The CB1 cannabinoid receptor juxtamembrane C-terminal peptide confers activation to specific G proteins in brain

Molecular Pharmacology

Volumn 57, Issue 1, 2000, Pages 162-170

  Mukhopadhyay, Somnath ^a   McIntosh, Helen H ^a   Houston, Devin B ^b   Howlett, Allyn C ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b National Enzyme Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; GUANINE NUCLEOTIDE BINDING PROTEIN; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; CARBOXY TERMINAL SEQUENCE; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RAT; SIGNAL TRANSDUCTION;

BINDING, COMPETITIVE; BRAIN; CANNABINOIDS; CHOLIC ACIDS; GTP-BINDING PROTEIN ALPHA SUBUNIT, GI2; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEINS; GUANOSINE TRIPHOSPHATE; HETEROTRIMERIC GTP-BINDING PROTEINS; MEMBRANE PROTEINS; PEPTIDE FRAGMENTS; POLYMERS; PRECIPITIN TESTS; PROTO-ONCOGENE PROTEINS; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SIGNAL TRANSDUCTION;

EID: 0033981921     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Blumer KJ, Reneke JE and Thorner J (1988) The STE2 gene product is the ligand-binding component of the α-factor receptor of Saccharomyces cerevisiae. J Biol Chem 263:10836-10842.
2. Bouaboula M, Perrachon S, Milligan L, Canat X, Rinaldi-Carmona M, Portier M, Barth F, Calandras B, Pecceu F, Lupker J, Maffrand J-P, Le Fur G and Casellas P (1997) A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. J Biol Chem 272:22330-22339.
3. 2 peripheral cannabinoid receptor: Involvement of both mitogen-activated protein kinase and induction of krox-24. Eur J Biochem 237: 704-711.
4. Breivogel CS, Sim LJ and Childers SR (1997) Regional differences in cannabinoid receptor/G protein coupling in rat brain. J Pharmacol Exp Ther 282:1632-1642.
5. 1 adenosine receptors in brain cortex. J Neurosci Res 42: 818-828.
6. Cvejic S and Devi LA (1997) Dimerization of the δ opioid receptor: Implication for a role in receptor internalization. J Biol Chem 272:26959-26964.
7. 12 with interleukin-8 receptors. J Biol Chem 271:12783-12789.
8. 2 receptors. Mol Pharmacol 48:443-450.
9. Frances B, Puget A, Moisand C and Meunier J-C (1990) Apparent precoupling of κ-but not μ-opioid receptors with a G protein in the absence of agonist. Eur J Pharmacol 189:1-9.
10. Galiegue S, Sophie M, Marchand J, Dussossoy D, Carriere D, Carayon P, Bouaboula M, Shire D, LeFur G and Casellas P (1995) Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 232:54-61.
11. Gu Y-Z. and Schonbrunn A (1997) Coupling specificity between somatostatin receptor sst2A and G proteins: Isolation of the receptor-G protein complex with a receptor antibody. Mol Endocrinol 11:527-537.
12. 2-adrenergic receptor transmembrane domain inhibits both receptor dimerization and activation. J Biol Chem 271:16384-16392.
13. Herberg JT, Codina J, Rich K, Rojas FJ and Iyengar R (1984) The hepatic glucagon receptor: Solubilization, characterization, and development of an affinity adsorption assay for the soluble receptor. J Biol Chem 259:9285-9294.
14. Herkenham M, Lynn AB, Johnson MR, Melvin LS, deCosta BR and Rice KC (1991) Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study. J Neurosci 11: 563-583.
15. Higashijima T, Burnier J and Ross EM (1990) Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines: Mechanism and structural determinants of activity. J Biol Chem 265:14176-14186.
16. Houston DB and Howlett AC (1993) Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins. Mol Pharmacol 43:17-22.
17. Houston DB and Howlett AC (1998) Differential receptor-G protein coupling evoked by dissimilar cannabinoid receptor agonists. Cell Signal 10:667-874.
18. Howlett AC (1995) Pharmacology of cannabinoid receptors. Annu Rev Pharmacol Toxicol 35:607-634.
19. 1 receptor ligands. Life Sci 65:617-625.
20. 1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Mol Pharmacol 53:504-510.
21. Konig B, Arendt A, McDowell J, Kahlert M, Hargrave P and Hofmann K (1989) Three cytoplasmic loops of rhodopsin interact with transducin. Proc Natl Acad Sci USA 86:6878-6882.
22. b receptor function. Science (Wash DC) 283:74-77.
23. Matesic DF, Manning DR and Luthin GR (1991) Tissue-dependent association of muscarinic acetylcholine receptors with guanine nucleotide-binding regulatory proteins. Mol Pharmacol 40:347-353.
24. Matesic DF, Manning DR, Wolfe BB and Luthin GR (1989) Pharmacological and biochemical characterization of complexes of muscarinic acetylcholine receptor and guanine nucleotide-binding protein. J Biol Chem 264:21638-21645.
25. Matsuda LA, Bonner TI and Lolait SJ (1993) Localization of cannabinoid receptor mRNA in rat brain. J Comp Neurol 327:535-550.
26. Merkouris M, Dragatsis I, Megaritis G, Konidakis G, Zioudrou C, Milligan G and Georgoussi Z (1996) Identification of the critical domains of the δ-opioid receptor involved in G protein coupling using site-specific synthetic peptides. Mol Pharmacol 50:985-993.
27. 1 cannabinoid receptor C-terminal juxtamembrane region: Structural requirements determined by peptide analysis. Biochemistry 38:3447-3455.
28. Munch G, Dees C, Hekman M and Palm D (1991) Multisite contacts involved in coupling of the β-adrenergic receptor with the stimulatory guanine-nucleotide-binding regulatory protein: Structural and functional studies by β-receptor-site-specific synthetic peptides. Eur J Biochem 198:357-364.
29. Murray-Whelan R and Schlegel W (1992) Brain somatostatin receptor-G protein interaction Gα C-terminal antibodies demonstrate coupling of the soluble receptor with Gi(1-3) but not with Go. J Biol Chem 267:2960-2965.
30. Namba T, Sugimoto Y, Negishi M, Irie A, Ushikubi F, Kakizuka A, Ito S, Ichikawa A and Narumiya S (1993) Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G protein specificity. Nature (Lond) 365:166-170.
31. L dopamine receptor in Sf9 cells. J Neurochem 63:1589-1595.
32. Ng GYK, O'Dowd BF, Lee SP, Chung HT, Brann MR, Seeman P and George SR (1996) Dopamine D2 receptor dimers and receptor-blocking peptides. Biochem Biophys Res Commun 227:200-204.
33. Okuma Y and Reisine T (1992) Immunoprecipitation of alpha 2a-adrenergic receptor-GTP-binding protein complexes using GTP-binding protein selective antisera: Changes in receptor/GTP-binding protein interaction following agonist binding. J Biol Chem 267:14826-14831.
34. Pronin AN and Gautam N (1994) Characterization of antibodies for various G protein βand γ subunits. Methods Enzymol 237:482-498.
35. Sano T, Ohyama K, Yamono Y and Nakagomi Y (1997) A domain for G protein coupling in the carboxyl terminal tail of rat angiotensin II receptor type IA. J Biol Chem 272:23631-23636.
36. Schreiber R, Prossnitz E, Ye R, Cochrane C and Bokoch G (1994) Domains of the human neutrophil N-formyl peptide receptor involved in G protein coupling: Mapping with receptor-derived peptides. J Biol Chem 269:326-331.
37. Schreurs J, Yamamoto R, Lyons J, Munemitsu S, Conroy L, Clark R, Takeda Y, Krause JE and Innis M (1995) Functional wild-type and carboxy-terminal-tagged rat substance P receptors expressed in baculovirus-infected insect Sf9 cells. J Neurochem 64:622-1631.
38. 2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein. J Biol Chem 262:4860-4867.
39. Shirai H, Takahashi K, Katada T and Inagami T (1995) Mapping of G protein coupling sites of the angiotensin II type 1 receptor. Hypertension 25:726-730.
40. Wess J (1998) Molecular basis of receptor/G protein-coupling selectivity. Pharmacol Ther 80:231-264.
41. z AM and Brass LF (1990) Identification of the pertussis toxin-sensitive G proteins in platelets, megakaryocytes, and human erythroleukemia cells. Blood 76:721-730.
42. Wreggett KA and Wells JW (1995) Cooperativity manifest in the binding properties of purified cardiac muscarinic receptors. J Biol Chem 270:22499-22499.