Non-carcinogenicity, but dose-related increase in preneoplastic hepatocellular lesions, in a two-year feeding study of phenobarbital sodium in male F344 rats

Food and Chemical Toxicology

Volumn 37, Issue 8, 1999, Pages 869-879

  Hagiwara, A ^a   Miyata, E ^a,d   Tamano, S ^a   Sano, M ^a,d   Masuda, C ^b   Funae, Y ^b   Ito, N ^c   Fukushima, S ^b   Shirai, T ^d  

^a Daiyukai Research Institute for Medical Science   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NAGOYA CITY UNIVERSITY   (Japan)

^d NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Carcinogenicity study; Dose response; F344 rats; GST P positive foci; Phenobarbital

Indexed keywords

GLUTATHIONE TRANSFERASE; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVITY; FOOD COMPOSITION; HISTOPATHOLOGY; LIVER CELL CARCINOMA; LIVER WEIGHT; MALE; NONHUMAN; RAT; SURVIVAL;

ADMINISTRATION, ORAL; ANIMALS; BODY WEIGHT; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; DIET; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; ENZYMES; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HEMATOLOGIC TESTS; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; ISOENZYMES; LIVER; LIVER NEOPLASMS; MALE; ORGAN SIZE; PHENOBARBITAL; PRECANCEROUS CONDITIONS; RATS; RATS, INBRED F344; SURVIVAL RATE; THYROID HORMONES; TIME FACTORS;

EID: 0032844384     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-6915(99)00072-1     Document Type: Article

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