메뉴 건너뛰기




Volumn 238, Issue 1, 1997, Pages 53-63

Acyclovir blocks cytokine gene expression in trigeminal ganglia latently infected with herpes simplex virus type 1

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; CYTOKINE;

EID: 0031564064     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1006/viro.1997.8806     Document Type: Article
Times cited : (49)

References (48)
  • 1
    • 0027998806 scopus 로고
    • Neuronal progenitors identified by their inability to express class I histocompatability antigens in response to interferon-γ
    • Bailey, K.A., Drago, J., and Bartlett, P. F. (1994). Neuronal progenitors identified by their inability to express class I histocompatability antigens in response to interferon-γ. J. Neurosci. Res. 39, 166-177.
    • (1994) J. Neurosci. Res. , vol.39 , pp. 166-177
    • Bailey, K.A.1    Drago, J.2    Bartlett, P.F.3
  • 2
    • 0021920763 scopus 로고
    • Adverse effects of high-dose intravenous acyclovir in ambulatory patients with acute herpes zoster
    • Bean, B., and Aeppli, D. (1985). Adverse effects of high-dose intravenous acyclovir in ambulatory patients with acute herpes zoster. J. Infect. Dis. 151, 362-365.
    • (1985) J. Infect. Dis. , vol.151 , pp. 362-365
    • Bean, B.1    Aeppli, D.2
  • 3
    • 0027364458 scopus 로고
    • Rapidly progressive acute renal failure due to acyclovir: Case report and review of the literature
    • Becker, B. N., Fall, P., Hall, C., Milam, D., Leonard, J., Glick, A., and Schulman, G. (1993). Rapidly progressive acute renal failure due to acyclovir: case report and review of the literature. Am. J. Kidney Dis. 22, 611-615.
    • (1993) Am. J. Kidney Dis. , vol.22 , pp. 611-615
    • Becker, B.N.1    Fall, P.2    Hall, C.3    Milam, D.4    Leonard, J.5    Glick, A.6    Schulman, G.7
  • 4
    • 0024383069 scopus 로고
    • Herpes simplex virus infection and damage in the central nervous system: Immune response to myelin basic protein
    • Bishop, S. A., and Hill, T. J. (1989). Herpes simplex virus infection and damage in the central nervous system: Immune response to myelin basic protein. J. Neurol. Sci. 91, 109-118.
    • (1989) J. Neurol. Sci. , vol.91 , pp. 109-118
    • Bishop, S.A.1    Hill, T.J.2
  • 5
    • 0027372802 scopus 로고
    • Prophylactic acyclovir effectively reduces herpes simplex virus type 1 reactivation after exposure of latently infected mice to ultraviolet B
    • Blatt, A. N., Laycock, K. A., Brady, R. H., Traynor, P., Krogstad, D. J., and Pepose, J. S. (1993). Prophylactic acyclovir effectively reduces herpes simplex virus type 1 reactivation after exposure of latently infected mice to ultraviolet B. Invest. Ophthalmol. Vis. Sci. 34, 3459-3465.
    • (1993) Invest. Ophthalmol. Vis. Sci. , vol.34 , pp. 3459-3465
    • Blatt, A.N.1    Laycock, K.A.2    Brady, R.H.3    Traynor, P.4    Krogstad, D.J.5    Pepose, J.S.6
  • 6
    • 0027478206 scopus 로고
    • Immunohistological characterization of acute herpes simplex virus infection in lumbar dorsal root ganglia of the rat
    • Blondeau, J. M., Aoki, F. Y., and Nagy, J. I. (1993). Immunohistological characterization of acute herpes simplex virus infection in lumbar dorsal root ganglia of the rat. J. Med. Microbiol. 38, 265-269.
    • (1993) J. Med. Microbiol. , vol.38 , pp. 265-269
    • Blondeau, J.M.1    Aoki, F.Y.2    Nagy, J.I.3
  • 7
    • 0029037526 scopus 로고
    • Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1
    • Cantin, E. M., Hinton, D. R., Chen, J., and Openshaw, H. (1995). Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J. Virol. 69, 4898-4905.
    • (1995) J. Virol. , vol.69 , pp. 4898-4905
    • Cantin, E.M.1    Hinton, D.R.2    Chen, J.3    Openshaw, H.4
  • 8
    • 0029954252 scopus 로고    scopus 로고
    • Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells
    • De La Torre, J. C., Mallory, M., Brot, M., Gold, L., Koob, G., Oldstone, M. B. A., and Masliah, E. (1996). Viral persistence in neurons alters synaptic plasticity and cognitive functions without destruction of brain cells. Virology 220, 508-515.
    • (1996) Virology , vol.220 , pp. 508-515
    • De La Torre, J.C.1    Mallory, M.2    Brot, M.3    Gold, L.4    Koob, G.5    Oldstone, M.B.A.6    Masliah, E.7
  • 9
    • 0029563335 scopus 로고
    • Intermediate forms of glycoconjugates are present in the envelope of herpes simplex virions during their transport along the exocytic pathway
    • Di Lazarro, C., Campadelli-Fiume, G., and Torri, M. R. (1995). Intermediate forms of glycoconjugates are present in the envelope of herpes simplex virions during their transport along the exocytic pathway. Virology 214, 619-623.
    • (1995) Virology , vol.214 , pp. 619-623
    • Di Lazarro, C.1    Campadelli-Fiume, G.2    Torri, M.R.3
  • 10
    • 0028849767 scopus 로고
    • Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus
    • Dingwell, K. S., Doering, L. C., and Johnson, D. C. (1995). Glycoproteins E and I facilitate neuron-to-neuron spread of herpes simplex virus. J. Virol. 69, 7087-7098.
    • (1995) J. Virol. , vol.69 , pp. 7087-7098
    • Dingwell, K.S.1    Doering, L.C.2    Johnson, D.C.3
  • 11
    • 0027754719 scopus 로고
    • Acyclovir: Discovery, mechanism of action, and selectivity
    • Elion, G. B. (1993). Acyclovir: Discovery, mechanism of action, and selectivity. J. Med. Virol. 41(Suppl. 1), 2-6.
    • (1993) J. Med. Virol. , vol.41 , Issue.SUPPL. 1 , pp. 2-6
    • Elion, G.B.1
  • 14
    • 0019869752 scopus 로고
    • Detection of an immediate early herpes simplex virus type 1 polypeptide in trigeminal ganglia from latently infected animals
    • Green, M. T., Courtney, R. J., and Dunkel, E. C. (1981). Detection of an immediate early herpes simplex virus type 1 polypeptide in trigeminal ganglia from latently infected animals. Infect. Immun. 34, 987-992.
    • (1981) Infect. Immun. , vol.34 , pp. 987-992
    • Green, M.T.1    Courtney, R.J.2    Dunkel, E.C.3
  • 15
    • 0027403428 scopus 로고
    • Acyclovir-induced neurotoxicity: Concentration-side effect relationship in acyclovir overdose
    • Haefeli, W. E., Schoenenberger, R. A. Z., Weiss, P., and Ritz, R. F. (1993). Acyclovir-induced neurotoxicity: Concentration-side effect relationship in acyclovir overdose. Am. J. Med. 94, 212-215.
    • (1993) Am. J. Med. , vol.94 , pp. 212-215
    • Haefeli, W.E.1    Schoenenberger, R.A.Z.2    Weiss, P.3    Ritz, R.F.4
  • 16
    • 0028787507 scopus 로고
    • Subversion of intracellular signal transduction by herpes simplex virus type 1
    • Halford, W. P., and Carr, D. J. J. (1995). Subversion of intracellular signal transduction by herpes simplex virus type 1. Adv. Neuroimmunol. 5, 327-334.
    • (1995) Adv. Neuroimmunol. , vol.5 , pp. 327-334
    • Halford, W.P.1    Carr, D.J.J.2
  • 17
    • 0030587885 scopus 로고    scopus 로고
    • Persistent cytokine expression in the trigeminal ganglion latently infected with herpes simplex virus type 1
    • Halford, W. P., Gebhardt, B. M., and Carr, D. J. J. (1996a). Persistent cytokine expression in the trigeminal ganglion latently infected with herpes simplex virus type 1. J. Immunol. 157, 3542-3549.
    • (1996) J. Immunol. , vol.157 , pp. 3542-3549
    • Halford, W.P.1    Gebhardt, B.M.2    Carr, D.J.J.3
  • 18
    • 0029956255 scopus 로고    scopus 로고
    • Mechanisms of herpes simplex virus type 1 reactivation
    • Halford, W. P., Gebhardt, B. M., and Carr, D. J. J. (1996b). Mechanisms of herpes simplex virus type 1 reactivation. J. Virol. 70, 5051-5060.
    • (1996) J. Virol. , vol.70 , pp. 5051-5060
    • Halford, W.P.1    Gebhardt, B.M.2    Carr, D.J.J.3
  • 19
    • 0029930161 scopus 로고    scopus 로고
    • Quantitation of HSV-1 DNA and LAT in rabbits trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency
    • Hill, J. M., Gebhardt, B. M., Wen, R., Bouterie, A. M., Thompson, H. W., O'Callaghan, R. J., Halford, W. P., and Kaufman, H. E. (1996a). Quantitation of HSV-1 DNA and LAT in rabbits trigeminal ganglia demonstrates a stable reservoir of viral nucleic acids during latency. J. Virol. 70, 3137-3141.
    • (1996) J. Virol. , vol.70 , pp. 3137-3141
    • Hill, J.M.1    Gebhardt, B.M.2    Wen, R.3    Bouterie, A.M.4    Thompson, H.W.5    O'Callaghan, R.J.6    Halford, W.P.7    Kaufman, H.E.8
  • 21
    • 0021713038 scopus 로고
    • Immunocytochemical localization of herpes simplex virus antigen in the trigeminal ganglia of experimentally infected mice
    • Itoyama, Y., Sekizawa, T., Openshaw, H., Kogure, K., and Kuroiwa, Y. (1984). Immunocytochemical localization of herpes simplex virus antigen in the trigeminal ganglia of experimentally infected mice. J. Neurol. Sci. 66, 67-75.
    • (1984) J. Neurol. Sci. , vol.66 , pp. 67-75
    • Itoyama, Y.1    Sekizawa, T.2    Openshaw, H.3    Kogure, K.4    Kuroiwa, Y.5
  • 22
    • 0026055288 scopus 로고
    • Viral persistence in neurons explained by lack of major histocompatibility class I expression
    • Joly, E., Mucke, L., and Oldstone, M. B. A. (1991). Viral persistence in neurons explained by lack of major histocompatibility class I expression. Science 253, 1283-1285.
    • (1991) Science , vol.253 , pp. 1283-1285
    • Joly, E.1    Mucke, L.2    Oldstone, M.B.A.3
  • 25
    • 84906644307 scopus 로고
    • Acyclovir vs isoprinone (immunovir) for suppression of recurrent genital herpes simplex infection
    • Kinghorn, G. R., Wooley, P. D., Thin, R. N. T., De Maubeuge, J., Foidart, J. M., and Engst, R. (1992). Acyclovir vs isoprinone (immunovir) for suppression of recurrent genital herpes simplex infection. Genitourin. Med. 68, 312-316.
    • (1992) Genitourin. Med. , vol.68 , pp. 312-316
    • Kinghorn, G.R.1    Wooley, P.D.2    Thin, R.N.T.3    De Maubeuge, J.4    Foidart, J.M.5    Engst, R.6
  • 26
    • 0016202984 scopus 로고
    • Pathogenesis of herpetic encephalitis in mice after ophthalmic inoculation
    • Knotts, F. B., Cook, M. L., and Stevens, J.G. (1974). Pathogenesis of herpetic encephalitis in mice after ophthalmic inoculation. J. Infect. Dis. 130, 16-27.
    • (1974) J. Infect. Dis. , vol.130 , pp. 16-27
    • Knotts, F.B.1    Cook, M.L.2    Stevens, J.G.3
  • 27
    • 0027184328 scopus 로고
    • Evidence for a novel regulatory pathway for herpes simplex virus gene expression in the trigeminal ganglion neurons
    • Kosz-Knenchak, M., Jacobson, J., Coen, D. M., and Knipe, D. M. (1993). Evidence for a novel regulatory pathway for herpes simplex virus gene expression in the trigeminal ganglion neurons. J. Virol. 67, 5383-5393.
    • (1993) J. Virol. , vol.67 , pp. 5383-5393
    • Kosz-Knenchak, M.1    Jacobson, J.2    Coen, D.M.3    Knipe, D.M.4
  • 28
    • 0028833335 scopus 로고
    • Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus
    • Kramer, M., and Coen, D. M. (1995). Quantification of transcripts from the ICP4 and thymidine kinase genes in mouse ganglia latently infected with herpes simplex virus. J. Virol. 69, 1389-1399.
    • (1995) J. Virol. , vol.69 , pp. 1389-1399
    • Kramer, M.1    Coen, D.M.2
  • 29
    • 0029656044 scopus 로고    scopus 로고
    • Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection
    • Liu, T., Tang, Q., and Hendricks, R. L. (1996). Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. J. Virol. 70, 264-271.
    • (1996) J. Virol. , vol.70 , pp. 264-271
    • Liu, T.1    Tang, Q.2    Hendricks, R.L.3
  • 30
    • 0028796668 scopus 로고
    • In situ DNA PCR and RNA hybridization detection of herpes simplex virus sequences in trigeminal ganglia of latently infected mice
    • Mehta, A., Maggioncalda, J., Bagasra, O., Thikkavarapu, S., Saikumari, P., Valyi-Nagy, T., Fraser, N. W., and Block, T. M. (1995). In situ DNA PCR and RNA hybridization detection of herpes simplex virus sequences in trigeminal ganglia of latently infected mice. Virology 206, 633-640.
    • (1995) Virology , vol.206 , pp. 633-640
    • Mehta, A.1    Maggioncalda, J.2    Bagasra, O.3    Thikkavarapu, S.4    Saikumari, P.5    Valyi-Nagy, T.6    Fraser, N.W.7    Block, T.M.8
  • 31
    • 0028227879 scopus 로고
    • Herpes simplex virus type 1 DNA persistence, progressive disease, and transgenic immediate early gene promoter activity in chronic corneal infections in mice
    • Mitchell, W. J., Gressens, P., Martin, J. R., and DeSanto, R. (1994). Herpes simplex virus type 1 DNA persistence, progressive disease, and transgenic immediate early gene promoter activity in chronic corneal infections in mice. J. Gen. Virol. 75, 1201-1210.
    • (1994) J. Gen. Virol. , vol.75 , pp. 1201-1210
    • Mitchell, W.J.1    Gressens, P.2    Martin, J.R.3    DeSanto, R.4
  • 32
    • 0029079852 scopus 로고
    • Induction of MHC class I genes in neurons
    • Neumann, H., Cavalie, A., Jenne, D. E., and Wekerle, H. (1995). Induction of MHC class I genes in neurons. Science 269, 549-552.
    • (1995) Science , vol.269 , pp. 549-552
    • Neumann, H.1    Cavalie, A.2    Jenne, D.E.3    Wekerle, H.4
  • 33
    • 0029900012 scopus 로고    scopus 로고
    • Herpes simplex virus gene expression in neurons: Viral DNA synthesis is a critical regulatory element in the branch point between lytic and latent pathways
    • Nichol, P. F., Chang, J.Y., Johnson, E. M., Jr., and Olivo, P. D. (1996). Herpes simplex virus gene expression in neurons: Viral DNA synthesis is a critical regulatory element in the branch point between lytic and latent pathways. J. Virol. 70, 5476-5486.
    • (1996) J. Virol. , vol.70 , pp. 5476-5486
    • Nichol, P.F.1    Chang, J.Y.2    Johnson E.M., Jr.3    Olivo, P.D.4
  • 34
    • 0028285180 scopus 로고
    • Axonal transport of herpes simplex virions to epidermal cells: Evidence for a specialized mode of virus transport and assembly
    • Penford, M. E. T., Armati, P., and Cunningham, A. L. (1994). Axonal transport of herpes simplex virions to epidermal cells: Evidence for a specialized mode of virus transport and assembly. Proc. Natl. Acad. Sci. USA 91, 6529-6532.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 6529-6532
    • Penford, M.E.T.1    Armati, P.2    Cunningham, A.L.3
  • 35
    • 0019933059 scopus 로고
    • Effect of acyclovir on various murine in vivo and in vitro immunologic assay systems
    • Quinn, R. P., Wolberg, G., Medzihradsky, J., and Elion, G. B. (1982). Effect of acyclovir on various murine in vivo and in vitro immunologic assay systems. Am. J. Med. 73, 62-66.
    • (1982) Am. J. Med. , vol.73 , pp. 62-66
    • Quinn, R.P.1    Wolberg, G.2    Medzihradsky, J.3    Elion, G.B.4
  • 36
    • 0028855993 scopus 로고
    • Consequences of cytotoxic T lymphocyte interaction with major histocompatability complex class I-expressing neurons in vivo
    • Rall, G. F., Mucke, L., and Oldstone, M. B. A. (1995). Consequences of cytotoxic T lymphocyte interaction with major histocompatability complex class I-expressing neurons in vivo. J. Exp. Med. 182, 1201-1212.
    • (1995) J. Exp. Med. , vol.182 , pp. 1201-1212
    • Rall, G.F.1    Mucke, L.2    Oldstone, M.B.A.3
  • 37
    • 0028135457 scopus 로고
    • PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant
    • Ramakrishnan, R., Levine, M., and Fink, D. J. (1994). PCR-based analysis of herpes simplex virus type 1 latency in the rat trigeminal ganglion established with a ribonucleotide reductase-deficient mutant. J. Virol. 68, 7083-7091.
    • (1994) J. Virol. , vol.68 , pp. 7083-7091
    • Ramakrishnan, R.1    Levine, M.2    Fink, D.J.3
  • 38
    • 0000595684 scopus 로고    scopus 로고
    • Herpes simplex viruses and their replication
    • (B. N. Fields, D. M. Knipe, and P. M. Howley, Eds.), 3rd ed., Lippincott-Raven, Philadelphia, PA
    • Roizman, B. (1996). Herpes simplex viruses and their replication. In "Virology" (B. N. Fields, D. M. Knipe, and P. M. Howley, Eds.), 3rd ed., pp. 2221-2230. Lippincott-Raven, Philadelphia, PA.
    • (1996) Virology , pp. 2221-2230
    • Roizman, B.1
  • 40
    • 0024310839 scopus 로고
    • An improved model of recurrent herpetic eye disease in mice
    • Shimeld, C., Hill, T., Blyth, B., and Easty, D. (1989). An improved model of recurrent herpetic eye disease in mice. Curr. Eye Res. 8, 1193-1205.
    • (1989) Curr. Eye Res. , vol.8 , pp. 1193-1205
    • Shimeld, C.1    Hill, T.2    Blyth, B.3    Easty, D.4
  • 41
    • 0029084166 scopus 로고
    • Immune cell infiltration and persistence in the mouse trigeminal ganglion after infection of the cornea with herpes simplex virus type 1
    • Shimeld, C., Whiteland, J. L., Nicholls, S. M., Grinfeld, E., Easty, D. L., Gao, H., and Hill, T. J. (1995). Immune cell infiltration and persistence in the mouse trigeminal ganglion after infection of the cornea with herpes simplex virus type 1. J. Neuroimmunol. 61, 7-16.
    • (1995) J. Neuroimmunol. , vol.61 , pp. 7-16
    • Shimeld, C.1    Whiteland, J.L.2    Nicholls, S.M.3    Grinfeld, E.4    Easty, D.L.5    Gao, H.6    Hill, T.J.7
  • 42
    • 0027537214 scopus 로고
    • Comparative activity of pencyclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16
    • Sutton, D., and Boyd, M. R. (1993). Comparative activity of pencyclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16. Antimicrob. Agents Chemother. 37, 642-645.
    • (1993) Antimicrob. Agents Chemother. , vol.37 , pp. 642-645
    • Sutton, D.1    Boyd, M.R.2
  • 43
    • 0028069394 scopus 로고
    • Microtubule polarity in the peripheral processes of trigeminal ganglion cells: Relevance for the retrograde transport of herpes simplex virus
    • Topp, K. S., Meade, L. B., and LeVail, J. H. (1994). Microtubule polarity in the peripheral processes of trigeminal ganglion cells: relevance for the retrograde transport of herpes simplex virus. J. Neurosci. 14, 318-325.
    • (1994) J. Neurosci. , vol.14 , pp. 318-325
    • Topp, K.S.1    Meade, L.B.2    LeVail, J.H.3
  • 44
    • 0026598866 scopus 로고
    • Herpes simplex virus envelopment and maturation studied by fracture label
    • Torri, M. R., Di Lazorro, C., Pavan, A., Pereira, L., and Campadelli-Fiume, G. (1992). Herpes simplex virus envelopment and maturation studied by fracture label. J. Virol. 66, 554-561.
    • (1992) J. Virol. , vol.66 , pp. 554-561
    • Torri, M.R.1    Di Lazorro, C.2    Pavan, A.3    Pereira, L.4    Campadelli-Fiume, G.5
  • 45
    • 0020400003 scopus 로고
    • Spread of virus and distribution of latent infection following ocular herpes simplex in the non-immune and immune mouse
    • Tullo, A. B., Shimeld, C., Blyth, W. A., Hill, T. J., and Easty, D. I. (1982). Spread of virus and distribution of latent infection following ocular herpes simplex in the non-immune and immune mouse. J. Gen. Virol. 63, 95-101.
    • (1982) J. Gen. Virol. , vol.63 , pp. 95-101
    • Tullo, A.B.1    Shimeld, C.2    Blyth, W.A.3    Hill, T.J.4    Easty, D.I.5
  • 46
    • 0021232989 scopus 로고
    • Reactivation of murine latent HSV infection by epinephrine iontophoresis
    • Willey, D. E., Trousdale, M. D., and Nesburn, A. B. (1984). Reactivation of murine latent HSV infection by epinephrine iontophoresis. Invest. Ophthal. Vis. Sci. 25, 945-950.
    • (1984) Invest. Ophthal. Vis. Sci. , vol.25 , pp. 945-950
    • Willey, D.E.1    Trousdale, M.D.2    Nesburn, A.B.3
  • 47
    • 0029065431 scopus 로고
    • Randomised comparison of ganciclovir and high dose acyclovir for long-term cytomegalovirus prophylaxis in liver transplant recipients
    • Winston, D. J., Wirin, D., Shaked, A., and Busuttil, R. W. (1995). Randomised comparison of ganciclovir and high dose acyclovir for long-term cytomegalovirus prophylaxis in liver transplant recipients. Lancet 346, 69-74.
    • (1995) Lancet , vol.346 , pp. 69-74
    • Winston, D.J.1    Wirin, D.2    Shaked, A.3    Busuttil, R.W.4
  • 48
    • 0028258524 scopus 로고
    • Effects of high-dose oral acyclovir on herpesvirus disease and survival in patients with advanced HIV disease: A double blind, placebo-controlled study
    • Youle, M. S., Gazzard, B. G., Johnson, M. A., Cooper, D. A., Hoy, J. F., Busch, H., Ruf, B., Griffiths, P. D., Stephenson, S. L., Dancos, M., and Bell, A. R. (1994). Effects of high-dose oral acyclovir on herpesvirus disease and survival in patients with advanced HIV disease: A double blind, placebo-controlled study. AIDS 8, 641-649.
    • (1994) AIDS , vol.8 , pp. 641-649
    • Youle, M.S.1    Gazzard, B.G.2    Johnson, M.A.3    Cooper, D.A.4    Hoy, J.F.5    Busch, H.6    Ruf, B.7    Griffiths, P.D.8    Stephenson, S.L.9    Dancos, M.10    Bell, A.R.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.