Endocrine factors modulate the phenobarbital-mediated induction of cytochromes P450 and phase II enzymes in a similar strain-dependent manner

Toxicology and Applied Pharmacology

Volumn 150, Issue 1, 1998, Pages 68-75

  Ganem, Leonardo G ^a   Jefcoate, Colin R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; EPOXIDE HYDROLASE; GLUCURONOSYLTRANSFERASE; PHENOBARBITAL; POLYUNSATURATED FATTY ACID; THIAMAZOLE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ANALYSIS; ENZYME REGULATION; FAT INTAKE; FATTY ACID SYNTHESIS; FEMALE; HORMONE RESPONSE; NONHUMAN; RAT; RISK FACTOR; STRAIN DIFFERENCE; TRANSCRIPTION REGULATION;

ANIMALIA;

EID: 0031863453     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1998.8391     Document Type: Article

References (48)

1. Agrawal, A. K., and Shapiro, B. H. (1996). Phenobarbital induction of hepatic CYP2B1 and CYP2B2: Pretranscriptional and post-transcriptional effects of gender, adult age, and phenobarbital dose. Mol. Pharmacol. 49, 523-531.
2. Cashman, J. R. (1989). 5,6-Epoxyeicosatrienoic acid stimulates growth hormone release in rat anterior pituitary cells. Life Sci. 44, 1387-1393.
3. Christou, M., Wilson, N. M., and Jefcoate, C. R. (1987). Expression and function of three cytochrome P-450 isozymes in rat extrahepatic tissues. Arch. Biochem. Biophys. 258, 519-534.
4. Dunn, T. J., Koleske, A. J., Lindahl, R., and Pitot, H. C. (1989). Phenobarbital-inducible aldehyde dehydrogenase in the rat. J. Biol. Chem. 264, 13057-13065.
5. Gallagher, E. P., Buetler, T. M., Stapleton, P. L., Wang, C., Stahl, D. L., and Eaton, D. L. (1995). The effects of diquat and ciprofibrate on mRNA expression and catalytic activities of hepatic xenobiotic metabolizing and antioxidant enzymes in rat liver. Toxicol. Appl. Pharmacol. 134, 81-91.
6. Gonzalez, F. J., Nebert, D. W., Hardwick, J. P., and Kasper, C. B. (1985). Complete cDNA and protein sequence of a pregnenolone 16 alpha-carbonitrile-induced cytochrome P-450. A representative of a new gene family. J. Biol. Chem. 260, 7435-7441.
7. Hoch, F. L. (1988). Lipids and thyroid hormones. Prog. Lipid Res. 27, 199-270.
8. Hoffman, E. C., Reyes, H., Chu, F. F., Sander, F., Conley, L. H., Brooks, B. A., and Hankinson, O. (1991). Cloning of a factor required for activity of the Ah (dioxin) receptor. Science (Washington, D.C.) 252, 954-958.
9. Honkakoski, P., Moore, R., Gynther, J., and Negishi, M. (1996). Characterization of phenobarbital-inducible mouse Cyp2b10 gene transcription in primary hepatocytes. J. Biol. Chem. 271, 9746-9753.
10. Honkakoski, P., and Negishi, M. (1997). Characterization of a phenobarbital-responsive enhancer module in mouse P450 Cyp2b10 gene. J. Biol. Chem. 272, 14943-14949.
11. Huss, J. M., Wang, S. I., Astrom, A., McQuiddy, P., and Kasper, C. B. (1996). Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif. Proc. Natl. Acad. Sci. USA 93, 4666-4670.
12. Issemann, I., and Green, S. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature 347, 645-650.
13. Kaplowitz, N., Kuhlekamp, J., and Clifton, G. (1975). Drug induction of hepatic glutathione S-transferases in male and female rats. Biochem. J. 146, 351-356.
14. Kostrubsky, V. E., Strom, S. C., Wood, S. G., Wrighton, S. A., Sinclair, P. R., and Sinclair, J. F. (1995). Ethanol and isopentanol increase CYP3A and CYP2E in primary cultures of human hepatocytes. Arch. Biochem. Biophys. 322, 516-520.
15. Kumar, A., Raphael, C., and Adesnik, M. (1983). Cloned cytochrome P-450 cDNA. Nucleotide sequence and homology to multiple phenobarbital-induced mRNA species. J. Biol. Chem. 258, 11280-11284.
16. Laemmli, U. K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680-685.
17. Larsen, M. C., Brake, P. B., Parmar, D., and Jefcoate, C. R. (1994). The induction of five rat hepatic P450 cytochromes by phenobarbital and similarly acting compounds is regulated by a sexually dimorphic, dietary-dependent endocrine factor that is highly strain specific. Arch. Biochem. Biophys. 315, 24-34.
18. Larsen, M. C., and Jefcoate, C. R. (1995). Phenobarbital induction of CYP2B1, CYP2B2, and CYP3A1 in rat liver: Genetic differences in a common regulatory mechanism. Arch. Biochem. Biophys. 321, 467-476.
19. Lim, C. F., Munro, S. L., Wynne, K. N., Topliss, D. J., and Stockigt, J. R. (1995). Influence of nonesterified fatty acids and lysolecithins on thyroxine binding to thyroxine-binding globulin and transthyretin. Thyroid 5, 319-324.
20. Lubet, R. A., Dragnev, K. H., Chauhan, D. P., Nims, R. W., Diwan, B. A., Ward, J. M., Jones, C. R., Rice, J. M., and Miller, M. S. (1992). A pleiotropic response to phenobarbital-type enzyme inducers in the F344/NCr rat. Effects of chemicals of varied structure. Biochem. Pharmacol. 43, 1067-1078.
21. Maltzman, T. H., Christou, M., Gould, M. N., and Jefcoate, C. R. (1991). Effects of monoterpenoids on in vivo DMBA-DNA adduct formation and on phase I hepatic metabolizing enzymes. Carcinogenesis 12, 2081-2087.
22. Maniatis, T., Fritsch, E. F., and Sambrook, J. (1982a). Molecular Cloning: A Laboratory Manual, pp. 7.39-7.52, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
23. Maniatis, T., Fritsch, E. F., and Sambrook, J. (1982b). Molecular Cloning: A Laboratory Manual, pp. 10.59-10.61, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
24. Marshall, W. J., and McLean, A. E. (1971). A requirement for dietary lipids for induction of cytochrome P-450 by phenobarbitone in rat liver microsomal fraction. Biochem. J. 122, 569-573.
25. Mounie, J., Goudonnet, H., Dumas, M., Escousse, A., and Truchot, R. (1981). Nutritional lipidic factors of enzymatic phenobarbital induction in the rat. Effects of quantitative and qualitative composition of dietary lipids. J. Pharmacol. 12, 3-14.
26. Murayama, N., Shimada, M., Yamazoe, Y., and Kato, R. (1991). Difference in the susceptibility of two phenobarbital-inducible forms, P450IIB1 and P450IIB2, to thyroid hormone- and growth hormone-induced suppression in rat liver: Phenobarbital-inducible P450IIB2 suppression by thyroid hormone acting directly, but not through the pituitary system. Mol. Pharmacol. 39, 811-817.
27. Nebert, D. W., Puga, A., and Vasiliou, V. (1993). Role of the Ah receptor and the dioxin-inducible [Ah] gene battery in toxicity, cancer, and signal transduction. Ann. NY Acad. Sci. 685, 624-640.
28. Nuwaysir, E. F., Daggett, D. A., Jordan, V. G., and Pitot, H. C. (1996). Phase II enzyme expression in rat liver in response to the antiestrogen tamoxifen. Cancer Res. 56, 3704-3710.
29. Otto, S., Marcus, C., Pidgeon, C., and Jefcoate, C. (1991). A novel adrenocorticotropin-inducible cytochrome P450 from rat adrenal microsomes catalyzes polycyclic aromatic hydrocarbon metabolism. Endocrinology 129, 970-982.
30. Park, Y., Li, H., and Kemper, B. (1996). Phenobarbital induction mediated by a distal CYP2B2 sequence in rat liver transiently transfected in situ. J. Biol. Chem. 271, 23725-23728.
31. Parkinson, A., Safe, S. H., Robertson, L. W., Thomas, P. E., Ryan, D. E., Reik, L. M., and Levin, W. (1983). Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. J. Biol. Chem. 258, 5967-5976.
32. Perez, F. R., Casabiell, X., Camina, J. P., Zugaza, J. L., and Casanueva, F. F. (1997). Cis-unsaturated free fatty acids block growth hormone and prolactin secretion in thyrotropin-releasing hormone GH3 cells by perturbing the function of plasma membrane intergral proteins. Endocrinology 138, 264-272.
33. Poland, A., Glover, E., and Taylor, B. A. (1987). The murine Ah locus: A new allele and mapping to chromosome 12. Mol. Pharmacol. 32, 471-478.
34. Safe, S. (1990). Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: Environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs). Crit. Rev. Toxicol. 21, 51-88.
35. Schuetz, E. G., Schuetz, J. D., May, B., and Guzelian, P. S. (1990). Regulation of cytochrome P-450b/e and P-450p gene expression by growth hormone in adult rat hepatocytes cultured on a reconstituted basement membrane. J. Biol. Chem. 265, 1188-1192.
36. Schuetz, E. G., Wrighton, S. A., Barwick, J. L., and Guzelian, P. S. (1984). Induction of cytochrome P-450 by glucocorticoids in rat liver. I. Evidence that glucocorticoids and pregnenolone 16 alpha-carbonitrile regulate de novo synthesis of a common form of cytochrome P-450 in cultures of adult rat hepatocytes and in the liver in vivo. J. Biol. Chem. 259, 1999-2006.
37. Sidhu, J. S., and Omiecinski, C. J. (1995). cAMP-associated inhibition of phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocyte cultures. J. Biol. Chem. 270, 12762-12773.
38. Snyder, G. D., Yadagiri, P., and Falck, J. R. (1989). Effect of epoxyeicosatrienoic acids on growth hormone release from somatotrophs. Am. J. Physiol. 256, 221-226.
39. Sommer, R. M., Ramsden, R., Sidhu, J., Costa, P., and Omiecinski, C. J. (1996). Promoter region analysis of the rat CYP2B1 and CYP2B2 genes. Pharmacogenetics 6, 369-374.
40. Tank, A. W., Deitrich, R. A., and Weiner, H. (1986). Effects of induction of rat liver cytosolic aldehyde dehydrogenase on the oxidation of biogenic aldehydes. Biochem. Pharmacol. 35, 4563-4569.
41. Towbin, H., Staehelin, T., and Gordon, J. (1979). Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA 76, 4350-4354.
42. Trottier, E., Belzil, A., Stoltz, C., and Anderson, A. (1995). Localization of a phenobarbital-responsive element (PBRE) in the 5′-flanking region of the rat CYP2B2 gene. Gene 158, 263-268.
43. Venkatraman, J. T., Lefebvre, Y. A., and Clandinin, M. T. (1986). Diet fat alters the structure and function of the nuclear envelope: Modulation of membrane fatty acid composition, NTPase activity and binding of triiodothyronine. Biochem. Biophys. Res. Commun. 135, 655-661.
44. Waxman, D. J., and Azaroff, L. (1992). Phenobarbital induction of cytochrome P-450 gene expression. Biochem. J. 281, 577-592.
45. Waxman, D. J., Sundseth, S. S., Srivastava, P. K., and Lapenson, D. P. (1992). Gene-specific oligonucleotide probes for α, μ, τ, and microsomal rat glutathione S-transferases: Analysis of liver transferase expression and its modulation by hepatic enzyme inducers and platinum anticancer drugs. Cancer Res. 52, 5797-5802.
46. Yaffe, B. M., and Samuels, H. H. (1984). Hormonal regulation of the growth hormone gene. Relationship of the rate of transcription to the level of nuclear thyroid hormone-receptor complexes. J. Biol. Chem. 259, 6284-6291.
47. Yamazoe, Y., Shimada, M., Murayama, N., and Kato, R. (1987). Suppression of levels of phenobarbital-inducible rat liver cytochrome P-450 by pituitary hormone. J. Biol. Chem. 262, 7423-7428.
48. Yamoto, T., Ohashi, Y., Teranishi, M., Takaoka, M., Manabe, S., Matsunuma, N., and Makita, T. (1995). Age-related changes in the susceptibility to clofibric acid, a hypolipidemic agent, of male rat liver. Toxicol. Lett. 78, 141-145.