Regional differences in cannabinoid receptor/G-protein coupling in rat brain

Journal of Pharmacology and Experimental Therapeutics

Volumn 282, Issue 3, 1997, Pages 1632-1642

  Breivogel, Christopher S ^a   Sim, Laura J ^a   Childers, Steven R ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); RIMONABANT;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

ANIMALS; AUTORADIOGRAPHY; BRAIN; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); MALE; MORPHOLINES; NAPHTHALENES; PIPERIDINES; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0030988864     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. i1 in rat central nervous tissues. J. Biochem. 108: 988.-994, 1990.
2. BIDAUT-RUSSELL, M., DEVANE, W. A. AND HOWLETT, A. C.: Cannabinoid receptors and modulation of cyclic AMP accumulation in the rat brain. J. Neurochem. 55: 21-26, 1990.
3. BRADFORD, M. M.: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
4. BREIVOGEL, C. S., SELLEY, D. E. AND CHILDERS, S. R.: Acute and chronic effects of opioids on delta and mu receptor activation of G-proteins in NG108-15 and SK-N-SH cell membranes. J. Neurochem. 68: 1462-1472, 1997.
5. 50) of an enzymatic reaction. Biochem. Pharmacol. 22: 3099-4002, 1973.
6. CHILDERS, S. R. AND DEADWYLER, S. A.: Role of cyclic AMP in the actions of cannabinoid receptors. Biochem. Pharmacol. 52: 819-827, 1996.
7. DEADWYLER, S. A., HAMPSON, R. E. AND CHILDERS, S. R.: Functional significance of cannabinoid receptors in brain. In Cannabinoid Receptors, ed. by R. Pertwee, pp. 205-231, Academic Press, San Diego, CA, 1995.
8. DEVANE, W. A., DYSARZ, F. A. I., JOHNSON, M. R., MELVIN, L. S. AND HOWLETT, A. C.: Determination and characterization of a cannabinoid receptor in rat brain. Mol. Pharmacol. 34: 605-613, 1988.
9. DEWEY, W. L.: Cannabinoid pharmacology. Pharmacol. Rev. 38: 151-178, 1986.
10. GADDUM, J. H.: Theories of drug antagonism. Pharmacol. Rev. 9: 211-218, 1957.
11. GIERSCHIK, P., MOGHTADER, R., STRAUB, C., DIETERICH, K. AND JAKOBS, K. H.: Signal amplification in HL-60 granulocytes: Evidence that the chemotactic peptide receptor catalytically activates guanine-nucleotide-binding regulatory proteins in native plasma membranes. Eur. J. Biochem. 197: 725-732, 1991.
12. HAMPSON, R. E., EVANS, G. J. O., MU, J., ZHUANG, S., KING, V. C., CHILDERS, S. R. AND DEADWYLER, S. A.: Role of cyclic AMP dependent protein kinase in cannabinoid receptor modulation of potassium "A-current" in cultured rat hippocampal neurons. Life Sci. 56: 2081-2088, 1995.
13. HERKENHAM, M., LYNN, A. B., DE COSTA, B. R. AND RICHFIELD, E. K.: Neuronal localization of cannabinoid receptors in the basal ganglia of the rat. Brain Res. 547: 267-274, 1991a.
14. HERKENHAM, M., LYNN, A. B., JOHNSON, M. R., MELVIN, L. S., DE COSTA, B. R. AND RICE, K. C.: Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci. 11: 563-583, 1991b.
15. HILF, G., GIERSCHIK, P. AND JAKOBS, K. H.: Muscarinic acetylcholine receptor-stimulated binding of guanosine 5′-O-(3-thiotriphosphate) to guanine-nucleotide-binding proteins in cardiac membranes. Eur. J. Biochem. 186: 725-731, 1989.
16. HOLLISTER, L. E.: Health aspects of cannabis. Pharmacol. Rev. 38: 1-20, 1986.
17. HOWLETT, A. C.: Inhibition of neuroblastoma adenylyl cyclase by cannabinoid and nantradol compounds. Life Sci. 35: 1803-1810, 1984.
18. HOWLETT, A. C.: Cannabinoid inhibition of adenylate cyclase: Biochemistry of the response in neuroblastoma cell membranes. Mol. Pharmacol. 27: 429-436, 1985.
19. HOWLETT, A. C. AND FLEMING, R. M.: Cannabinoid inhibition of adenylate cyclase: Pharmacology of the response in neuroblastoma cell membranes. Mol. Pharmacol. 26: 532-538, 1984.
20. i in the inhibition of adenylate cyclase by cannabimimetic drugs. Mol. Pharmacol. 29: 307-313, 1986.
21. o protein. J. Biol. Chem. 265: 11220-11226, 1990.
22. JANSEN, E. M., HAYCOCK, D. A., WARD, S. J. AND SEYBOLD, V. S.: Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. Brain Res. 575: 93-102, 1992.
23. JONES, D. T. AND REED, R. R.: Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. J. Biol. Chem. 262: 14241-14249, 1987.
24. KENAKIN, T.: Efficacy. In Pharmacologic Analysis of Drug-Receptor Interaction, ed. by T. Kenakin, pp. 249-277, Raven, New York, 1993.
25. KENAKIN, T. P. AND MORGAN, P. H.: Theoretical effects of single and multiple transducer receptor coupling proteins on estimates of the relative potency of agonists. Mol. Pharmacol. 35: 214-222, 1989.
26. KLEUSS, C., SCHERUEBL, H., HESCHELER, J., SCHULTZ, G. AND WITTIG, B.: Different β-subunits determine G-protein interaction with transmembrane receptors. Nature 358: 424-426, 1992.
27. 35S]thio)triphosphate binding. Mol. Pharmacol. 44: 115-123, 1993.
28. MACKIE, K. AND HILLE, B.: Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc. Natl. Acad. Sci. U.S.A. 89: 3825-3829, 1992.
29. MACKIE, K., LAI, Y., WESTENTBROEK, R. AND MITCHELL, R.: Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in AtT20 cells transfected with rat brain cannabinoid receptor. J. Neurosci. 15: 6552-6561, 1995.
30. MARTIN, B. R.: Cellular effects of cannabinoids. Pharmacol. Rev. 38: 45-74, 1986.
31. MATSUDA, L. A., LOLAIT, S. J., BROWNSTEIN, M. J., YOUNG, A. L. AND BONNER, T. I.: Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346: 561-564, 1990.
32. i2. Biochem. J. 267: 391-398, 1990.
33. MUNSON, P. J. AND RODBARD, D.: LIGAND: A versatile approach for characterization of ligand-binding systems. Anal. Biochem. 107: 220-239, 1980.
34. i2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells. J. Biol. Chem. 266: 3365-3368, 1991.
35. PFEUFFER, T. AND HELMREICH, E. J. M.: Activation of pigeon erythrocyte membrane adenylate cyclase by guanyl nucleotide analogues and separation of a nucleotide binding protein. J. Biol. Chem. 250: 867-876, 1975.
36. s-stimulated adenylate cyclase in brain membranes by low pH pretreatment: correlation with altered guanine nucleotide exchange. J. Neurochem. 53: 219-225, 1989.
37. RINALDI-CARMONA, M., BARTH, F., HEAULME, M., SHIRE, D., CALANDRA, B., CONGY, C., MARTINEZ, S., MARUANI, J., NELIAT, G., CAPUT, D., FERRARA, P., SOUBRIE, P., BRELIERE, J. C. AND LE FUR, G.: SR141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350: 240-244, 1994.
38. 3H]-SR 141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain. Life Sci. 58: 1239-1247, 1996.
39. 35S]GTPγS binding in rat thalamus and cultured cell lines: Signal transduction mechanisms underlying agonist efficacy. Mol. Pharmacol. 51: 87-96, 1997.
40. 35S]thio)triphosphate binding in rat brain membranes. Life Sci. 59: 659-668, 1996.
41. SENOGLES, S. E., SPIEGEL, A. M., PADRELL, E., IYENGAR, R. AND CARON, M. C.: Specificity of receptor-G protein interactions. J. Biol. Chem. 265: 4507-4514, 1990.
42. SHIRE, D., CARILLON, C., KAGHAD, M., CALANDRA, B., RINALDI-CARMONA, M., LE FUR, G., CAPUT, D. AND FERRARA, P.: An Amino-terminal variant of the central cannabinoid receptor resulting from alternative splicing. J. Biol. Chem. 270: 3726-3731, 1995.
43. 35S]GTPγS autoradiography in rat brain. J. Neurosci. 16: 8057-8066, 1996a.
44. 35S]thio]-triphosphate binding. Proc. Natl. Acad. Sci. U.S.A. 92: 7242-7246, 1995.
45. 35S]GTPgS autoradiography in rat brain. J. Neurosci. 16: 2684-2692, 1996b.
46. SIM, L. J., SELLEY, D. E., XIAO, R. AND CHILDERS, S. R.: Differences in G-protein activation by mu and delta opioid, and cannabinoid, receptors in rat striatum. Eur. J. Pharmacol. 307: 95-107, 1996c.
47. 35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells. Mol. Pharmacol. 47: 848-854, 1995.