A role for p53 in DNA end rejoining by human cell extracts

Mutation Research - DNA Repair

Volumn 385, Issue 1, 1997, Pages 21-29

  Bill, Colin A ^a   Yu, Yongjia ^a   Miselis, Nathan R ^a   Little, John B ^a   Nickoloff, Jac A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

DNA end rejoining; Human cell extracts; Lymphoblastoid cells; p53

Indexed keywords

DOUBLE STRANDED DNA; PLASMID DNA; PROTEIN KINASE; PROTEIN P53;

BACTERIUM TRANSFORMATION; DIPLOIDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; GENE MUTATION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR SUPPRESSOR GENE;

CELL EXTRACTS; CELL LINE; DNA REPAIR; HUMANS; LYMPHOCYTES; NUCLEIC ACID CONFORMATION; PLASMIDS; SEQUENCE DELETION; TUMOR SUPPRESSOR PROTEIN P53;

BACTERIA (MICROORGANISMS);

EID: 0030667201     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(97)00040-2     Document Type: Review

References (58)

1. Amundson S.A., Xia F., Wolfson K., Liber H.L. Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor. Mutation Res. 286:1993;233-241.
2. Bakalkin G., Yakovleva T., Selivanova G., Magnusson K.P., Szekely L., Kiseleva E., Klein G., Terenius L., Wiman K.G. p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer. Proc. Natl. Acad. Sci. USA. 91:1994;413-417.
3. Bollag R.J., Waldman A.S., Liskay R.M. Homologous recombination in mammalian cells. Annu. Rev. Genet. 23:1989;199-225.
4. Clarke A.R., Purdie C.A., Harrison D.J., Morris A.G., Hooper M.L., Wyllie A.H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature. 362:1993;849-852.
5. Conley E.C., Saunders J.R. Recombination-dependent recircularization of linearized pBR322 plasmid DNA following transformation of Escherichia coli. Mol. Gen. Genet. 194:1984;211-218.
6. Conley E.C., Saunders V.A., Jackson V., Saunders J.R. Mechanism of intramolecular recyclization and deletion formation following transformation of Escherichia coli with linearized plasmid DNA. Nucleic Acids Res. 14:1986;8919-8932.
7. Conley E.C., Saunders V.A., Saunders J.R. Deletion and rearrangement of plasmid DNA during transformation of Escherichia coli with linear plasmid molecules. Nucleic Acids Res. 14:1986;8905-8917.
8. Cox L.S., Hupp T., Midgley C.A., Lane D.P. A direct effect of activated human p53 on nuclear DNA replication. EMBO J. 14:1995;2099-2105.
9. Davidoff A.M., Iglehart J.D., Marks J.R. Immune response to p53 is dependent on p53/HSP70 complexes in breast cancers. Proc. Natl. Acad. Sci. USA. 89:1992;3439-3442.
10. Deppert W. The yin and yang of p53 in cellular proliferation. Semin. Cancer Biol. 5:1994;187-202.
11. Derbyshire M.K., Epstein L.H., Young C.S.H., Munz P.L., Fishel R. Nonhomologous recombination in human cells. Mol. Cell. Biol. 14:1994;156-169.
12. El-Deiry W.S., Tokino T., Velculescu V.E., Levy D.B., Parson R., Trent J.M., Lin D., Mercer W.E., Kinzler K.W., Vogelstein B. WAF-1, a potential mediator of p53 tumor suppression. Cell. 75:1993;817-825.
13. Fairman M.P., Johnson A.P., Thacker J. Multiple components are involved in the efficient joining of double-stranded DNA breaks in human cell extracts. Nucleic Acids Res. 20:1992;4145-4152.
14. Ganesh A., North P., Thacker J. Repair and misrepair of site-specific DNA double-strand breaks by human cell extracts. Mutation Res. 299:1993;251-259.
15. Harper J.W., Adami G.R., Wei N., Keyomarsi K., Elledge S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:1993;805-816.
16. Harvey M., Sands A.T., Weiss R.S., Hegi M.E., Wiseman R.W., Pantazis P., Giovanella B.C., Tainshi M.A., Bradley A., Donehower L.A. In vitro growth characteristics of embryo fibroblasts isolated from p53-deficient mice. Oncogene. 8:1993;2457-2467.
17. Havre P.A., Yuan J., Hedrick L., Cho K.R., Glazer P.M. p53 inactivation by HPV 16 E6 results in increased mutagenesis in human cells. Cancer Res. 55:1995;4420-4424.
18. Ishizaki K., Ejima Y., Matsunaga T., Hara R., Sakamoto A., Ikenaga M., Ikawa Y., Aizewa S. Increased UV-induced SCEs but normal repair of DNA damage in p53-deficient mouse cells. Int. J. Cancer. 58:1994;254-257.
19. Johnson A.P., Fairman M.P. The identification and characterization of mammalian proteins involved in the rejoining of DNA double-strand breaks in vitro. Mutation Res. 364:1996;103-116.
20. Kastan M.B., Onyekwere O., Sidransky D., Vogelstein B., Craig R.W. Participation of p53 protein in the cellular response to DNA damage. Cancer Res. 51:1991;6304-6311.
21. Kessis T.D., Slebos R.J., Nelson W.G., Kastan M.B., Plunkett B.S., Han S.M., Lorincz A.T., Hedrick L., Cho K.R. Human papillomavirus 16 E6 expression disrupts the p535-mediated cellular response to DNA damage. Proc. Natl. Acad. Sci. USA. 90:1993;3988-3992.
22. Lehman C.W., Trautman J.K., Carroll D. Illegitimate recombination in Xenopus: characterization of end-joined junctions. Nucleic Acids Res. 22:1994;434-442.
23. Levine A.J. The tumor suppressor genes. Annu. Rev. Biochem. 62:1993;623-651.
24. 1 arrest in two closely related human lymphoblast cell lines that differ in p53 status. J. Biol. Chem. 270:1995;11033-11036.
25. Livingstone L.R., White R.A., Sprouse J., Livanos E., Jacks T., Tlsty T.D. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell. 70:1992;923-935.
26. Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362:1993;847-849.
27. Manley J.L., Fire A., Samuels M., Sharp P.A. In vitro transcription: whole-cell extract. Methods Enzymol. 101:1983;568-583.
28. Mekeel K.L., Tang W., Kachnic L.A., Luo C.M., Defrank J.S., Powell S.N. Inactivation of p53 results in high-rates of homologous recombination. Oncogene. 14:1997;1847-1857.
29. Miyashita T., Krajewski S., Krajewska M., Wang H.G., Lin H.K., Libermann D.A., Hoffman B., Reed J.C. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 9:1994;1799-1805.
30. Nelson W.G., Kastan M.B. DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol. Cell. Biol. 14:1994;1815-1823.
31. Nickoloff J.A. Sepharose spin column chromatography: a fast, nontoxic replacement for phenol:chloroform extraction/ethanol precipitation. Mol. Biotech. 1:1994;105-108.
32. Nicolas A.P., Munz P.L., Young C.S.H. A modified single-strand annealing model best explains the joining of DNA double-strand breaks in mammalian cells and cell extracts. Nucleic Acids Res. 23:1995;1036-1043.
33. Nicolas A.P., Young C.S.H. Characterization of DNA end joining in a mammalian cell nuclear extract: junction formation is accompanied by nucleotide loss, which is limited and uniform but not site specific. Mol. Cell. Biol. 14:1994;170-180.
34. North P., Ganesh A., Thacker J. The rejoining of double-strand breaks in DNA by human cell extracts. Nucleic Acids Res. 18:1990;6205-6210.
35. Oberosler P., Hloch P., Ramsperger U., Stahl H. p53-catalyzed annealing of complementary single-stranded nucleic acids. EMBO J. 12:1993;2389-2396.
36. Pavletich N.P., Chambers K.A., Pabo C.O. The DNA-binding domain of p53 contains four conserved regions and the major mutation hot spots. Genes Dev. 7:1993;2556-2564.
37. Pfeiffer P., Thode S., Hancke J., Vielmetter W. Mechanisms of overlap formation in nonhomologous DNA end joining. Mol. Cell. Biol. 14:1994;888-895.
38. Pfeiffer P., Vielmetter W. Joining of nonhomologous DNA double-strand breaks in vitro. Nucleic Acids Res. 16:1988;907-924.
39. Reed M., Woelker B., Wang P., Anderson M.E., Tegtmeryer P. The C-terminal domain of p53 recognizes DNA damaged by ionizing radiation. Proc. Natl. Acad. Sci. USA. 92:1995;9455-9459.
40. Roth D.B., Lindahl T., Gellert How to makes ends meet. Curr. Biol. 5:1995;496-499.
41. Roth D.B., Wilson J.H. Non-homologous recombination in mammalian cells: role for short sequence homologies in the joining reaction. Mol. Cell. Biol. 6:1986;4295-4304.
42. Schulte-Frohlinde D., Worm K.H., Merz M. Double-strand breaks in plasmid DNA and the induction of mutations. Mutation Res. 299:1993;233-250.
43. Smith M.L., Chen I.-T., Zhan Q., O'Connor P.M., Fornace A.J. Involvement of the p53 tumor suppressor in repair of UV-type DNA damage. Oncogene. 10:1995;1053-1059.
44. Steinmayer K., Deppert W. DNA binding properties of murine p53. Oncogene. 3:1988;501-507.
45. Sturzbecher H.-W., Donzelman B., Henning W., Knippschild U., Buchhop S. p53 is linked directly to homologous recombination processes via RAD1/RecA protein interaction. EMBO J. 15:1996;1992-2002.
46. Su L.-N., Little J.B. Transformation and radiosensitivity of human diploid skin fibroblasts transfected with SV40 T-antigen mutants defective in RB and p53 binding domains. Int. J. Radiat. Biol. 62:1992;461-468.
47. Thacker J., Chalk J., Ganesh A., North P. A mechanism for deletion formation in DNA by human cell extracts: the involvement of short sequence repeats. Nucleic Acids Res. 20:1992;6183-6188.
48. Tsang N.-M., Nagasawa H., Li C., Little J.B. Abrogation of p53 function by transfection of HPV 16 E6 gene enhances the resistance of human diploid fibroblasts to ionizing radiation. Oncogene. 10:1995;2403-2408.
49. Wang X.W., Yeh H., Schaeffer L., Roy R., Moncollin V., Egly J.-M., Wang Z., Friedberg E.C., Evans M.K., Taffe B.G., Bohr V.A., Weeda G., Hoeijmakers J.H.J., Forrester K., Harris C. p53 modulation of TFIIH-associated nucleotide excision repair activity. Nature Genet. 10:1995;188-195.
50. Wang Z., Rossman T.G. Large-scale supercoiled plasmid preparation by acidic phenol extraction. Biotechniques. 16:1994;460-463.
51. Ward, J., 1997. The nature of lesions formed by ionizing radiation. In: Nickoloff, J.A., Hoekstra, M.F. (Eds.), DNA Damage and Repair. Humana Press, Totowa, NJ, in press.
52. Wiesmuller L., Cammenga J., Deppert W.W. In vivo assay of p53 function in homologous recombination between simian virus 40 chromosomes. J. Virol. 70:1996;737-744.
53. Wu L., Bayle J.H., Elenbaas B., Pavletich N.P., Levine A.J. Alternatively spliced forms in the carboxy-terminal domain of the p53 protein regulate its ability to promote annealing of complementary single strands of nucleic acids. Mol. Cell. Biol. 15:1995;497-504.
54. Xia F., Amundson S.A., Nickoloff J.A., Liber H.L. Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation. Mol. Cell. Biol. 14:1994;5850-5857.
55. Xia F., Wang X., Tsang N.-M., Yandell D.W., Kelsey K.T., LIber H.L. Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer Res. 55:1995;12-15.
56. Yin Y., Tainsky M.A., Bischoff F.Z., Strong L.C., Wahl G.M. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell. 70:1992;937-948.
57. Yu Y., Li C.Y., Little J.B. Abrogation of p53 function by HPV 16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in human TK6 human lymphoblast cells. Oncogene. 14:1997;1661-1667.
58. Zhan Q., Lord K.A., Alamo I. Jr., Hollander M.C., Carrier F., Ron D., Kohn K.W., Hoffman B., Liebermann D.A., Fornace A.J. Jr. The GADD and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth. Mol. Cell. Biol. 14:1994;2361-2371.