Agonist efficacy and receptor efficiency in heterozygous CB1 knockout mice: Relationship of reduced CB1 receptor density to G-protein activation

Journal of Neurochemistry

Volumn 77, Issue 4, 2001, Pages 1048-1057

  Selley, Dana E ^a   Rorrer, W Kirk ^a   Breivogel, Christopher S ^a   Zimmer, Anne M ^b   Zimmer, Andreas ^b   Martin, Billy R ^a   Sim Selley, Laura J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF BONN   (Germany)

Author keywords

9 THC; 212 2; Cannabinoid; CB1 knockout; Efficacy; G protein; WIN 55

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID; CANNABINOID 1 RECEPTOR; DRONABINOL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); METHANANDAMIDE; SULFUR 35;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN REGION; CEREBELLUM; CINGULATE GYRUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; GENE ACTIVATION; GLOBUS PALLIDUS; HETEROZYGOTE; HIPPOCAMPUS; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECEPTOR DENSITY; SCATCHARD PLOT;

ANIMALS; ARACHIDONIC ACIDS; BINDING SITES; BRAIN; CANNABINOIDS; CELL MEMBRANE; CEREBELLUM; CORPUS STRIATUM; CROSSES, GENETIC; FEMALE; GLOBUS PALLIDUS; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GYRUS CINGULI; HETEROZYGOTE; HIPPOCAMPUS; KINETICS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MORPHOLINES; NAPHTHALENES; ORGAN SPECIFICITY; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; TETRAHYDROCANNABINOL;

ANIMALIA;

EID: 0035023150     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00308.x     Document Type: Article

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