Indispensable role for TNF-α and IFN-γ at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen

Journal of Immunology

Volumn 165, Issue 2, 2000, Pages 956-961

  Ohta, Akio ^a   Sekimoto, Masashi ^a   Sato, Marimo ^a,b   Koda, Toshiaki ^a   Nishimura, Shin Ichiro ^a   Iwakura, Yoichiro ^c   Sekikawa, Kenji ^d   Nishimura, Takashi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d NATIONAL INSTITUTE OF ANIMAL HEALTH   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

FAS ANTIGEN; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR; HEPATITIS B SURFACE ANTIGEN; MONOCLONAL ANTIBODY; PERFORIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LIVER INJURY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TH1 CELL;

EID: 0034661995     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.2.956     Document Type: Article

References (39)

1. Chisari, F. V. 1997. Cytotoxic T cells and viral hepatitis. J. Clin. Invest. 99: 1472.
2. Milich, D. R. 1997. Influence of T-helper cell subsets and crossregulation in hepatitis B virus infection. J. Viral Hepatitis 4:48.
3. Rossol, S., G. Marinos, P. Carucci, M. V. Singer, R. Williams, and N. V. Naoumov. 1997. Interleukin-12 induction of Th1 cytokines is important for viral clearance in chronic hepatitis B. J. Clin. Invest. 99:3025.
4. Tsai, S. L., Y. F. Liaw, M. H. Chen, C. Y. Huang, and G. C. Kuo. 1997. Detection of type 2-like T-helper cells in hepatitis C virus infection: implications for hepatitis C virus chronicily. Hepatology 25:449.
5. Penna, A., G. Del Prete, A. Cavalli, A. Bertoletti, M. M D'Elios, R. Sorrentino, M. D'Amato, C. Boni, M. Pilli, F. Fiaccadori, and C. Ferrari. 1997. Predominant T-helper 1 cytokine profile of hepatitis B virus nucleocapsid-specific T cells in acute self-limited hepatitis B. Hepatology 25:1022.
6. Livingston, B. D., J. Alexander, C. Crimi, C. Oseroff, E. Celis, K. Daly, L. G. Guidotti, F. V. Chisari, J. Fikes, R. W. Chesnut, and A. Sette. 1999. Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans. J. Immunol. 162: 3088.
7. Penna, A., F. V. Chisari, A. Bertoletti, G. Missale, P. Fowler, T. Giuberti, F. Fiaccadori, and C. Ferrari. 1991. Cytotoxic T lymphocytes recognize an HLA-A2-restricted epitope within the hepatitis B virus nucleocapsid antigen. J. Exp. Med. 174:1565.
8. Tanaka, Y., A. Takahashi, K. Watanabe, K. Takayama, T. Yahata, S. Habu, and T. Nishimura. 1996. A pivotal role of IL-12 in Th1-dependent mouse liver injury. Int. Immunol. 8:569.
9. Tiegs, G., J. Hentschel, and A. Wendel. 1992. A T cell-dependent experimental liver injury in mice inducible by concanavalin A. J. Clin. Invest. 90:196.
10. Kusters, S., F. Gantner, G. Kunstle, and G. Tiegs. 1996. Interferon γ plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology 111:462.
11. Tanaka, Y., A. Takahashi, K. Kobayashi, I. Arai, S. Higuchi, S. Otomo, K. Watanabe, S. Habu, and T. Nishimura. 1995. Establishment of a T cell-dependent nude mouse liver injury model induced by Propionibacterium acnes and LPS. J. Immunol. Methods 182:21.
12. Nishimura, T., and A. Ohta. 1999. A critical role for antigen-specific Th1 cells in acute liver injury in mice. J. Immunol. 162:6503.
13. Chisari, F. V., and C. Ferrari. 1995. Hepatitis B virus immunopathogenesis. Annu. Rev. Immunol. 13:29.
14. Ando, K., T. Moriyama, L. G. Guidotti, S. Wirth, R. D. Schreiber, H. J. Schlicht, S.-N. Huang, and F. V. Chisari. 1993. Mechanisms of class I restricted immunopathology: a transgenic mouse model of fulminant hepatitis. J. Exp. Med. 178: 1541.
15. Nakamoto, Y., L. G. Guidotti, V. Pasquetto, R. D. Schreiber, and F. V. Chisari. 1997. Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice. J. Immunol. 158:5692.
16. Nakamoto, Y., L. G. Guidotti, C. V. Kuhlen, P. Fowler, and F. V. Chisari. 1998. Immune pathogenesis of hepatocellular carcinoma. J. Exp. Med. 188:341.
17. Franco, A., L. G. Guidotti, M. V. Hobbs, V. Pasquetlo, and F. V. Chisari. 1997. Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. J. Immunol. 159:2001.
18. Tsuji, H., N. Mukaide, A. Harada, S. Kaneko, E. Matsushita, Y. Nakanuma, H. Tsutsui, H. Okamura, K. Nakanishi, Y. Tagawa, et al. 1999. Alleviation of lipopolysaccharide-induced acute livet injury in Propionibacterium acnes-primed IFN-γ-deficient mice by a concomitant reduction of TNF-α. IL-12, and IL-18 production. J. Immunol. 162:1049.
19. Yoneyama, H., A. Harada, T. Imai, M. Baba, O. Yoshie, Y. Zhang, H. Higashi, M. Murai, H. Asakura, and K. Matsushima. 1998. Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J. Clin. Invest. 102:1933.
20. De Meyer, S., Z. J. Gong, W. Suwandhi, J. van Pelt, A. Soumillion, and S. H. Yap. 1997. Organ and species specificity of hepatitis B virus (HBV) infection: a review of literature with a special reference to preferential attachment of HBV to human hepatocytes. J. Viral Hepatitis 4:145.
21. Mehdi, H., M. J. Kaplan, F. Y. Anlar, X. Yang, R. Bayer, K. Sutherland, and M. E. Peeples. 1994. Hepatitis B virus surface antigen binds to apolipoprotein H. J. Virol. 68:2415.
22. Neurath, A. R., and N. Strick. 1994. The putative cell receptors for hepatitis B virus (HBV), annexin V, and apolipoprotein H, bind to lipid components of HBV. Virology 204:475.
23. Hertogs, K., W. P. Leenders, E. Depla, W. C. De Bruin, L. Meheus, J. Raymackers, H. Moshage, and S. H. Yap. 1993. Endonexin II, present on human liver plasma membranes, is a specific binding protein of small hepatitis B virus (HBV) envelope protein. Virology 197:549.
24. Gong, Z. J., S. De Meyer, J. van Pelt, K. Hertogs, E. Depla, A. Soumillion, J. Fevery, and S. H. Yap. 1999. Transfection of a rat hepatoma cell line with a construct expressing human liver annexin V confers susceptibility to hepatitis B virus infection. Hepatology 29:576.
25. Mizuhara, H., M. Kuno, N. Seki, W.-G. Yu, M. Yamaoka, M. Yamashita, T. Ogawa, K. Kaneda, T. Fujii, H. Senoh, and H. Fujiwara. 1998. Strain difference in the induction of T-cell activation-associated, interferon γ-dependent hepatic injury in mice. Hepatology 27:513.
26. Chatelain, R., K. Varkila, and R. L. Coffman. 1992. IL-4 induces a Th2 response in Leishmania major-infected mice. J. Immunol. 148:1182.
27. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
28. Shankar, A. H., and R. G. Titus. 1995. T cell and non-T cell compartments can independently determine resistance to Leishmania major. J. Exp. Med. 181:845.
29. - T cells in non-MHC gene-controlled predisposition toward skewing into T helper type-2 immunity in BALB/c mice. J. Immunol. 158:5698.
30. Hung, K., R. Hayashi, A. Lafond-Walker, C. Lowenstein, D. Pardoll, and H. Levitsky. 1998. The central role of CD4(+) T cells in the antitumor immune response. J. Exp. Med. 188:2357.
31. Nishimura, T., K. Iwakabe, M. Sekimoto, Y. Ohmi, T. Yahata, M. Nakui, T. Sato, S. Habu, H. Tashiro, M. Sato, and A. Ohta. 1999. A distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo. J. Exp. Med. 190:617.
32. + T cells for Concanavalin A-induced hepatic injury in mice. J. Immunol. 159:1537.
33. Nagakawa, J., I. Hishinuma, K. Hirota, K. Miyamoto, T. Yamanaka, K. Tsukida, K. Katayama, and I. Yamatsu. 1990. Involvement of tumor necrosis factor-α in the pathogenesis of activated-macrophage-mediated hepatitis in mice. Gastroenterology 99:758.
34. Gantner, F., M. Leist, A. W. Lohse, P. G. Germann, and G. Tiegs. 1995. Concanavalin A-induced T cell-mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology 21:190.
35. -/- mice: role for IFN-γ in activating apoptosis of hepatocytes. J. Immunol. 159:1418.
36. Majano, P. L., C. Garcia-Monzon, M. Lopez-Cabrera, E. Lara-Pezzi, E. Fernandez-Ruiz, C. Garcia-Iglesias, M. J. Borque, and R. Moreno-Otero, 1998. Inducible nitric oxide synthase expression in chronic viral hepatitis: evidence for a virus-induced gene up-regulation. J. Clin. Invest. 101:1343.
37. Morikawa, A., Y. Kato, T. Sugiyama, N. Koide, D. Chakravortty, T. Yoshida, and T. Yokochi, 1999. Role of nitric oxide in lipopolysaccharide-induced hepatic injury in D-galactosamine-sensitized mice as an experimental endotoxic shock model. Infect. Immun. 67:1018.
38. Schiller, J. H., G. Bittner, B. Storer, and J. K. Willson, 1987. Synergistic anti-tumor effects of tumor necrosis factor and γ-interferon on human colon carcinoma cell lines. Cancer Res. 47:2809.
39. Campbell, I. L., A. Iscaro, and L. C. Harrison. 1988, IFN-γ and tumor necrosis factor-α: cytotoxicity to murine islets of Langerhans. J. Immunol 141:2325.