V.M. Dixit. 1995. Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly (ADP-ribose) polymerase. Cell 81: 801-809.
16. 16. Takahashi, H., E.S. Alnemri, Y.A. Lazebnik, T. Fernandes-Alnemri, G. Litwack, R.D. Moir, R.D. Goldman, G.G. Poirier, S.H. Kaufmann & W.C. Earnshaw. 1996. Cleavage of lamin A by Mch2α but not CPP32: Multiple interleukin 1β-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis. Proc. Natl. Acad. Sci. USA 93: 8395-8400.
17. 17. Kayalar, C., T. Örd, M.P. Testa, L.-T. Zhong & D.E. Bredesen. 1996. Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition. Proc. Natl. Acad. Sci. USA 93: 2234-2238.
18. 18. Liu, X., H. Zou, C. Slaughter & X. Wang. 1997. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 89: 175-184.
19. 19. Enari, M., H. Sakahira, H. Yokoyama, K. Okawa, A. Iwamatsu & S. Nagata. 1998. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature 391: 43-50.
20. 20. Levine, A.J. 1997. p53, the cellular gatekeeper for growth and division. Cell 88: 323-331.
21. 21. Weindruch, R. 1989. Dietary restriction, tumors, and aging in rodents. J. Gerontol. 44: 67-71.
22. 22. Grasl-Kraupp, B., W. Bursch, B. Ruttkay-Nedecky, A. Wagner, B. Lauer & R. Schulte-Hermann. 1994. Food restriction eliminates preneoplastic cells through apoptosis and antagonizes carcinogenesis in rat liver. Proc. Natl. Acad. Sci. USA 91: 9995-9999.
23. 23. James, S.J. & L. Muskhelishvili. 1994. Rates of apoptosis and proliferation vary with caloric intake and may influence incidence of spontaneous hepatoma in C57BL/ 6×C3HFI mice. Cancer Res. 54: 5508-5510.
24. 24. Holt, P.R., S.F. Moss, A.R. Heydari & A. Richardson. 1998. Diet restriction increases apoptosis in the gut of aging rats. J. Gerontol. 53A: B168-B172.
25. 25. Warner, H.R., G. Fernandes & E. Wang. 1995. A unifying hypothesis to explain the retardation of aging and tumorigenesis by caloric restriction. J. Gerontol. 50A: B107-B109.
26. 26. Dimri, G.P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E.E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacocke & J. Campisi. 1995. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92: 9363-9367.
27. 27. Wang, E. 1995. Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl-2 is involved. Cancer Res. 55: 2284-2292.
28. 28. Wang, E., M.J. Lee & S. Pandey. 1994. Control of fibroblast senescence and activation of programmed cell death. J. Cell. Biochem. 54: 432-439.
29. 29. Millis, A.J., M. Hoyle, H.M. McCue & H. Martini. 1992. Differential expression of metalloproteinase and tissue inhibitor of metalloproteinase genes in aged human fibroblasts. Exp. Cell Res. 201: 373-379.
30. 30. Campisi, J. 1997. Aging and cancer: the double edged sword of replicative senescence. J. Am. Ger. Soc. 45: 482-488.
31. 31. Masson, R., O. Lefebvre, A. Noël, M. El Fahime, M.P. Chenard, C. Wendling, F. Kebers, M. LeMeur, A. Dierich, J.M. Foidart, P. Basset & M.C. Rio. 1998. In vivo evidence that stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy. J. Cell Biol. 140: 1535-1541.
32. 32. Jacobson, M.D., M. Weil & M.C. Raff. 1997. Programmed cell death in animal development. Cell 88: 347-354.
33. 33. Watanabe-Fukunaga, R., C.I. Brannan, N.G. Copeland, N.A. Jenkins & S. Nagata. 1992. Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis. Nature 356: 314-317.
34. 34. Takahaski, T., M. Tanaka, C.I. Brannan, N.A. Jenkins, N.G. Copeland, T. Suda & S. Nagata. 1994. Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand. Cell 76: 969-976.
35. 35. Luan, X., W. Zhao, B. Chandrasekar & G. Fernandes. 1995. Calorie restriction modulates lymphocyte subset phenotype and increases apoptosis in MRL/lpr mice. Immunol. Lett. 47: 181-186.
36. 36. Rieux-Laucat, F., F. Le Deist, C. Hivroz, I.A.G. Roberts, K.M. Debatin, A. Fischer & J.P. DeVillartay. 1995. Mutations in Fas associated with human lymphoproliferative syndrome and autoimmunity. Science 268: 1347-1349.
37. 37. Fisher, G.H., F.J. Rosenberg, S.E. Straus, J.K. Dale, L.A. Middeton, A.Y. Lin, W. Strober, M.J. Lenardo & J.M. Puck. 1995. Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome. Cell 81: 935-946.
38. 38. Aringer, M., W. Wintersberger, C.W. Steiner, H. Kiener, E. Presterl, U. Jaeger, J.S. Smolen & W.B. Graninger. 1994. High levels of bcl-2 protein in circulating T-lymphocytes, but not B-lymphocytes, of patients with systemic lupus erythematosus. Arthritis Rheum. 37: 1423-1430.
39. 39. Zhou, T., C.K. Edwards & J.D. Mountz. 1995. Prevention of age-related T cell apoptosis defect in CD2-fas-transgenic mice. J. Exp. Med. 182: 129-137.
40. 40. Hughes, D.E., A. Dai, J.C. Tiffee, H.H. Li, G.R. Mundy & B.F. Boyce. 1996. Estrogen promotes apoptosis of murine osteoclasts mediated by TGF-β. Nature Med. 2: 1132-1136.
41. 41. Okahashi, N., M. Koide, E. Jimi, T. Suda & T. Nishihara. 1998. Caspases (interleukin-1β-converting enzyme family proteases) are involved in the regulation of the survival of osteoclasts. Bone 23: 33-41.
42. 42. Rogers, M.J., K.M. Chilton, F.P. Coxom, J. Lawry, M.O. Smith, S. Suri & R.G. Russell. 1996. Bisphosphonates induce apoptosis in mouse macrophage-like cells in vitro by a nitric oxide-independent mechanism. J. Bone Mineral Res. 11: 1482-1491.
43. 43. Yan, L.-J. R.L. Levine & R.S. Sohal. 1997. Oxidative damage during aging targets mitochondrial aconitase. Proc. Natl. Acad. Sci. USA 94: 11168-11172.
44. 44. Yan, L.-J. & R.S. Sohal. 1998. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc. Natl. Acad. Sci. USA 95: 12896-12901.
45. 45. Graham, B.H., K.G. Waymire, B. Cottrell, I.A. Trounce, G.R. MacGregor & D.C. Wallace. 1997. A mouse model for mitochondrial myopathy and cardiomyopathy resulting from a deficiency in the heart/muscle isoform of the adenine nucleotide translocator. Nature Genetics 16: 226-234.
46. 46. Nieminen, A.-L, A.K. Saylor, S.A. Tesfai, B. Herman & J.J. Lemasters. 1995. Contribution of the mitochondrial permeability transition to lethal injury after exposure of hepatocytes to t-butylhydroperoxide. Biochem. J. 307: 99-106.
47. 47. Yang, J., X. Liu, K. Bhalla, C.N. Kim, A.M. Ibrado, J. Cai, T.I. Peng, D.P. Jones & X. Wang. 1997. Prevention of apoptosis by bcl-2: Release of cytochrome c from mitochondria blocked. Science 275: 1129-1132.
48. 48. Green, D.R. & J.C. Reed. 1998. Mitochondria and apoptosis. Science 281: 1309-1312.
49. 49. Smale, G., N.R. Nicholas, D.R. Brady, C.E. Finch & W.E. Horton, JR. 1995. Evidence for apoptotic cell death in Alzheimer's disease. Exp. Neurol. 133: 225-230.
50. 50. Cotman, C.W. & A.J. Anderson. 1995. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10: 19-45.
51. 51. Dragunow, M., R.L. Faull, P. Lawlor, E.J. Beilharz, K. Singleton, E.B. Walker & E. Mee. 1995. In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport 9: 1053-1057.
52. 52. Thomas, L.B., D.J. Gates, E.K. Richfield, T.F. O'Brien, J.B. Schweitzer & D.A. Steinder. 1995. DNA end labelling (TUNEL) in Huntington's disease and other neuropathological conditions. Exp. Neurol. 133: 265-272.
53. 53. Kostic, V., V. Jackson-Lewis, F. De Bilbao, M. Dubois-Dauphin & S. Przedborski. 1997. Bcl-2: prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 277: 559-562.
54. 54. Friedlander, R.M., R.H. Brown, V. Gagliardini, J. Wang & J. Yuan. 1997. Inhibition of ICE slows ALS in mice. Nature 388: 31.
55. 55. Hara, H., R.M. Friedlander, V. Gagliardini, C. Ayata, K. Fink, Z. Huang, M. Shimtzu-Sasamata, J. Yuan & M.A. Moskowitz. 1997. Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc. Natl. Acad. Sci. USA 94: 2007-2012.
56. 56. Milligan, C.E., D. Prevette, H. Yaginuma, S. Homma, C. Cardwell, L.C. Fritz, K.J. Tomaselli, R.W. Oppenheim & L.M. Schwartz. 1995. Peptide inhibitors of the ICE protease family arrest programmed cell death of neurons in vivo and in vitro. Neuron 15: 385-393.
57. 57. Friedlander, R.M., V. Gagliardini, V., H. Hara, K.B. Fink, W. Li, G. Mac Donald, M.C. Fishman, A.H. Greenberg, M.A. Moskowitz & J. Yuan. 1997. Expression of a dominant negative mutant of interleukin-1β converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J. Exp. Med. 185: 933-940.
58. 58. Barinaga, M. 1998. Stroke-damaged neurons may commit cellular suicide. Science 281: 1302-1303.
59. 59. Barinaga, M. 1998. Is apoptosis key in Alzheimer's disease? Science 281: 1303-1304.
60. 60. Yang, G., P.H. Chan, J. Chen, E. Carlson, S.F. Chen, P. Weinstein, C.J. Epstein & H. Kamii. 1994. Human copper-zinc superoxide dismutase transgenic mice are highly resistant to reperfusion injury after focal cerebral ischemia. Stroke 25: 165-170.
61. 61. Parkes, T.L., A.J. Elia, D. Dickinson, A.J. Hilliker, J.P. Phillips & G.L. Boulianne. 1998. Extension of Drosophila lifespan by overepression of human SOD1 in motorneurons. Nature Genetics 19: 171-174.
62. 62. Travis, G.H. 1998. Mechanisms of cell death in inherited retinal degeneration. Am. J. Hum. Genet. 62: 503-508.
63. 63. Humphries, M.M., D. Rancourt, G.J. Farrar, P. Kenna, M. Hazel, R.A. Bush, P.A. Sieving, D.M. Shiels, N. McNally, P. Creighton, A. Erven, A. Boros, K. Gulya, M.R. Capecchi & P. Humphries. 1997. Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nature Genet. 15: 216-219.
64. 64. Davidson, F.F. & H. Steller. 1998. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants. Nature 391: 587-591.
65. 65. Li, Y., T.-T. Huang, E.J. Carlson, S. Melov, P.C, Ursell, J.L. Olson, L.J. Noble, M.P. Yoshimura, C. Berger, P.H. Chan, D.C. Wallace & C.J. Epstein. 1995. Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11: 376-381.
66. 66. Lebovitz, R.M., H. Zhang, H. Vogel, J. Cartwright, L. Dionne, N. Lu, S. Huang & M.M. Matzuk. 1996. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc. Natl. Acad. Sci. USA 93: 9782-9787.
67. 67. Williams, M.D., H. Van Remmen, C.C. Conrad, T.-T. Huang, C.J. Epstein & A. Richardson. 1998. Increased oxidative damage is correlated to altered mitochondrial function in heterozygous manganese superoxide dismutase knockout mice. J. Biol. Chem. 273: 28510-28515.
68. 68. Saraste, A., K. Pulkki, M. Kallajoki, K. Hendriksen, M. Parvinen & L.M. Voipio-Pulkki. 1997. Apoptosis in human acute myocardial infarction. Circulation 95: 320-323.
69. 69. Kajstura, J., W. Cheng, K. Reiss, W.A. Clark, E.H. Sonnenblick, S. Krajewski, J.C. Reed, G. Olivetti & P. Anversa. 1996. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab. Invest. 74: 86-107.
70. 70. Lee, C.M., S.S. Chung, J.M. Kaczkowski, R. Weindruch & J.M. Aiken. 1993. Multiple mitochondrial DNA deletions associated with age in skeletal muscle of rhesus monkeys. J. Gerontology 48: B201-B205.