Crystal structure of the Tet repressor in complex with a novel tetracycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxy-tetracycline

Journal of Molecular Biology

Volumn 285, Issue 2, 1999, Pages 455-461

  Orth, Peter ^a   Schnappinger, Dirk ^b   Sum, Phaik Eng ^c   Ellestad, George A ^c   Hillen, Wolfgang ^b   Saenger, Wolfram ^a   Hinrichs, Winfried ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c PFIZER INC   (United States)

Author keywords

Antibiotic resistance; Glycylcycline; Tet repressor; Tetracycline; X ray crystallography

Indexed keywords

9 (N,N DIMETHYLGLYCYLAMIDO) 6 DEMETHYL 6 DEOXYTETRACYCLINE; REPRESSOR PROTEIN; TETRACYCLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; POINT MUTATION; PRIORITY JOURNAL;

EID: 0033555296     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2290     Document Type: Article

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