Sulfonamide-induced reactions in desensitized patients with AIDS-The role of covalent protein haptenation by sulfamethoxazole

Journal of Allergy and Clinical Immunology

Volumn 101, Issue 3, 1998, Pages 371-378

  Gruchalla, Rebecca S ^a,c   Pesenko, Richard D ^a   Do, Thinh T ^b   Skiest, Daniel J ^b  

^a Division of Allergy and Immunology   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

AIDS; Desensitization; Haptenation; Prophylaxis; Sulfamethoxazole

Indexed keywords

SULFAMETHOXAZOLE; SULFONAMIDE;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIBIOTIC PROPHYLAXIS; ANTIGEN RECOGNITION; ARTICLE; CASE REPORT; DESENSITIZATION; DRUG HYPERSENSITIVITY; DRUG PROTEIN BINDING; HUMAN; PRIORITY JOURNAL;

EID: 0031895436     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-6749(98)70250-7     Document Type: Article

References (54)

1. Carr A, Swanson C, Penny R, Cooper DA. Clinical and laboratory markers of hypersensitivity to trimethoprim-sulfamethoxazole in patients with Pneumocystis carinii pneumonia and AIDS. J Infect Dis 1993;167:180-5.
2. Hennessy S, Strom BL, Berlin JA, Brennan PJ. Predicting cutaneous hypersensitivity reactions to cotrimoxazole in HIV-infected individuals receiving primary Pneumocystis carinii pneumonia prophylaxis. J Gen Intern Med 1995;10:380-6.
3. Roujeau JC, Stern RS. Severe adverse cutaneous reactions to drugs. N Engl J Med 1994;19:1272-85.
4. Lanctôt K, Ghajar BM, Shear NH, Naranjo CA. Improving the diagnosis of hypersensitivity reactions associated with sulfonamides. J Clin Pharmacol 1994;34:1228-33.
5. Carr A, Penny R, Cooper DA. Efficacy and safety of rechallenge with low-dose trimethoprim-sulphamethoxazole in previously hypersensitive HIV-infected patients. AIDS 1993;7:65-71.
6. Coopman SA, Johnson RA, Platt R, Stern RS. Cutaneous disease and drug reactions in HIV infection. N Engl J Med 1993;328:1670-4.
7. van der Ven AJM, Koopmans PP, Vree TB, Van Der Meer JWM. Drug intolerance in HIV disease. J Antimicrob Chemother 1994;34:1-5.
8. Arnold PA, Guglielmo BJ, Hollander H. Severe hypersensitivity reaction upon rechallenge with trimethoprim-sulfamethoxazole in a patient with AIDS. Drug Intelligence and Clinical Pharmacology 1988;22:43-5.
9. Gordin FM, Simon GL, Wofsy CB, Mills J. Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. Ann Intern Med 1984;100:495-9.
10. Bayard PJ, Berger TG, Jacobson MA. Drug hypersensitivity reactions and human immunodeficiency virus disease. J Acquir Immune Defic Syndr 1992;5:1237-57.
11. Koopmans PP, van der Ven A, Vree TB, Van der Meer J. Pathogenesis of hypersensitivity reactions to drugs in patients with HIV infection: allergic or toxic? AIDS 1995;9:217-22.
12. Lee BL, Safrin S. Interactions and toxicities of drugs used in patients with AIDS. Clin Infect Dis 1992;14:773-9.
13. Carr A, Cooper DA, Penny R. Allergic manifestations of human immunodeficiency virus (HIV) infection. J Clin Immunol 1991;11:55-64.
14. Greenberger PA, Patterson R. Management of drug allergy in patients with acquired immunodeficiency syndrome. J Allergy Clin Immunol 1987;79:484-8.
15. Shear NH, Spielberg SP, Grant DM, Tang BK, Kalow W. Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity. Ann Intern Med 1986; 105:179-84.
16. Carr A, Tindall B, Penny R, Cooper DA. In vitro cytotoxicity as a marker of hypersensitivity to sulphamethoxazole in patients with HIV. Clin Exp Immunol 1993;94:21-5.
17. Epstein M, Wright JM. Severe multisystem disease caused by trimethoprim-sulfamethoxazole: possible role of an in vitro lymphocyte assay. J Allergy Clin Immunol 1989;86:416-7.
18. Meekins CV, Sullivan TJ, Gruchalla RS. Immunochemical analysis of sulfonamide drug allergy: identification of sulfamethoxazole-substituted human serum proteins. J Allergy Clin Immunol 1994;94:1017-24.
19. Carrington DM, Earl HS, Sullivan TJ. Studies of human IgE to a sulfonamide determinant. J Allergy Clin Immunol 1987;79:442-7.
20. Gruchalla RS, Sullivan TJ. In vitro and in vivo studies of immunologic reactivity to sulfamethoxazole [abstract]. J Allergy and Clin Immunol 1990;35:157.
21. Gruchalla RS, Sullivan TJ. Detection of human IgE to sulfamethoxazole by skin testing with sulfamethoxazole poly-L-tyrosine. J Allergy Clin Immunol 1991;88:784-92.
22. Harle DG, Baldo BA, Wells JV. Drugs as allergens: detection and combining site specificities of IgE antibodies to sulfamethoxazole. Mol Immunol 1988;25:1347-54.
23. Daftarian MF, Filion LG, Cameron W, Conway B, Roy R, Tropper F, et al. Immune response to sulfamethoxazole in patients with AIDS. Clin Diagn Lab Immunol 1995;2:199-204.
24. O'Neil CE, Reed MA, Lopez M, Hyslop N, Gutierrez E, Salvaggio J. Evaluation of immune parameters in HIV+ subjects reporting adverse reactions to sulfamethoxazole. Int Arch Allergy Appl Immunol 1991;94:246-7.
25. Kiefel V, Santoso S, Schmidt S, Salama A, Mueller-Eckhardt C. Metabolite-specific (IgG) and drug-specific antibodies (IgG, IgM) in two cases of trimethoprim-sulfamethoxazole-induced immune thrombocytopenia. Transfusion 1987;27:262-5.
26. Warrington RJ, Sauder PJ, McPhillips S. Lymphocyte transformation studies in suspected hypersensitivity to trimethoprim-sulfamethoxazole. Clin Allergy 1983;13:235-40.
27. Cribb AE, Spielberg SP. Hepatic microsomal metabolism of sulfamethoxazole to the hydroxylamine. Drug Metab Dispos 1990;18:784-7.
28. Rieder MJ, Uetrecht J, Shear NH, Spielberg SP. Diagnosis of sulfonamide hypersensitivity reactions by in vitro rechallenge with hydroxylamine metabolites. Ann Intern Med 1989;110:286-9.
29. Rieder MJ, Uetrecht JM, Shear NH, Spielberg SP. Synthesis and in vitro toxicity of hydroxylamine metabolites of sulfonamides. J Pharmacol Exp Ther 1988;244:724-8.
30. Shear NH, Spielberg SP. In vitro evaluation of a toxic metabolite of sulfadiazine. Can J Physiol Pharmacol 1985;63:1370-2.
31. Kenna JG. The molecular basis of halothane-induced hepatitis. Biochem Soc Trans 1990;19:191-5.
32. Satoh H, Gillette JR, Davies HW, Schulick RD, Pohl LR. Immunochemical evidence of trifluoroacetylated cytochrome P-450 in the liver of halothane-treated rats. Mol Pharmacol 1985;28:468-74.
33. Beaune P, Dansette PM, Mansuy D, Kiffel L, Finck M, Amar L, et al. Human anti-endoplasmic reticulum autoantibodies appearing in drug-induced hepatitis are directed against a human liver cytochrome P-450 that hydroxylates the drug. Proc Natl Acad Sci USA 1987;84:551-5.
34. Martin JL, Kenna JG, Martin BM, Thomassen D, Reed OF, Pohl LR. Halothane hepatitis patients have serum antibodies that react with protein disulfide isomerase. Hepatology 1993;858-63.
35. Satoh H, Fukuda Y, Anderson DK, Ferrans VJ, Gillette JR, Pohl LR. Immunological studies on the mechanism of halothane-induced hepatotoxicity: immunohistochemical evidence of trifluoroacetylated hepatocytes. J Pharmacol Exp Ther 1985;233:857-62.
36. Kenna JG, Neuberger J, Williams R. Evidence for expression in human liver of halothane-induced neoantigens recognized by antibodies in sera from patients with halothane hepatitis. Hepatology 1988;8:1635-41.
37. Vergani D, Mieli-Vergani G, Albert! A, Neuberger J, Eddleston AL, Davis M, et al. Antibodies to the surface of halothane-altered rabbit hepatocytes in patients with severe halothane-associated hepatitis. N Engl J Med 1980;303:66-71.
38. Kenna JG, Satoh H, Christ DD, Pohl LR. Metabolic basis for a drug hypersensitivity: antibodies in sera from patients with halothane hepatitis recognized liver neoantigens that contain the trifluoroacetyl group derived from halothane. J Pharmacol Exp Ther 1988;245:1103-9.
39. Kenna JG, Neuberger J, Williams R. Identification by immunoblotting of three halothane-induced liver microsomal polypeptide antigens recognized by antibodies in sera from patients with halothane-associated hepatitis. J Pharmacol Exp Ther 1987;242:733-40.
40. Macy E, Kemeny M, Saxon A. Enhanced ELISA: how to measure less than 10 picograms of a specific protein (immunoglobulin) in less than 8 hours. FASEB J 1988;2:3003-9.
41. Laemmli UK. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4. Nature 1970;227:680-5.
42. Absar N, Daneshvar H, Beall G. Desensitization to trimethoprim/sulfamethoxazole in HIV-infected patients. J Allergy Clin Immunol 1994;93:1001-5.
43. Sattier FR, Cowan R, Nielson DM, Ruskin J. Trimethoprimsulfamethoxazole with pentamidine for treatment of Pneumocystis cannii pneumonia in the Acquired Immunodeficiency Syndrome. Ann Intern Med 1988;109:280-7.
44. Rieder M, Shear NH, Kanee A, Tang BK, Spielberg SP. Prominence of slow acetylator phenotype among patients with sulfonamide hypersensitivity reactions. Clin Pharmacol Ther 1991;49:13-7.
45. Carr A, Gross AS, Hoskins JM, Penny R, Cooper DA. Acetylation phenotype and cutaneous hypersensitivity to trimethoprim-sulphamethoxazole in HIV-infected patients. AIDS 1994,8:333-7.
46. Lee BL, Wong D, Benowitz NL, Sullam PM. Altered patterns of drug metabolism in patients with acquired immunodeficiency syndrome. Clin Pharmacol Ther 1993;53:529-35.
47. Droge W. Cysteine and glutathione deficiency in AIDS patients: a rationale for the treatment with N-acetyl-cysteine. Pharmacology 1993;46:61-5.
48. Battegay M, Opravil M, Wuthrich B, Luthy R. Rash with amoxycillin clavulanate therapy in HIV-infected patients [letter]. Lancet 1989;2:1100.
49. Wright DN, Nelson RP, Ledford DK, Fernandez-Caldas E, Trudeau WL, Lockey RF. Serum IgE and human immunodeficiency virus infection. J Allergy Clin Immunol 1990;85:445-52.
50. Lee BL, Delahunty T, Safrin S. The hydroxylamine of sulfamethoxazole and adverse reactions in patients with acquired immunodeficiency syndrome. Clin Pharmacol Ther 1994;56:184-9.
51. Coeshott C, Cook C, Ohnemus C, Burman W, Caraway P, Cohn D, et al. Sulfamethoxazole-specific antibodies in patients with AIDS: a prospective study [abstract]. J Allergy Clin Immunol 1996;97:346.
52. Kalish RS, LaPorte A, Wood JA, Johnson KL. Sulfonamide-reactive lymphocytes detected at very low frequency in the peripheral blood of patients with drug-induced eruptions. J Allergy Clin Immunol 1994;94:465-72.
53. Mauri-Hellweg D, Bettens F, Mauri D, Brander C, Hunziker T, Pichler W. Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin and carbamazepine. J Immunol 1995;155:462-72.
54. Carr A, Vasak E, Munro V, Penny R, Cooper DA. Immunohistological assessment of cutaneous drug hypersensitivity in patients with HIV infection. Clin Exp Immunol 1994;97:260-5.