Δ9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in mouse brain

European Journal of Pharmacology

Volumn 323, Issue 2-3, 1997, Pages

  Burkey, Thomas H ^a   Quock, Raymond M ^a,b   Consroe, Paul ^a   Roeske, William R ^a   Yamamura, Henry I ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

Brain, mouse; G protein; 9 Tetrahydrocannabinol

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID RECEPTOR; DRONABINOL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PARTIAL AGONIST;

ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; CONTROLLED STUDY; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030901709     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00146-5     Document Type: Article

References (8)

1. Dewey, W.L., 1986. Cannabinoid pharmacology. Pharmacol. Rev. 38, 151-178.
2. Hewlett, A.C., 1995. Cannabinoid compounds and signal transduction mechanisms. In: Pertwee, R. (Ed.), Cannabinoid Receptors. Academic Press, London, pp. 167-204.
3. Lichtman, A.H., Cook, S.A., Martin, B.R., 1996. Investigation of brain sites mediating cannabinoid-induced antinociception in rats: evidence supporting periaqueductal gray involvement. J. Pharmacol. Exp. Ther. 276, 585-593.
4. Matsuda, L.A., Lolait, S.J., Brownstein, M.J., Young, A.C., Bonner, T.I., 1990. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 346, 561-564.
5. Razdan, R.K., 1986. Structure-activity relationships in cannabinoids. Pharmacol. Rev. 38, 75-149.
6. 3H]-SR 141716A, a selective brain (CB1) cannabinoid receptor antagonist, in rodent brain. Life Sci. 58, 1239-1247.
7. 35S]thio)triphosphate binding in rat brain membranes. Life Sci. 59, 659-668.
8. 35S]GTP-γS autoradiography in rat brain. J. Neurosci. 16, 8057-8066.