Bactericidal activity of a single-dose combination of ofloxacin plus minocycline, with or without rifampin, against Mycobacterium leprae in mice and in lepromatous patients

Antimicrobial Agents and Chemotherapy

Volumn 42, Issue 5, 1998, Pages 1115-1120

  Ji, Baohong ^a   Sow, Samba ^b   Perani, Evelyne ^a   Lienhardt, Christian ^b   Diderot, Vimala ^a   Grosset, Jacques ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b Institut Marchoux Mali   (Mali)

Author keywords

[No Author keywords available]

Indexed keywords

MINOCYCLINE; OFLOXACIN; RIFAMPICIN;

ABDOMINAL PAIN; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERICIDAL ACTIVITY; CLINICAL ARTICLE; CLINICAL TRIAL; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENTIATION; DRUG TOLERABILITY; DRUG TOLERANCE; FEMALE; FOOT PAD; HUMAN; LEPROSY; MALE; MOUSE; MYCOBACTERIUM LEPRAE; NAUSEA; NONHUMAN; PRIORITY JOURNAL;

EID: 0031959013     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/aac.42.5.1115     Document Type: Article

References (29)

1. Chan, G. P., B. Y. Garcia-Ignacio, V. E. Chavez, J. B. Livelo, C. L. Jimenez, M. L. R. Parrilla, and S. G. Franzblau. 1994. Clinical trial of clarithromycin for lepromatous leprosy. Antimicrob. Agents Chemother. 38:515-517.
2. Colston, M. J., G. R. F. Hilson, and D. K. Bannerjee. 1978. The "proportional bactericidal test," a method for assessing bactericidal activity of drugs against Mycobacterium leprae in mice. Lepr. Rev. 49:7-15.
3. Ellard, G. A., V. K. Pannikar, K. Jesudasan, and M. Christian. 1988. Clofazimine and dapsone compliance in leprosy. Lepr. Rev. 59:205-223.
4. Fajardo, T. T., L. G. Villahermosa, E. C. dela Cruz, R. M. Abalos, S. G. Franzblau, and G. P. Walsh. 1995. Minocycline in lepromatous leprosy. Int. J. Lepr. 63:8-17.
5. Franzblau, S. G., and R. C. Hastings. 1988. In vitro and in vivo activities of macrolides against Mycobacterium leprae. Antimicrob. Agents Chemother. 32:1758-1762.
6. Franzblau, S. G., and K. E. White. 1990. Comparative in vitro activities of 20 fluoroquinolones against Mycobacterium leprae. Antimicrob. Agents Chemother. 34:229-231.
7. Franzblau, S. G., G. P. Chan, B. G. Garcia-Ignacio, V. E. Chavez, J. B. Livelo, C. L. Jiminez, M. L. R. Parrilla, R. F. Calvo, D. L. Williams, and T. P. Gillis. 1994. Clinical trial of fusidic acid for lepromatous leprosy. Antimicrob. Agents Chemother. 38:1651-1654.
8. Gelber, R. H. 1987. Activity of minocycline in Mycobacterium leprae-infected mice. J. Infect. Dis. 156:236-239.
9. Gelber, R. H., K. Fukuda, S. Byrd, L. P. Murray, P. Siu, M. Tsang, and T. H. Rea. 1992. A clinical trial of minocycline in lepromatous leprosy. Br. Med. J. 304:31-32.
10. Gelber, R. H., L. P. Murray, P. Siu, M. Tsang, and T. H. Rea. 1994. Efficacy of minocycline in single dose and at 100 mg twice daily for lepromatous leprosy. Int. J. Lepr. 62:568-573.
11. Gelber, R. H. 1995. Successful treatment of a lepromatous patient with clarithromycin. Int. J. Lepr. 63:113-115.
12. Grosset, J. H., C. C. Guelpa-Lauras, E. G. Perani, and C. Beoletto. 1988. Activity of ofloxacin against Mycobacterium leprae in the mouse. Int. J. Lepr. 56:259-264.
13. Grosset, J. H., B. Ji, C. C. Guelpa-Lauras, E. G. Perani, and L. N'Deli. 1990. Clinical trial of pefloxacin and ofloxacin in the treatment of lepromatous leprosy. Int. J. Lepr. 58:281-295.
14. Ji, B., and J. H. Grosset. 1990. Recent advances in the chemotherapy of leprosy. Lepr. Rev. 61:313-329. (Editorial.)
15. Ji, B., E. G. Perani, and J. H. Grosset. 1991. Effectiveness of clarithromycin and minocycline alone and in combination against experimental Mycobacterium leprae infection in mice. Antimicrob. Agents Chemother. 35:579-581.
16. Ji, B., E. G. Perani, C. Petinon, and J. H. Grosset. 1992. Bactericidal activities of single or multiple doses of various combinations of new antileprosy drugs and/or rifampicin against Mycobacterium leprae in mice. Int. J. Lepr. 60:556-561.
17. Ji, B., P. Jamet, E. G. Perani, P. Bobin, and J. H. Grosset. 1993. Powerful bactericidal activities of clarithromycin and minocycline against Mycobacterium leprae in lepromatous leprosy. J. Infect. Dis. 168:188-190.
18. Ji, B., E. G. Perani, C. Petinom, L. N'Deli, and J. H. Grosset. 1994. Clinical trial of ofloxacin alone and in combination with dapsone plus clofazimine for treatment of lepromatous leprosy. Antimicrob. Agents Chemother. 38:662-667.
19. Ji, B., E. G. Perani, C. Petinom, and J. H. Grosset. 1996. Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice. Antimicrob. Agents Chemother. 40:393-399.
20. Ji, B., P. Jamet, E. G. Perani, S. Sow, C. Lienhardt, C. Petinon, and J. H. Grosset. 1996. Bactericidal activity of single dose of clarithromycin plus minocycline, with or without ofloxacin, against Mycobacterium leprae in patients. Antimicrob. Agents Chemother. 40:2137-2141.
21. Ji, B., P. Jamet, S. Sow, E. G. Perani, I. Traore, and J. H. Grosset. 1997. High relapse rate among lepromatous leprosy patients treated with rifampin plus ofloxacin daily for 4 weeks. Antimicrob. Agents Chemother. 41:1953-1956.
22. Levy, L., C. C. Shepard, and P. Fasal. 1976. The bactericidal effect of rifampicin on M. leprae in man: (a) single doses of 600, 900, and 1200 mg; and (b) daily doses of 300 mg. Int. J. Lepr. 44:183-187.
23. Shepard, C. C., and D. H. McRae. 1968. A method for counting acid-fast bacilli. Int. J. Lepr. 36:78-82.
24. Shepard, C. C., L. Levy, and P. Fasal. 1972. Rapid bactericidal effect of rifampin on Mycobacterium leprae. Am. J. Trop. Med. Hyg. 21:446-449.
25. Shepard, C. C., L. Levy, and P. Fasal. 1974. Further experience with the rapid bactericidal effect of rifampin on Mycobacterium leprae. Am. J. Trop. Med. Hyg. 23:1120-1124.
26. Shepard, C. C. 1982. Statistical analysis of results obtained by two methods for testing drug activity against Mycobacterium leprae. Int. J. Lepr. 50:96-101.
27. Single-Lesion Multicentre Trial Group. 1997. Efficacy of single dose multidrug therapy for the treatment of single-lesion paucibacillary leprosy. Indian J. Lepr. 69:121-129.
28. Truffot-Pernot, C., B. Ji, and J. H. Grosset. 1991. Activities of pefloxacin and ofloxacin against mycobacteria: in vitro and mouse experiments. Tubercle 72:57-64.
29. WHO Study Group. 1982. Chemotherapy of leprosy for control programmes. Technical Report Series no. 675. World Health Organization, Geneva, Switzerland.