A critical role for antigen-specific Th1 cells in acute liver injury in mice

Journal of Immunology

Volumn 162, Issue 11, 1999, Pages 6503-6509

  Nishimura, Takashi ^a   Ohta, Akio ^a  

^a TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 4;

ACUTE DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; IMMUNOMODULATION; IMMUNOREACTIVITY; LIVER INJURY; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ACUTE DISEASE; ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, CD95; DISEASE MODELS, ANIMAL; EPITOPES, T-LYMPHOCYTE; FAS LIGAND PROTEIN; FEMALE; HEPATITIS B SURFACE ANTIGENS; HEPATITIS, ANIMAL; LIGANDS; LIPOSOMES; LIVER; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED MRL LPR; MICE, NUDE; MICE, TRANSGENIC; OVALBUMIN; TH1 CELLS;

EID: 0033153506     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Chisari, F. V. 1997. Cytotoxic T cells and viral hepatitis. J. Clin. Invest. 99:1472.
2. Milich, D. R. 1997. Influence of T-helper cell subsets and crossregulation in hepatitis B virus infection. J. Viral Hepat. 4:48.
3. Imada, K., Y. Fukuda, Y. Koyama, I. Nakano, M. Yamada, Y. Katano, and T. Hayakawa. 1997. Naive and memory T cell infiltrates in chronic hepatitis C: phenotypic changes with interferon treatment. Clin. Exp. Immunol. 109:59.
4. Tanaka, A., S. Iwabuchi, M. Takatori, A. Ohno, H. Yamada, N. Hashimoto, Y. Ikeda, T. Kato, K. Nashioka, S. Iino, and K. Yamamoto. 1997. Clonotypic analysis of T cells in patients with autoimmune and viral hepatitis. Hepatology 25:1070.
5. Vingerhoets, J., P. Michielsen, G. Vanham, E. Bosmans, W. Paulij, A. Ramon, P. Pelckmans, L. Kestens, and G. Leroux-Roels. 1998. HBV-specific lymphoproliferative and cytokine responses in patients with chronic hepatitis B. J. Hepatol. 28:8.
6. Lohse, A. W., M. Manns, H. P. Dienes, K. H. Meyer zum Buschenfelde, and I. R. Cohen. 1990. Experimental autoimmune hepatitis: disease induction, time course and T-cell reactivity. Hepatology 11:24.
7. Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90:196.
8. Ando, K., T. Moriyama, L. G. Guidotti, S. Wirth, R. D. Schreiber, H. J. Schlicht, S.-N. Huang, and F. V. Chisari. 1993. Mechanisms of class I restricted immunopathology: a transgenic mouse model of fulminant hepatitis. J. Exp. Med. 178: 1541.
9. Tanaka, Y., A. Takahashi, K. Kobayashi, I. Aral, S. Higuchi, S. Otomo, K. Watanabe, S. Habu, and T. Nishimura. 1995. Establishment of a T cell-dependent nude mouse liver injury model induced by Propionibacterium acnes and LPS. J. Immunol. Methods 182:21.
10. Franco, A., L. G. Guidotti, M. V. Hobbs, V. Pasquetto, and F. V. Chisari. 1997. Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. J. Immunol. 159:2001.
11. Gantner, F., M. Leist, A. W. Lohse, P. G. Germann, and G. Tiegs. 1995. Concanavalin A-induced T cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21:190.
12. Kusters, S., F. Gantner, G. Kunstle, and G. Tiegs. 1996. Interferon γ plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 111:462.
13. Tiegs, G. 1997. Experimental hepatitis and role of cytokines. Ada Gastroenterol. Belg. 60:176.
14. Tanaka, Y., A. Takahashi, K. Watanabe, K. Takayama, T. Yahata, S. Habu, and T. Nishimura. 1996. A pivotal role of IL-12 in Th1-dependent mouse liver injury. Int. Immunol. 8:569.
15. Mosmann, T. R., and R. L. Coffman. 1989. Th1 and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
16. O'Garra, A. 1998. Cytokines induce the development of functionally heterogenous T helper cell subsets. Immunity 8:275.
17. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol. Today 16:34.
18. O'Garra, A., and K. M. Murphy. 1995. T-cell subsets in autoimmunity. Curr. Opin. Immunol. 5:880.
19. Watanabe, Y., M. Morita, and T. Alcaike. 1996. Concanavalin A induces perforinmediated but not Fas-mediated hepatic injury. Hepatology 24:702.
20. Lafaille, J. J., F. V. Keere, A. L. Hsu, J. L. Baron, W. Haas, C. S. Raine, and S. Tonegawa. 1997. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186:307.
21. Tian, J., A. P. Olcott, L. R. Hanssen, D. Zekzer, B. Middleton, and D. L. Kaufman. 1998. Infectious Th1 and Th2 autoimmunity in diabetes-prone mice. Immunol. Rev. 164:119.
22. lo thymocytes in vivo. Science 250: 1720.
23. Lowry, O. H., N. J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265.
24. Gavrieli, Y., Y. Sherman, and S. A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493.
25. Kingston, D., and J. R. Pearson. 1981. The use of the peroxidase reaction to obliterate staining of eosinophils by fluorescent-labelled conjugates. J. Immunol. Methods 44:191.
26. Hinkle, G. H., G. S. Born, W. Kessler, and S. M. Shaw. 1978. Preferential localization of radiolabeled liposomes in liver. J. Pharm. Sci. 67:795.
27. Gilles, P. N., D. L. Guerrette, R. J. Ulevitch, R. D. Schreiber, and F. V. Chisari. 1992. HBsAg retention sensitizes the hepatocytes to injury by physiological concentrations of interferon-γ. Hepatology 16:655.
28. Harada, K., J. Van de Water, P. S. Leung, R. L. Coppel, A. Ansari, Y. Nakanuma, and M. E. Gershwin. 1997. In situ nucleic acid hybridization of cytokines in primary biliary cirrhosis: predominance of the Th1 subset. Hepatology 25:791.
29. Napoli, J., G. A. Bishop, P. H. McGuinness, D. M. Painter, and G. W. McCaughan. 1996. Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology 24:759.
30. Rossol, S., G. Marines, P. Carucci, M. V. Singer, R. Williams, and N. V. Naoumov. 1997. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J. Clin. Invest. 99:3025.
31. Ohta, A., N. Sato, T. Yahata, Y. Ohmi, K. Santa, T. Sato, H. Tashiro, S. Habu, and T. Nishimura. 1997. Manipulation of Th1/Th2 balance in vivo by adoptive transfer of antigen-specific Th1 or Th2 cells. J. Immunol. Methods 209:85.
32. 32: Fortin, A., E. Shahum, K. Krzystyniak, and H. M. Therien. 1996. Differential activation of cell-mediated immune functions by encapsulated and surface-linked tiposomal antigens. Cell. Immunol. 169:208.
33. -/- mice: role for IFN-γ in activating apoptosis of hepatocytes. J. Immunol. 159:1418.
34. Talmadge, J. E., O. Bowersox, H. Tribble, S. H. Lee, H. M. Shepard, and D. Liggitt. 1987. Toxicity of tumor necrosis factor is synergistic with γ-interferon and can be reduced with cyclooxygenase inhibitors. Am. J. Pathol. 128:410.
35. Adamson, G. M., and R. E. Billings. 1993. Cytokine toxicity and induction of NO synthase activity in cultured mouse hepatocytes. Toxicol. Appl. Pharmacol. 119: 100.
36. + T cells for concanavalin A-induced hepatic injury in mice. J. Immunol. 159:1537.
37. Nagakawa, J., I. Hishinuma, K. Hirota, K. Miyamoto, T. Yamanaka, K. Tsukida, K. Katayama, and I. Yamatsu. 1990. Involvement of tumor necrosis factor-α in the pathogenesis of activated-macrophage-mediated hepatitis in mice. Gastroenterology 99:758.
38. Kondo, T., T. Suda, H. Fukuyama, M. Adachi, and S. Nagata. 1997. Essential role of the Fas ligand in the development of hepatitis. Nat. Med. 3:409.
39. Seino, K., N. Kayagaki, K. Takeda, K. Fukao, K. Okumura, and H. Yagita. 1997. Contribution of Fas ligand to T cell-mediated hepatic injury in mice. Gastroenterology 113:1315.
40. Ksontini, R., D. B. Colagiovanni, M. D. Josephs, C. K. Edwards III, C. L. Tannahill, C. C. Solorzano, J. Norman, W. Denham, M. Clare-Salzler, S. L. D. MacKay, and L. L. Moldawer. 1998. Disparate roles for TNF-α and Fas ligand in concanavalin A-induced hapatilis. J. Immunol. 160:4082.
41. Nakamoto, Y., L. G. Guidotti, V. Pasquetto, R. D. Schreiber, and F. V. Chisari. 1997. Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice. J. Immunol. 158:5692.
42. Kataoka, T., N. Shinohara, H. Takayama, K. Takaku, S. Kondo, S. Yonehara, and K. Nagai. 1996. Concanamycin A, a powerful tool for characterization and estimation of contribution of perform-and Fas-based lytic pathways in cell-mediated cytotoxicity. J. Immunol 156:3678.
43. Mizuhara, H., M. Kuno, N. Seki, W.-G. Yu, M. Yamaoka, M. Yamashita, T. Ogawa, K. Kaneda, T. Fujii, H. Senoh, and H. Fujiwara. 1998. Strain difference in the induction of T-cell activation-associated, interferon γ-dependent hepatic injury in mice. Hepatology 27:513.
44. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
45. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
46. Shankar, A. H., and R. G. Titus. 1995. T cell and non-T cell compartments can independently determine resistance to Leishmania major. J. Exp. Med. 181:845.
47. Guler, M. L., N. G. Jacobson, U. Gubler, and K. M. Murphy. 1997. T cell genetic background determines maintenance of IL-12 signaling: effects on BALB/c and B10.D2 T helper cell type 1 phenotype development. J. Immunol. 159:1767.
48. - T cells in non-MHC gene-controlled predisposition toward skewing into T helper type-2 immunity in BALB/c mice. J. Immunol. 158:5698.