The mechanism of thioacetamide-induced apoptosis in the L37 albumin- SV40 T-antigen transgenic rat hepatocyte-derived cell line occurs without DNA fragmentation

In Vitro Cellular and Developmental Biology - Animal

Volumn 34, Issue 9, 1998, Pages 685-693

  Bulera, Steven J ^a   Sattler, Carol A ^b   Gast, Wendy L ^b   Heath, Susan ^b   Festerling, Todd A ^a   Pitot, Henry C ^b  

^a PFIZER INC   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Cell culture; Cell death; DNA fragmentation; Liver

Indexed keywords

DNA FRAGMENT; ENDONUCLEASE; GROWTH FACTOR; THIOACETAMIDE; VIRUS T ANTIGEN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL STRUCTURE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTER; LIVER CELL CULTURE; LIVER NECROSIS; NONHUMAN; RAT; SIMIAN VIRUS 40; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0032417839     PISSN: 10712690     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11626-998-0064-3     Document Type: Article

References (16)

1. Afanas'ev, V. N.; Korol', Y. A.; Neliopvich, P. A., et al. Flow cytometry and biochemical analysis of DNA degradation characteristics of two types of cell death. FEBS Lett. 194:347-350; 1986.
2. Barker, E. A.; Smuckler, E. A. Altered microsome function during acute thioacetamide poisoning. Mol. Pharmacol. 8:318-326; 1972.
3. Becker, F. F. Thioacetamide hepatocarcinogenesis. J. Natl. Cancer Inst. 71:553-558; 1983.
4. Becker, V.; Walter, W. The action of thioacetyl compounds on the liver parenchyma in animal experiments on rats. Acta Hepatogastroenterol. 12:129-140; 1965.
5. Brinkley, B. R.; Murphy, P.; Richardson, L. C. Procedure for embedding in situ selected cells cultured in vitro. J. Cell Biol. 35:279-283; 1967.
6. Bulera, S. J.; Haas, M. J.; Sattler, C. A., et al. Cell lines with varied morphologies and hepatocellular characteristics are derived from a single preparation of hepatocytes isolated from alb-SV40 T-antigen transgenic rat livers. Hepatology 25:1192-1203; 1997.
7. Bulera, S. J.; Sattler, C. A.; Pitot, H. C. The translational inhibitor cycloheximide represses growth factor depletion-induced apoptosis in an SV40 transgenic rat liver cell line. Hepatology 23:1591-1601; 1996.
8. Bursch, W.; Paffe, S.; Putz, B., et al. Determination of the length of the histological stages of apoptosis in normal liver and in altered hepatic foci of rats. Carcinogenesis 11:847-853; 1990.
9. Dessau, F.; Jackson, B. Acetamide-induced liver alterations in rats. Lab. Invest. 4:187-197; 1955.
10. Don, M. M.; Ablett, G.; Bishop, C. J., et al. Death of cells by apoptosis following attachment of specifically allergized lymphocytes in vitro. Aust. J. Exp. Biol. Med. Sci. 55:407-417; 1977.
11. Duvall, E.; Wyllie, A. H. Death and the cell. Immunol. Today 7:115-119; 1986.
12. Cohen, G. M.; Sun, X. M.; Snowden, R. T., et al. Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation. Biochem. J. 286:331-334; 1992.
13. Collins, R. J.; Harmon, B. V.; Gobe, G. C., et al. Internucleosomal DNA cleavage should not be the sole criterion for identifying apoptosis. Int. J. Radiat. Biol. 61:451-453; 1992.
14. Corcoran, G. B.; Fix, L.; Jones, D. P., et al. Apoptosis: molecular control point in toxicity. Toxicol. Appl. Pharmacol. 128:169-181; 1994.
15. Faa, G.; Ledda-Columbano, G. M.; Ambu, R., et al. An electron microscopic study of apoptosis induced by cycloheximide in rat liver. Liver 14:270-278; 1992.
16. Fraker, P. J.; King, L. E.; Lill-Elghanian, D., et al. Quantification of apoptotic events in pure and heterogeneous populations of cells using the flow cytometer. In: Methods in cell biology. San Diego: Academic Press; 1995:57-76.