Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway

Molecular and Cellular Biology

Volumn 21, Issue 10, 2001, Pages 3564-3575

  Wang, G ^a   McCaffery, J M ^a   Wendland, B ^a   Dupre S ^a   Haguenauer Tsapis, R ^a   Huibregtse, J M ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUNGAL PROTEIN; GREEN FLUORESCENT PROTEIN; PROTEIN RSP5P; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOCYTOSIS; ENDOSOME; ENZYME ACTIVITY; GENE DELETION; GENE FUNCTION; GENE LOCATION; GENE MUTATION; GENETIC CODE; IMMUNOGOLD STAINING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SACCHAROMYCES CEREVISIAE;

ENDOCYTOSIS; FUNGAL PROTEINS; GREEN FLUORESCENT PROTEINS; IMMUNOHISTOCHEMISTRY; LIGASES; LUMINESCENT PROTEINS; MUTATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASE COMPLEXES; UBIQUITIN-PROTEIN LIGASES;

SACCHAROMYCES CEREVISIAE; VERTEBRATA;

EID: 0035032224     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.10.3564-3575.2001     Document Type: Article

References (79)

1. The Doa4 deubiquitinating enzyme is functionally linked to the vacuolar protein-sorting and endocytic pathways
2. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosomal function
3. Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae
4. Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast
5. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast
6. The function of the Drosophila Fat facets deubiquitinating enzyme in limiting photoreceptor cell number is intimately associated with endocytosis
7. The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules
8. Chemical synthesis and expression of a cassette adapted ubiquitin gene
9. The yeast multidrug transporter Pdr5 of the plasma membrane is ubiquitinated prior to endocytosis and degradation in the vacuole
10. Rsp5, a ubiquitin-protein ligase, is involved in degradation of the single-stranded DNA binding protein Rfa1 in Saccharomyces cerevisiae
11. The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum
12. A role for ubiquitination in mitochondrial inheritance in Saccharomyces cerevisiae
13. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
14. Ubiquitin lys63 is involved in ubiquitination of a yeast plasma membrane protein
15. Ubiquitination mediated by the Npi1p/Rsp5p ubiquitin-protein ligase is required for endocytosis of the yeast uracil permease
16. VPS21 controls entry of endocytosed and biosynthetic proteins into the yeast prevacuolar compartment
17. A C-terminal di-leucine motif and nearby sequences are required for NH4(+)-induced inactivation and degradation of the general amino acid permease, Gap1p, of Saccharomyces cerevisiae
18. NP11, an essential yeast gene involved in induced degradation of Gap1 and Fur4 permeases, encodes the Rsp5 ubiquitin-protein ligase
19. The ubiquitin system
20. Gettin' down with ubiquitin: Turning off cell-surface receptors, transporters and channels
21. Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins
22. Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis
23. Cytoplasmic tail phosphorylation of the alpha-factor receptor is required for its ubiquitination and internalization
24. Ubiquitin-dependent protein degradation
25. Activation of a membrane-bound transcription factor by regulated ubiquitin/proteasome-dependent processing
26. Catabolite inactivation of the galactose transporter in the yeast Saccharomyces cerevisiae: Ubiquitination, endocytosis, and degradation in the vacuole
27. Structure of an E6AP-UbcH7 complex: Insights into ubiquitination by the E2-E3 enzyme cascade
28. A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase
29. Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins
30. The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase
31. Elimination of defective α-factor pheromone receptors
32. Primary structure of the uracil transport protein of Saccharomyces cerevisiae
33. The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants
34. Catabolite inactivation of the high-affinity hexose transporters Hxt6 and Hxt7 of Saccharomyces cerevisiae occurs in the vacuole after internalization by endocytosis
35. The von Hippel-Lindau tumor suppressor protein is a component of an E3 ubiquitin-protein ligase activity
36. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination
37. Function of WW domains as phosphoserine- or phosphothreonine-binding modules
38. Casein kinase I-dependent phosphorylation within a PEST sequence and ubiquitination at nearby lysines signal endocytosis of yeast uracil permease
39. A PEST-like sequence mediates phosphorylation and efficient ubiquitination of yeast uracil permease
40. The structural era of endocytosis
41. A family of structurally related RING finger proteins interacts specifically with the ubiquitin-conjugating enzyme UbcM4
42. The role of ubiquitin conjugation in glucose-induced proteolysis of Saccharomyces maltose permease
43. The yeast actin-related protein Arp2p is required for the internalization step of endocytosis
44. Exploiting the basis of proline recognition by SH3 and WW domains: Design of N-substituted inhibitors
45. SCF and APC: The Yin and Yang of cell cycle regulated proteolysis
46. Targeting of substrates to the 26S proteasome
47. The C2 domain of the ubiquitin protein ligase Nedd4 mediates Ca2+-dependent plasma membrane localization
48. End3 and end4: Two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae
49. Multilamellar endosome-like compartment accumulates in the yeast vps28 vacuolar protein sorting mutant
50. The ins and outs of protein translocation
51. C2-domains, structure and function of a universal Ca2+-binding domain
52. Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae
53. Membrane dynamics in endocytosis
54. Ubiquitination of the yeast a-factor receptor
55. A large PEST-like sequence directs the ubiquitination, endocytosis, and vacuolar degradation of the yeast a-factor receptor
56. Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade
57. Clathrin-coated vesicle formation and protein sorting: An integrated process
58. Uracil-induced down-regulation of the yeast uracil permease
59. Monoubiquitin carries a novel internalization signal that is appended to activated receptors
60. Clathrin, adaptors and eps15 in endosomes containing activated epidermal growth factor receptors
61. Nitrogen-regulated ubiquitination of the gap1 permease of Saccharomyces cerevisiae
62. The yeast Npi1/Rsp5 ubiquitin ligase lacking its N-terminal C2 domain is competent for ubiquitination but not for subsequent endocytosis of the gap1 permease
63. NH4+-induced down-regulation of the Saccharomyces cerevisiae Gap1p permease involves its ubiquitination with lysine-63-linked chains
64. A role for unsaturated fatty acids in mitochondrial movement and inheritance
65. EH domain proteins Pan1p and End3p are components of a complex that plays a dual role in organization of the cortical actin cytoskeleton and endocytosis in Saccharomyces cerevisiae
66. Pan1p, End3p, and Sla1p, three yeast proteins required for normal cortical actin cytoskeleton organization, associate with each other and play essential roles in cell wall morphogenesis
67. A function for monoubiquitination in the internalization of a G protein-coupled receptor
68. kip1 is instigated by Jab 1
69. Eps15 is recruited to the plasma membrane upon epidermal growth factor receptor activation and localizes to components of the endocytic pathway during receptor internalization
70. Epidermal growth factor induces ubiquitination of Eps15
71. In vivo phosphorylation of the yeast uracil permease
72. Functional domains of the Rsp5 ubiquitin-protein ligase
73. The RING finger of c-Cb1 mediates desensitization of the epidermal growth factor receptor
74. Protein traffic in the yeast endocytic and vacuolar protein sorting pathways
75. Yeast epsins contain an essential N-terminal ENTH domain, bind clathrin and are required for endocytosis
76. End4p/Sla2p interacts with actin-associated proteins for endocytosis in Saccharomyces cerevisiae
77. Physical association of ubiquitin ligases and the 26S proteasome
78. MDP1, a Saccharomyces cerevisiae gene involved in mitochondrial/cytoplasmic protein distribution, is identical to the ubiquitin-protein ligase gene RSP5