Agonist and inverse agonist efficacy at human recombinant serotonin 5-HT(1A) receptors as a function of Receptor:G-protein stoichiometry

Neuropharmacology

Volumn 36, Issue 4-5, 1997, Pages 451-459

  Newman Tancredi, A ^a   Conte, C ^a   Chaput, C ^a   Verriele L ^a   Millan, M J ^a  

^a INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

5 HT(1A) receptor; 35S GTP S binding; G protein; Inverse agonism; S 15535; Stoichiometry

Indexed keywords

1 (1,4 BENZODIOXAN 5 YL) 4 (2 INDANYL)PIPERAZINE; ELTOPRAZINE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PARTIAL AGONIST; RADIOLIGAND; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SPIPERONE; UNCLASSIFIED DRUG;

AGONIST; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; RECOMBINANT DNA TECHNOLOGY; STOICHIOMETRY;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CHO CELLS; CRICETINAE; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); PIPERAZINES; RADIOISOTOPE DILUTION TECHNIQUE; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS;

EID: 0030915526     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(97)00022-1     Document Type: Article

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