Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 10, 1999, Pages 1459-1462

  Sum, Phaik Eng ^a   Petersen, Peter ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 (N,N DIMETHYLGLYCYLAMIDO) 6 DEMETHYL 6 DEOXYTETRACYCLINE; 9 N,N DIMETHYLGLYCYLAMIDOMINOCYCLINE; GLYCYLCYCLINE DERIVATIVE; TETRACYCLINE DERIVATIVE; TIGECYCLINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; MINOCYCLINE; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRACYCLINES;

EID: 0033577725     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00216-4     Document Type: Article

References (8)

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5. Testa, R. T.; Petersen, P. J.; Jacobus, N. V.; Sum, P.-E.; Lee, V. J.; Tally, F.P. Antimicrob. Agents Chemother. 1993, 37, 2270.
6. For a recent review of tetracycline, see: Sum, P.-E.; Sum, F.-W; Projan, S. J. Curr. Pharmaceut. Design 1998, 4, 119.
7. Petisi, J.; Spencer, J. L.; Hlavka, J. J.; Boothe, J. H. J. Med. Chem. 1962, 5, 538.
8. Petersen, P. J.; Jacobus, N. V.; Weiss, W. J.; Sum, P.-E.; Testa, R. T. Antimicrob. Agents Chemother. 1999, 43, 738.