Activation of β-globin promoter by eythroid Kruppel-like factor

Molecular and Cellular Biology

Volumn 18, Issue 1, 1998, Pages 102-109

  Asano, Haruhiko ^a   Stamatoyannopoulos, George ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GLOBIN; ERYTHROID KRUPPEL LIKE FACTOR;

ANIMAL CELL; ARTICLE; CELL STRAIN K 562; GENE ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION;

ANIMALIA;

EID: 0031962279     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/mcb.18.1.102     Document Type: Article

References (38)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1994. Current protocols in molecular biology. John Wiley & Sons, Inc., New York, N.Y.
2. Bieker, J. J. 1995. Role of erythroid Krüppel-like factor (EKLF) in erythroid-specific transcription, p. 231-241. In G. Stamatoyannopoulos (ed.), Molecular biology of hemoglobin switching. Intercept. Andover, United Kingdom.
3. Bieker, J. J., and C. M. Southwood. 1995. The erythroid Krüppel-like factor transactivation domain is a critical component for cell-specific inducibility of a β-globin promoter. Mol. Cell. Biol. 15:852-860.
4. Catala, F., E. deBoer, G. Habets, and F. Grosveld. 1989. Nuclear protein factors and erythroid transcription of the human Aγ-globin gene. Nucleic Acids Res. 17:3811-3827.
5. Chen, X., and J. J. Bieker. 1996. Erythroid Krüppel-like factor (EKLF) contains a multifunctional transcriptional activation domain important for inter- and intramolecular interactions. EMBO J. 15:5888-5896.
6. Donze, D., T. M. Townes, and J. J. Bieker. 1995. Role of erythroid Kruppel-like factor in human γ-to β-globin gene switching. J. Biol. Chem. 270:1955-1959.
7. Evans, T., G. Felsenfeld, and M. Reitman. 1990. Control of globin gene transcription. Annu. Rev. Cell Biol. 6:95-124.
8. Feng, W. C., C. M. Southwood, and J. J. Bieker. 1994. Analyses of β-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor. J. Biol. Chem. 269: 1493-1500.
9. Gumucio, D. L., K. L. Rood, K. L. Blanchard-McQuate, T. A. Gray, A. Saulino, and F. S. Collins. 1991. Interaction of Sp1 with the human γ globin promoter: binding and transactivation of normal and mutant promoters. Blood 78:1853-1863.
10. Hartzog, G. A., and R. M. Myers. 1993. Discrimination among potential activators of the β-globin CACCC element by correlation of binding and transcriptional properties. Mol. Cell. Biol. 13:44-56.
11. Ikuta, T., T. Papayannopoulou, G. Stamatoyannopoulos, and Y. W. Kan. 1996. Globin gene switching. In vivo protein-DNA interactions of the human β-globin locus in erythroid cells expressing the fetal or the adult globin gene program. J. Biol. Chem. 271:14082-14091.
12. Kadonaga, J. T., K. R. Carner, F. Masiarz, and R. Tjian. 1987. Isolation of cDNA encoding transcription factor Sp1 and functional analysis of the DNA binding domain. Cell 51:1079-1090.
13. Kulozik, A. E., A. Bellan-Koch, S. Bail, E. Kohne, and E. Kleihauer. 1991. Thalassemia intermedia: moderate reduction of β globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element. Blood 77:2054-2058.
14. Lin, H. J., C. Y. Han, and A. W. Nienhuis. 1992. Functional profile of the human fetal γ-globin gene upstream promoter region. Am. J. Hum. Genet. 51:363-370.
15. Luo, X., and M. Sawadogo. 1996. Functional domains of the transcription factor USF2: atypical nuclear localization signals and context-dependent transcriptional activation domains. Mol. Cell. Biol. 16:1367-1375.
16. Miller, I. J., and J. J. Bieker. 1993. A novel, erythroid cell-specific murine transcription factor that hinds to the CACCC element and is related to the Krüppel family of nuclear proteins. Mol. Cell. Biol. 13:2776-2786.
17. Mitchell, P. J., and R. Tjian. 1989. Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteins. Science 245:371-378.
18. Nuez, B., D. Michalovich, A. Bygrave, R. Ploemacher, and F. Grosveld. 1995. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature (London) 375:316-318.
19. Orkin, S. H. 1995. Transcriptional factors and hematopoietic development. J. Biol. Chem. 270:4955-4958.
20. Orkin, S. H., S. E. Antonarakis, H. H. Kazazian, Jr. 1984. Base substitution at position -88 in a β-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC. J. Biol. Chem. 259:8679-8681.
21. Orkin, S. H., H. H. Kazazian, Jr., S. E. Antonarakis, S. C. Goff, C. D. Boehm, J. P. Sexton, P. G. Waber, and P. J. V. Giardina. 1982. Linkage of β-thalassemia mutations and β-globin gene polymorphisms with DNA poly-morphisms in human β-globin gene cluster. Nature (London) 296:627-631.
22. Perkins, A. C., K. M. L. Gaensler, and S. H. Orkin. 1996. Silencing of human fetal globin expression is impaired in the absence of the adult β-glohin gene activator protein EKLF. Proc. Natl. Acad. Sci. USA 93:12267-12271.
23. Perkins, A. C., A. H. Sharpe, and S. H. Orkin. 1995. Lethal β-thalassemia in mice lacking the erythroid CACCC-transcription factor EKLF. Nature (London) 375:318-322.
24. Ptashne, M., and A. Gann. 1997. Transcriptional activation by recruitment. Nature (London) 386:569-577.
25. Seed, B., and J.-Y. Sheen. 1988. A simple phase-extraction assay for chloramphenicol acyltransferase activity. Gene 67:271-277.
26. Southwood, C. M., K. M. Downs, and J. J. Bieker. 1996. Erythroid Krüppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev. Dynam. 206:248-259.
27. Stamatoyannopoulos, G., B. Josephson, J.-W. Zhang, and Q. Li. 1993. Developmental regulation of human γ-globin genes in transgenic mice. Mol. Cell. Biol. 13:7636-7644.
28. Stamatoyannopoulos, G., and A. W. Nienhuis. 1993. Hemoglobin switching, p. 107-154. In G. Stamatoyannopoulos, A. W. Nienhuis, P. Majerus, and H. Varmus (ed.), The moleeular basis of blood diseases. W. B. Saunders, Philadelphia, Pa.
29. Stargell, L. A., and K. Struhl. 1996. Mechanisms of transcriptional activation in vivo: two steps forward. Trends Genet. 12:311-315.
30. Tanaka, M. 1996. Modulation of promoter occupancy by cooperative DNA binding and activation-domain function is a major determinant of transcriptional regulation by activators in vivo. Proc. Natl. Acad. Sci. USA 93:4311-4315.
31. Tanaka, M., J.-S. Lai, and W. Herr. 1992. Promoter-selective activation domains in Oct-1 and Oct-2 direct differential activation of an snRNA and mRNA promoter. Cell 68:755-767.
32. Tjian, R., and T. Maniatis. 1994. Transcriptional activation: a complex puzzle with few easy pieces. Cell 77:5-8.
33. Ulrich, M. J., and T. J. Ley. 1990. Function of normal and mutated γ-globin gene promoters in electroporated K562 erythroleukemia cells. Blood 75: 990-999.
34. van Assendelft, G. B., O. Hanscombe, F. Grosveld, and D. R. Greaves. 1989. The β-globin dominant control region activates homologous and heterologous promoters in a tissue-specific manner. Cell 56:969-977.
35. Weatherall, D. J. 1993. The thalassemias, p. 157-205. in G. Stamatoyannopoulos, A. W. Nienhuis, P. Majerus, and H. Varmus (ed.), The molecular basis of blood diseases. W. B. Saunders, Philadelphia, Pa.
36. Wijgerde, M., J. Gribnau, T. Trimborn, B. Nuez, S. Philipsen, F. Grosveld, and P. Fraser. 1996. The role of EKLF in human β-globin gene competition. Genes Dev. 10:2894-2902.
37. Yu, C.-Y., K. Motamed, J. Chen, A. D. Bailey, and C.-K. J. Shen. 1991. The CACC box upstream of human embryonic ε globin gene binds Sp1 and is a functional promoter element in vitro and in vivo. J. Biol. Chem. 266:8907-8915.
38. Zhou, S. Z., Q. Li, G. Stamatoyannopoulos, and A. Srivastava. 1996. Adeno-associated virus 2-mediated transduction and erythroid cell-specific expression of a human β-globin gene. Gene Ther. 3:223-229.