The immune response to ocular herpes simplex virus type 1 infection

Experimental Biology and Medicine

Volumn 226, Issue 5, 2001, Pages 353-366

  Carr, Daniel J J ^a   Härle, Peter ^a   Gebhardt, Bryan M ^b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokines; Herpes simplex virus type 1; Neuroimmunology; Viral latency

Indexed keywords

ACICLOVIR; ANTIVIRUS AGENT; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PLASMID DNA;

ANIMAL MODEL; CONTROLLED STUDY; GENE THERAPY; HERPES SIMPLEX KERATITIS; HERPES SIMPLEX VIRUS 1; KERATITIS; LATENT PERIOD; MOUSE; NONHUMAN; SHORT SURVEY; VIRUS INFECTION; VIRUS REPLICATION;

EID: 0034988468     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1177/153537020122600501     Document Type: Short Survey

References (149)

1. Cell-mediated immunity to herpes simplex virus in man
2. Cell-mediated immune responses in recurrent herpesvirus infections. I. Lymphocyte proliferation assay
3. Role of T lymphocytes in cellular immune responses during herpes simplex virus infection in humans
4. Immunological aspects of ocular herpes simplex disease
5. Herpes keratitis and the immune system
6. Herpes simplex virus immunology: Problems, progress, and promises
7. Herpes simplex keratitis: Role of viral infection versus immune response
8. Herpes simplex virus infection: Biology, treatment, and prevention
9. The role of immune mechanisms in control of herpes simplex virus infection of the peripheral nervous system
10. Herpes simplex: Evolving concepts
11. Herpes simplex virus
12. Molecular aspects of herpes simplex virus I latency, reactivation, and recurrence
13. Herpes simplex virus latency and the immune response
14. Abnormalities of the tears and treatment of dry eyes
15. Human leukocyte interferon for the prevention of recurrences of herpetic keratitis
16. Recombinant HulFN-gamma prevents herpes simplex keratitis in African green monkeys: Demonstration of synergism with recombinant HulFN-alpha 2
17. Endogenously produced interferon-α protects mice from herpes simplex virus type 1 corneal disease
18. Synergistic anti-herpes effect of TNF-α and IFN-γ in human corneal epithelial cells compared with that in corneal fibroblasts
19. T cell cytokine mRNA expression during the course of the immunopathologic ocular disease herpetic stromal keratitis
20. Interferon-γ regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas
21. Structure and function of the cornea
22. Requirement for cellular cyclin-dependent kinases in herpes simplex virus replication and transcription
23. L13 viral genes
24. Roscovitine, a specific inhibitor of cellular cyclin-dependent kinases, inhibits herpes simplex virus DNA synthesis in the presence of viral early proteins
25. Herpes simplex viral infections
26. Immunopathogenesis of corneal inflammation in herpes simplex virus stromal keratitis: Role of the polymorphonuclear leukocyte
27. Ocular infection with herpes simplex virus in nonimmune and immune mice
28. Contribution of virus and immune factors to herpes simplex virus type 1-induced corneal pathology
29. Phenotypic and functional studies on ocular T cells during herpetic infections of the eye
30. Activation of NK cells in mice following corneal infection with herpes simplex virus type-I
31. Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea
32. Role of MIP-2 in neutrophil migration and tissue injury in the herpes simple virus-1-infected cornea
33. The role of natural killer cells in protection of mice against death and corneal scarring following ocular HSV-1 infection
34. Virus-induced immunoinflammatory lesions in the absence of viral antigen recognition
35. Herpes simplex virus replication-induced expression of chemokines and proinflammatory cytokines in the eye: Implications in herpetic stromal keratitis
36. Immune cell infiltration in corneas of mice with recurrent herpes simplex virus disease
37. Quantitative studies on Langerhans cells in mouse corneal epithelium following infection with herpes simplex virus
38. The relationship of corneal Langerhans cells to herpes simplex antigens during dendritic keratitis
39. Critical role of corneal Langerhans cells in the CD4- but not CD8-mediated immunopathology in herpes simplex virus-1-infected mouse corneas
40. Presence of Langerhans cells in the central cornea linked to the development of ocular herpes in mice
41. Corneal Langerhans cell dynamics after herpes simplex virus reactivation
42. + T cells in corneas of herpetic stromal keratitis patients
43. Tegument-specific virus-reactive CD4 T cells localize to the cornea in herpes simplex virus interstitial keratitis in humans
44. The relationship between virus chemotherapy, secretory antibody formation and recurrent herpetic disease
45. Studies on HSV-specific IgA antibodies in lacrimal fluid from patients with herpes keratitis by solid phase radioimmunoassay
46. Tear and serum antibody levels in ocular herpetic infection: Diagnostic precision of secretory IgA
47. Herpetic stromal keratitis: Evidence for cell-mediated immunopathogenesis
48. Herpetic keratitis in athymic (nude) mice
49. Spread of virus and distribution of latent infection following ocular herpes simplex in the non-immune and immune mouse
50. Protective immunity against herpetic ocular disease in an outbred mouse model
51. Ocular avirulence of a herpes simplex virus type 1 strain is associated with heightened sensitivity to alpha/ beta interferon
52. IFN-γ and IL-2 are protective in the skin but pathologic in the corneas of HSV-1-infected mice
53. Proinflammatory functions of IL-2 in herpes simplex virus corneal infection
54. Specificity of human natural killer cells in limiting dilution culture for determinants of herpes simplex virus type 1 glycoproteins
55. Activation of human natural killer cells by herpes simplex virus type 1-infected cells
56. Severe herpesvirus infections in an adolescent without natural killer cells
57. Macrophage extrinsic antiviral activity during herpes simplex virus infection
58. Analysis of the inhibitory effect of peritoneal macrophages on the spread of herpes simplex virus
59. Activated macrophages mediate interferon-independent inhibition of herpes simplex virus
60. Use of interleukin-2 and macrophages to treat herpes simplex virus infection in neonatal mice
61. Interleukin-2 protects neonatal mice from lethal herpes simplex virus infection: A macrophage-mediated, γ-interferon-induced mechanism
62. Cell-mediated immunity in herpes corneal stromal disease
63. Herpes simplex virus-induced stromal keratitis: Role of T-lymphocyte subsets in immunopathology
64. + T-lymphocyte depletion on the induction and expression of herpes simplex stromal keratitis
65. + cytotoxic T lymphocytes specific for herpes simplex virus-1: Implications for the development of herpetic stromal keratitis in mice
66. Predominance of Th1 cells in ocular tissues during herpetic stromal keratitis
67. Exacerbation of murine herpes simplex virus-mediated stromal keratitis by Th2 type T cells
68. Herpetic stromal keratitis in the reconstituted scid mouse model
69. CD4+ Vβ8+ T cells mediate herpes stromal keratitis
70. Pathogenesis of herpetic encephalitis in mice after ophthalmic inoculation
71. Viral, neuronal and immune factors which may influence herpes simplex virus (HSV) latency and reactivation
72. Experimental investigation of herpes simplex virus latency
73. Infection and spread of alphaherpesviruses in the nervous system
74. Maintenance of latent herpetic infection: An apparent role for anti-viral IgG
75. Restricted replication of herpes simplex virus in spinal ganglia of resistant mice is accompanied by an early infiltration of immunoglobulin G-bearing cells
76. Neuroinvasive properties of herpes simplex virus type 1 glycoprotein variants are controlled by the immune response
77. Herpes simplex virus type 1 mutant strain in1814 establishes a unique, slowly progressing infection in SCID mice
78. Restricted herpes simplex virus type 1 gene expression within sensory neurons in the absence of functional B and T lymphocytes
79. Establishment of latent herpes simplex virus type 1 infection in resistant, sensitive, and immnnodeficient mouse strains
80. Latency of herpes simplex virus in absence of neutralizing antibody: Model for reactivation
81. The herpes simplex virus type 1 strain 17+γ34.5 deletion mutant 1716 is avirulent in SCID mice
82. Anti-CD8 impairs clearance of herpes simplex virus from the nervous system: Implications for the fate of virally infected neurons
83. + T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons
84. Control of acute herpes simplex virus infection: T cell-mediated viral clearance is dependent upon interferon-γ (IFN-γ)
85. Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1
86. Persistent cytokine expression in trigeminal ganglion latently infected with herpes simplex virus type 1
87. Role for gamma interferon in control of herpes simplex virus type 1 reactivation
88. HLA class I molecules are not transported to the cell surface in cells infected with herpes simplex virus types I and 2
89. + T lymphocytes
90. Herpes simplex virus turns off the TAP to evade host immunity
91. Cell surface expression of MHC molecules in glioma cells infected with herpes simplex virus type-I
92. Herpes simplex virus type 1 renders infected cells resistant to cytotoxic T-lymphocyte-induced apoptosis
93. Herpes simplex virus inhibits apoptosis through the action of two genes, Us5 and Us3
94. Herpes simplex virus type 1 induces apoptosis in peripheral blood T lymphocytes
95. Herpes simplex virus type 1 infection of activated cytotoxic T cells: Induction of fratricide as a mechanism of viral immune evasion
96. Induction of transforming growth factor-β1 by herpes simplex virus
97. TGF-β suppresses IFN-γ induction of class II MHC gene expression by inhibiting class II transactivator messenger RNA expression
98. B cell-deficient mice have increased susceptibility to HSV-1 encephalomyelitis and mortality
99. Neutralizing antibodies inhibit axonal spread of herpes simplex virus type 1 to epidermal cells in vitro
100. Humoral response to herpes simplex virus is complement-dependent
101. The InterferonsL: Mechanisms of action and clinical applications
102. Interferons regulate the phenotype of wild-type and mutant herpes simplex viruses in vivo
103. Herpes simplex virus ICPO mutants are sensitive to interferon
104. Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latency
105. Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript
106. The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency
107. The probability of in vivo reactivation of herpes simplex virus type 1 increases with the number of latently infected neurons in the ganglia
108. Immune cell infiltration and persistence in the mouse trigeminal ganglion after infection of the cornea with herpes simplex virus type 1
109. Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection
110. The persistent elevated cytokine mRNA levels in trigeminal ganglia of mice latently infected with HSV-1 are not due to the presence of latency associated transcript (LAT) RNAs
111. Acyclovir blocks cytokine gene expression in trigeminal ganglia latently infected with herpes simplex virus type 1
112. Transgenic expression of interleukin-6 in the central nervous system confers protection against acute herpes simplex virus type-I infection
113. Lack of interleukin-6 (IL-6) enhances susceptibility to infection but does not alter latency or reactivation of herpes simplex virus type 1 in IL-6 knockout mice
114. Reactivation of herpes simplex virus type 1 in the mouse trigeminal ganglion: An in vivo study of virus antigen and cytokines
115. Upregulation of class I major histocompatibility complex gene expression in primary sensory neurons, satellite cells, and Schwann cells of mice in response to acute but not latent herpes simplex virus infection in vivo
116. Cell surface expression of H2 antigens on primary sensory neurons inn response to acute but not latent herpes simplex virus infection in vivo
117. Small amounts of exogenous IL-4 increase the severity of encephalitis induced in mice by the intranasal infection of herpes simplex virus type 1
118. The role of interleukin (IL)-2 and IL-4 in herpes simplex virus type 1 ocular replication and eye disease
119. Cytokine and chemokine production in HSV-1 latently infected trigeminal ganglion cell cultures: Effects of hyperthermic stress
120. Lymphocytes delay kinetics of HSV-1 reactivation from in vitro explants of latent infected trigeminal ganglia
121. Herpes labialis associated with recombinant human ciliary neurotrophic factor
122. Anti-interleukin-6 antibodies inhibit herpes simplex virus reactivation
123. Neuronal reactivation of herpes simplex virus involves interleukin-6
124. Role of the hypothalamic pituitary adrenal axis and IL-6 in stress-induced reactivation of latent herpes simplex virus type 1
125. The relationship between interleukin-6 and herpes simplex virus type 1: Implications for behavior and immunopathology
126. Role of viral infection in the aetiology of multiple sclerosis: Status of current knowledge and therapeutic implications
127. Evidence for antigenic cross-reactivity between herpes virus and the acetylcholine receptor
128. Status of gene therapy in 1997: Molecular mechanisms, disease targets, and clinical applications
129. Cytokine gene therapy: Hopes and pitfalls
130. Less hype, more biology needed for gene therapy
131. Transfer and expression of foreign genes in mammalian cells
132. Induction of interferon synthesis and activation of interferon stimulated genes by liposomal transfection reagents
133. Distribution fate and mechanism of immune modulation following mucosal delivery of plasmid DNA encoding IL-10
134. Involvement of specific mechanism in plasmid DNA uptake by mouse peritoneal macrophages
135. Uptake and gene expression of naked plasmid DNA in cultured brain microvessel endothelial cells
136. Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice
137. In vivo expression of an interferon-alpha gene by intramuscular injection of naked DNA
138. Antiviral activities of individual murine IFN-alpha subtypes in vivo: Intramuscular injection of IFN expression constructs reduces cytomegalovirus replication
139. Acyclovir for the prevention of recurrent herpes simplex virus eye disease
140. Resistance to antiviral drugs in herpes simplex virus infections among allogenetic stem cell transplant recipients: Risk factors and prognostic significance
141. Acyclovir resistance in herpes simplex virus isolates from keratitis cases: An analysis from a developing country
142. Suppression of ongoing ocular inflammatory disease by topical administration of plasmid DNA encoding IL-10
143. T cell cytokine mRNA expression during the course of the immunopathologic ocular disease herpetic stromal keratitis
144. Astrocyte-targeted expression of IFN-alphal protects mice from acute ocular herpes simplex virus type 1 infection
145. Ectopic expression of DNA encoding IFN-alpha 1 in the cornea protects mice from herpes simplex virus type 1-induced encephalitis
146. Plasmid DNA encoding IFN-alpha 1 antagonizes herpes simplex virus type 1 ocular infection through CD4+ and CD8+ T lymphocytes
147. A plasmid construct encoding murine interferon beta antagonizes the replication of herpes simplex virus type 1 in vitro and in vivo